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pharmacology > drugs for female reproductive system > Flashcards

drugs for female reproductive system Flashcards

1
Q

what are water soluble binding hormones

A

they bind to cell surface receptors leading in the manufacturing of second messangers

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2
Q

what g proteins do water soluble endocrine hormones active

A

NE, E, oxytocin

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3
Q

what water soluble hormones bind to extracellular receptors

A

insulin and GH

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4
Q

what are lipid soluble endocrine hormones

A

estorgen, testosotrone, progesterone, thyroid hormone, cortisol, aldosterone

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5
Q

what do lipid soluble endocrine hormones act as?

A

transcription factor

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6
Q

what hormones move through the blood stream bound to a transport protien

A

lipid soluble hormones

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7
Q

where is gonadotropin produced

A

hypothalamus

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8
Q

what hormones are produced in the anterior pit

A

luteinizing hormone and follicle stimulating hormone

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9
Q

what steroids increase sex drive, libido, and secondary sexual charactertistics

A

sex steroids such as prigesterone, estrogens, and androgens

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10
Q

hormonal changes during ovarian and uterine cycles; what does the hypothalamus release and what us produced

A

secrrets GnRH and LH and FSH from ant pit

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11
Q

what does the production of LH and FSH do?

A

stimulate follicle maturation

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12
Q

if there is no follicle maturation, what happens

A

there is no ovulation

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13
Q

what does increased estrogen and progesterone production promote?

A

promote endometrial vascularization and thickening

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14
Q

the release of what stimulates ovulation

A

high levels of estrogens

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15
Q

what does the release of high levels of estrogen stimulate

A

surge in LH, FSH

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16
Q

what happens when there is no fertilization

A

GnRH, LH, FSH levels fall, estrogen and progesterone secretion is inhibited and menstruation begins

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17
Q

what is the most potent estrogen and is the major ovarian estrogen

A

estradiol

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18
Q

estradiol

A

arises form the action of aromatoase on testostorone

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19
Q

what is the predominant form of estrogen in menopause

A

estrone

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20
Q

what estrogen is primary circulating in fatty tissues during menopause

A

estrone

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21
Q

when estrogen is stored in fatty tissues what is it stored as?

A

estrone

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22
Q

what is the primary circulating form of estrogen during pregnancy

A

estriol

23
Q

what is the role of estrogens

A
  1. growth and maturation of female reproductive organs, endometrium proliferation and thickening of the vaginal mucosa
  2. female pattern fat depsition
  3. increased bone deposition
  4. increased vascularity of the skin
  5. decreased LDL and increased HDL
  6. increased coagulation
  7. production of thin, clear, watery, and elastic cervical mucus
24
Q

role of progestins

A

these work to thicken mucous, preventing sperm entry

25
Q

what can help the body protect itself from getting pregnant while pregnant

A

progestins

26
Q

what is the most active endogenous progestin

A

progesterone

27
Q

what is a combination oral contraceptive

A

combination of synthetic forms of estrogen and progestin

28
Q

how do combination contraceptives inhibit ovulation

A

synthetic hormones exploit negative feedback loop, preventing follicle maturation and ovulation

29
Q

low dose of synthetic estrogens and progestins can inhibit what levels

A

FSH and LH

30
Q

synthetic progestins do what to the endometrieum

A

make it think and inactive

31
Q

what produces a thick cervical mucus to inhibit sperm migration

A

synthetic proogestins

32
Q

benefits of combination contraceptives

A

reduced PMS symptoms, reduction in the risk of certain cancers, decreased risk of ovarian cysts and endometriousis, improvements in bone mineral density

33
Q

what might happen if someone is given too much progestin

A

increased appetite, weight gain, fatigue, depression, acne

34
Q

what might happen if the levels of progestin are too low

A

menstrual irregularities

35
Q

what do estorgens increase the risk of

A

thromboembolic disorders

36
Q

when should you be cautious of prescribing combination contraceptives?

A

liver issues, migraines with aura, smoking, impaired cardiac function, history of stroke, MI, CAD, thromboembolic disorders

37
Q

what is the function of progestin only contraceptives with the endometrium and mucous

A

creates a thick and viscous mucus, endometrium is kept in atrophic state

38
Q

forms of progestin only contraceptives

A

minipill, subdermal implants, depo

39
Q

what are some adverse affects of progestin only contraceptives

A

greater risk of menstrual irregularities, breakthrough, increased risk of ovarian cysts and breast cancers, increased appetite and fatigue, weight gain

40
Q

greater risk of menstrual irregularities, breakthrough, increased risk of ovarian cysts and breast cancers, increased appetite and fatigue, weight gain are all adverse affects of what

A

progestin only

41
Q

emergency contraception - plan B

A

used to prevent unplanned pregnancy related to unprotected sexual intercourse or contraceptive failure

42
Q

side affects of plan b

A

nausea, vomiting, dizziness, headache, fatigue, diarrhea, abdominal pain

43
Q

what should be administered after taking plan b, due to potential side effects?

A

antiemetic drug - gravol

44
Q

abortifacients

A

used to terminate an unwanted pregnancy up to a gestational age of 63 days

45
Q

what is mifepristone

A

this is a progesterone modulator, blocks the effects of progesterone on the endometrium and myometrium

46
Q

what is misoprostol

A

prostagladin, induces contractions of the uterine myometrium and cervical dialation

47
Q

what prostagladin, induces contractions of the uterine myometrium and cervical dialation

A

misoprostol

48
Q

what are side effects of abortificaients

A

pain, cramping, diarrhea, nausea, emesis, fever, chills, dizziness, weakness

49
Q

what is hormone replacement therapy used to treat?

A

primary ovarian failure and symptoms of menopause

50
Q

bad menopause symptoms include;

A

insomnia, hot flashes, vaginal atrophy, mood disturbances, irritability, osteoporosis

51
Q

duavivie - what is it

A

hormone replacement therapy

52
Q

what is duavive made up of?

A

estrogen and bazedoxifene

53
Q

what do bazedoxifenes do?

A

they antagonize the effect of estrogen on the uterus, reducing the risk of uterine cancer, agonist activity on the bone

54
Q

what demonstrates agonist activity on the bone?

A

bazedoxifene

pharmacology (26 decks)

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