cellular receptors and drug action Flashcards
if a receptor is inside the cell, what kind of endogenous ligand is it going to have
it means that the endogenous liagnd is fat soluble, this is because the fat soluble can pass the inside of the cell
intracellular receptor
inside the cell, the endogenous ligand is very small and fat soluble
intracellular receptors directly effect what
our DNA
spanning enzymes
insulin - the receptor is located inside the membrane
receptor located on a ion channel
binds to receptor, ion channel opens, causing an influx of molecules
g-protien coupled receptors
they stimulate effectors to produce intracellular changes
what g-protiens subgroups exist
gs, gi, gq
what receptors interact with g protiens
light, odorants, hormones, neurotransmitters, and prostaglandins
what effectors are associated with the cAMP signal transduction pathway
adenylyl cyclase
what are gs and gi always affecting
adenylyl cyclase
what happens when adenylyl cyclase is activated
it turns ATP into AMP then CAMP
phospholipase C
only associated with gq
phospholipase C is associated with what signal transduction pathway
phsophatidylinositol
PIP yields how many messangers?
2 - IP3 and DAG
what is IP3 and DAG - what changes do they lead to
these are secondary messangers in the cell that lead to physiological changes
