drugs for mood disorders Flashcards
3 classes of NT
small molecule, neuro peptides, NT gases
small molecule NT
dopamine
neuropeptide
substance p
NT gases
NO
NT important in memory
acetylcholine
monoamines
dopamine, NE, E, serotonin
dopamine, serotonin, NE, E are what
monoamides
what system maintains emotional tone
noreadrenegric system
what NT is in the noreadrenergic system
NE
serotinergic system maintains what
maintains sleep wake cycle, emotional tone, and sensory perceptions
maintains sleep wake cycle, emotional tone, and sensory perceptions
serotonergic system
noradrenergic and serotonin system are metablozied by what
MAO enzyme
§ Lack of energy
§ Sleep disturbances
§ Abnormal eating patterns
§ Feelings of despair, guilt or hopelessness
§ Most common mental health disorder of older adults
§ Encompasses physical, emotional, cognitive and social factors
are symtpoms of what
major depressive disorder
biological cause and family history can be linked to what mood disorder
major depressive
short lasting, often reactive as a result of a circumstance is what
situational depression
what depression presents 2 weeks to 6 months after childbirth
postpartum
what disorder is associated with dark winter months and lower levels of natural light
seasonal affective disorder
antidepressant drugs
are used to treat depression by enhancing mood
what is effective in treating both the psychological and physical signs of pain
antidepressants
how do antidepressants exert their effects
through actions on dopamine, serotonin, and NE
what block the enzymatic breakdown of NE and slow the reuptake of serotonin and norepinephrine
antidepressants
SSRIS
inhibit serotonin reuptake into the presynaptic neuron
what have no affinity for histamine, alpha adrenergic or muscarinic receptors - shows a narrow affinity
ssris
what is the prefered drug class for depression
ssris
why should the discontinuation of SSRIS be gradual?
to avoid withdrawl affects such as nausea, dizziness, anxiety, tremor, palpitations
what is serotonin syndrome
this is associated with extreme increases in serotonin levels
how does serotonin syndrome happen
caused by the co-adminsitration of drugs that cause an increase in serotonin
SSRIS and MAOS can cause what
drug drug can cause serotonin syndrome
SSRIS and TCAs
drug drug can cause SES
SSRIS and lithium
can cause ses
ssris and st. johns wart.
can cause ses
MDMA and SSRIS
can cause ses
SSRIS and fentanyl
can cause ses
SNRIS
inhibit the reuptake of serotonin and NE to elevate mood
what inhibit the reuptake of serotonin and NE to enhance mood
SNRIS
what may increase the risk of post partum hemorrhage
SNRIS
NDRIS
inhibit dopamine and epinephrine reuptake
what drug is contraindicated in those with seizure disorders
NDRIS
tricyclic antidepressants
inhibit NE, 5-HT and DA reuptake into the presynaptic neuron, increasing NE, 5HT and DA levels in the synapse
inhibit NE, 5-HT and DA reuptake into the presynaptic neuron, increasing NE, 5HT and DA levels in the synapse
tricyclic antidepressants
what antidepressant shows delay in efficacy, and has an affinity for histaminergic, muscarinic and a1 adrenergic receptors
tricyclic antidepressants
monoamine oxidase inhibitor drugs (MAO(S)
deaminates DA, NE, and 5HT, inhibits MAO enzyme increasing monoamine levels
what deaminates DA, NE, and 5HT, inhibits MAO enzyme increasing monoamine levels
monoamine enzyme inhibitors
adverse effects of MAOIS
orthostatic hypotension, headache, insomnia, and diarrhea
what is a hypertensive crisis assocated with
serotonin syndrome and elevated levels of tyramine
what is associated with SES and elevated levels of tyramine
hypertensive crisis
mood stabilizer - lithium
inhibits the synthesis of POP, decreasing the generation of IP3 and DAG
what inhibits the synthesis of POP, decreasing the generation of IP3 and DAG
lithium
what can be co-administered with litium
antidepressants and benzo
lithium toxicity can cause what
muscle weakness, lack of coordination, vomiting, diarrhea, tremor, twitching, lethargy, mental confusion, polyuria
muscle weakness, lack of coordination, vomiting, diarrhea, tremor, twitching, lethargy, mental confusion, polyuria are all symptoms of what
lithium toxicity
why must someone only take lithium at night
to protect the kidneys
antiseizure drugs adverse effects
dizziness, drowsiness, headache, nausea, blurred vision, sedation
