drugs for inflammation, fever, allergies Flashcards
acute inflammation
associated with physical injury, chemical damage, infection, antigens
how long does acute inflammation typically last
7-10 days
chronic inflammation may occur when
may occur if the body is not able to contain or neutralize the agent causing the initial inflammation
may occur if the body is not able to contain or neutralize the agent causing the initial inflammation
this is chronic inflammation
what inflammation leads to tissue damage
chronic
what are the chemical mediators of inflammation
bradykinins, complement, histamine, leukotrienes, prostaglandins
bradykinins, complement, histamine, leukotrienes, prostaglandins
these are the chemical mediators of inflammation
when tissue is damaged, what is produced
arachidonic acids
what is the arachidonic acid pathway
tissue damaged –> AA produced
cyclooxyegnase converts AA into prostagladins
prostaglandins enhance vasodialation
TXA - platelet aggregation
lipoxyegnase converts AA into leukotrienes
tissue damaged –> AA produced
cyclooxyegnase converts AA into prostagladins
prostaglandins enhance vasodialation
TXA - platelet aggregation
lipoxyegnase converts AA into leukotrienes
AA pathway
what is the goal of anti-inflammatory drugs
to prevent or decrease the intensity response and reduce fever if present
what are the two drug classes best fro preventing fever
NSAIDS
gluccorticoids
what are NSAIDS used for
mild-moderate pain, inflammation and fever
why would one be prescribed NSAIDS
if they experiencing mild-moderate pain, inflammation and fever
glucocorticoids are used for what kind of inflammation
used for severe/disabling inflammation
NSAIDS non-selective
work to reduce pain and inflammation by inhibiting enzymatic activity of COX 1 and 2
what works to reduce pain and inflammation by inhibiting the activity of COX 1 and 2
non-selective nsaids
nsaids inhibit what enzymes
inhibit cox 1 and 2
what do NSAIDS prevent (4)
inflammation and fever
inhibits the formation of gastric mucosa
increases gastric acid secretion
inhibits platelet aggregation
inflammation and fever
inhibits the formation of gastric mucosa
increases gastric acid secretion
inhibits platelet aggregation
nsaids
what is the second leading cause of peptic ulcers
NSAIDS - since they inhibit the pain of inflammation, sometimes they can stop the pain of peptic ulcers as well so they go unnoticed
how does glucocorticoid therapy work (3)
works to;
inhibit the release of histamines
block the immune response
block the activity of phospholipase a2 and cox2 enzymes
works to;
inhibit the release of histamines
block the immune response
block the activity of phospholipase a2 and cox2 enzymes
glucocorticoid therapy
adverse effects of glucocorticoid therapy
adrenal insufficiency, hyperglycemia, mood changes, osteoporosis, immunosupression
antipyretics
good for fever
reyes syndrome
associated with previous viral illnesses causing brain inflammation, faaty depsoits in liver
antihistamines
block the action of histamine at the h1 receptor for treatment of allergic reactions
anaphylaxis is associated with what
associated with a hyperimmune and hyper-inflammatory response to an antigen
what is associated with a hyper-immune and hyper-inflammatory response to an antigen
anaphylaxis
when does the body respond in minutes to the antigen, releasing massive amounts of histamine and other chemical modulators of inflammation
anaphylaxis
adrenergic agonist
Epinephrine
epinerphine effects on alpha and beta 1 and 2
a1 - increased bp
beta 2 - bronchiodialation
b1- increased CO
