electrical properties of nuerons Flashcards

1
Q

what is the basic unit for nervous system

A

nuerons … they generate electrical signals and communicate to other nuerons

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2
Q

neuron basic features

  • cell body
  • one side there is
A
  • that hosts nucleus and different organelles

- dentrites= receives signals from environment or other nuerons

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3
Q

neuron electrical signals

A

travel from dendrites, across axon

then signal is relayed at axon terminal to another neuron

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4
Q

what happens on axon terminal

A

info relayed chemically thru synpatic commiucation

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5
Q

function of neuron

A

transform electrical info into chemical info

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6
Q

main function of plasma membrane

A

act as barrier , distingushes intracellular components from the extra cellular space

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7
Q

structure of membrane

A

phospholipids, contains hydrophilic head which is polar (faces the cytosol and extracellular space)

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8
Q

phosolipid tails

A

hydrophobic
face each other
provide a very hydrophobic environment that is v impermeable to lots of molecules

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9
Q

what can pass the membrane

A
  • gases
  • very small uncharged molecules
  • very few small charged molecules
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10
Q

what can not pass the membrane

A

ions

large charged molecules

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11
Q

water passing through

A

water can pass the membrane if the driving force is very strong

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12
Q

types of transport across membrane

A
  1. diffusion ( only for gases) no requirement for engery
  2. facilitaed diffusion HIGH —-> LOW

active transport requires ATP. L—->H

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13
Q

facilitated diffusion applies to

A

molecules that are not permeable in the membrane tf they cant pass on their own

tf they need protein … channels or protein carriers

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14
Q

active transport

A

energy required to move a substance across a membrane against its concentration gradient

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15
Q

why does active transport need ATP

A

going from low conc to high conc

tf need to break energetic barrier of going against conc.

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16
Q

the electrochemical gradient is

A

combination of concentration and charge differences across the membrane

driving force for ion transport

17
Q

nueronal membrane charge

A

negatively charged on cytoplasmic side

positively charged on extracellular side

18
Q

membrane potential:
charge Q
current I

A
  • net imbalance of number of positively charged and negatively charged particles in a given place
  • flow of electrically charged particles , in body fluids these are ions eg Na+, K+ , Cl-
19
Q

membrane potential:

voltage V

A

measure of potential difference between two points . In these points , one of them is more positive than the other .

20
Q

in the context of nuerons and their membranes , electrical voltage represents the

A

electrical potential energy gradient.

since one side is + and other side is - , the electrical potential energy will drive charged particles to go from one side to another

21
Q

electrical potential (voltage)

A

difference in charged between inside v outside of cell

22
Q

why does interior of cell have relative negative net charge in comparison to outside of the cell

A

ionic composition of cytoplasm

23
Q

membrane potential:
electrical gradient
-influenced by
-ions

A

–overall electrical charge

-positive ions would flow to areas of negative charge

24
Q

membrane potential :
chemical gradient
-influenced by
-ions

A
  • individual conc. of a particular ion

- all ions move to areas of high conc. to low

25
the direction an ion will move depends on
overall net effect of chem and electrical gradients Permeability of membrane to ion (no channels = no movement even with strong gradient)
26
How is the gradient maintained
Na is more conc. on outside cell and K more conc on inside. when channels open, Na will enter cell and K will leave cell this is promoted by the sodium potassium pump by maintaining ATP from the ATP molecule
27
Na+-K+ Pump is a
P-type transport ATPase
28
how much energy does Na K pump use
1/3 of cells energy
29
what changes the shape and structure of the pump
Phosphorylation exposing ion binding sites on to extracellular and cytosolic faces of the membrane
30
Equilibrium potential
electrical potential difference that exactly counterbalances diffusion due to conc difference
31
Ion Channels present in states ion selectivity:
all cells , most sophisticated on electrically excitable cells conducting and non-conducting states eg open and close ... transition between states is 'gating' Na+,K+,Ca2+,Cl- or cations.
32
Na+-K+ ATPase exchanger | pt1
1. binding cytoplasmic Na+ stimulates ATP (autophosphorylation) 2. Phosphorylation causes conformational change 3. Na+ is released outside and by doing that the pump exposes K+ binding sites
33
Na+-K+ ATPase exchanger | pt2
4. binding the K+ triggers the release of phosphate 5. release of phosphate restores the original conformation 6. K+ is released and Na+ binding sites are exposed again in cytoplasm