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pharmacology > drugs for mood disorders > Flashcards

drugs for mood disorders Flashcards

1
Q

3 classes of NT

A

small molecule, neuro peptides, NT gases

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2
Q

small molecule NT

A

dopamine

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3
Q

neuropeptide

A

substance p

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4
Q

NT gases

A

NO

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5
Q

NT important in memory

A

acetylcholine

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6
Q

monoamines

A

dopamine, NE, E, serotonin

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7
Q

dopamine, serotonin, NE, E are what

A

monoamides

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8
Q

what system maintains emotional tone

A

noreadrenegric system

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9
Q

what NT is in the noreadrenergic system

A

NE

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10
Q

serotinergic system maintains what

A

maintains sleep wake cycle, emotional tone, and sensory perceptions

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11
Q

maintains sleep wake cycle, emotional tone, and sensory perceptions

A

serotonergic system

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12
Q

noradrenergic and serotonin system are metablozied by what

A

MAO enzyme

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13
Q

§ Lack of energy
§ Sleep disturbances
§ Abnormal eating patterns
§ Feelings of despair, guilt or hopelessness
§ Most common mental health disorder of older adults
§ Encompasses physical, emotional, cognitive and social factors
are symtpoms of what

A

major depressive disorder

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14
Q

biological cause and family history can be linked to what mood disorder

A

major depressive

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15
Q

short lasting, often reactive as a result of a circumstance is what

A

situational depression

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16
Q

what depression presents 2 weeks to 6 months after childbirth

A

postpartum

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17
Q

what disorder is associated with dark winter months and lower levels of natural light

A

seasonal affective disorder

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18
Q

antidepressant drugs

A

are used to treat depression by enhancing mood

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19
Q

what is effective in treating both the psychological and physical signs of pain

A

antidepressants

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20
Q

how do antidepressants exert their effects

A

through actions on dopamine, serotonin, and NE

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21
Q

what block the enzymatic breakdown of NE and slow the reuptake of serotonin and norepinephrine

A

antidepressants

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22
Q

SSRIS

A

inhibit serotonin reuptake into the presynaptic neuron

23
Q

what have no affinity for histamine, alpha adrenergic or muscarinic receptors - shows a narrow affinity

A

ssris

24
Q

what is the prefered drug class for depression

A

ssris

25
Q

why should the discontinuation of SSRIS be gradual?

A

to avoid withdrawl affects such as nausea, dizziness, anxiety, tremor, palpitations

26
Q

what is serotonin syndrome

A

this is associated with extreme increases in serotonin levels

27
Q

how does serotonin syndrome happen

A

caused by the co-adminsitration of drugs that cause an increase in serotonin

28
Q

SSRIS and MAOS can cause what

A

drug drug can cause serotonin syndrome

29
Q

SSRIS and TCAs

A

drug drug can cause SES

30
Q

SSRIS and lithium

A

can cause ses

31
Q

ssris and st. johns wart.

A

can cause ses

32
Q

MDMA and SSRIS

A

can cause ses

33
Q

SSRIS and fentanyl

A

can cause ses

34
Q

SNRIS

A

inhibit the reuptake of serotonin and NE to elevate mood

35
Q

what inhibit the reuptake of serotonin and NE to enhance mood

A

SNRIS

36
Q

what may increase the risk of post partum hemorrhage

A

SNRIS

37
Q

NDRIS

A

inhibit dopamine and epinephrine reuptake

38
Q

what drug is contraindicated in those with seizure disorders

A

NDRIS

39
Q

tricyclic antidepressants

A

inhibit NE, 5-HT and DA reuptake into the presynaptic neuron, increasing NE, 5HT and DA levels in the synapse

40
Q

inhibit NE, 5-HT and DA reuptake into the presynaptic neuron, increasing NE, 5HT and DA levels in the synapse

A

tricyclic antidepressants

41
Q

what antidepressant shows delay in efficacy, and has an affinity for histaminergic, muscarinic and a1 adrenergic receptors

A

tricyclic antidepressants

42
Q

monoamine oxidase inhibitor drugs (MAO(S)

A

deaminates DA, NE, and 5HT, inhibits MAO enzyme increasing monoamine levels

43
Q

what deaminates DA, NE, and 5HT, inhibits MAO enzyme increasing monoamine levels

A

monoamine enzyme inhibitors

44
Q

adverse effects of MAOIS

A

orthostatic hypotension, headache, insomnia, and diarrhea

45
Q

what is a hypertensive crisis assocated with

A

serotonin syndrome and elevated levels of tyramine

46
Q

what is associated with SES and elevated levels of tyramine

A

hypertensive crisis

47
Q

mood stabilizer - lithium

A

inhibits the synthesis of POP, decreasing the generation of IP3 and DAG

48
Q

what inhibits the synthesis of POP, decreasing the generation of IP3 and DAG

A

lithium

49
Q

what can be co-administered with litium

A

antidepressants and benzo

50
Q

lithium toxicity can cause what

A

muscle weakness, lack of coordination, vomiting, diarrhea, tremor, twitching, lethargy, mental confusion, polyuria

51
Q

muscle weakness, lack of coordination, vomiting, diarrhea, tremor, twitching, lethargy, mental confusion, polyuria are all symptoms of what

A

lithium toxicity

52
Q

why must someone only take lithium at night

A

to protect the kidneys

53
Q

antiseizure drugs adverse effects

A

dizziness, drowsiness, headache, nausea, blurred vision, sedation

pharmacology (26 decks)

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