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pharmacology > drugs for inflammation, fever, allergies > Flashcards

drugs for inflammation, fever, allergies Flashcards

1
Q

acute inflammation

A

associated with physical injury, chemical damage, infection, antigens

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2
Q

how long does acute inflammation typically last

A

7-10 days

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3
Q

chronic inflammation may occur when

A

may occur if the body is not able to contain or neutralize the agent causing the initial inflammation

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4
Q

may occur if the body is not able to contain or neutralize the agent causing the initial inflammation

A

this is chronic inflammation

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5
Q

what inflammation leads to tissue damage

A

chronic

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6
Q

what are the chemical mediators of inflammation

A

bradykinins, complement, histamine, leukotrienes, prostaglandins

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7
Q

bradykinins, complement, histamine, leukotrienes, prostaglandins

A

these are the chemical mediators of inflammation

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8
Q

when tissue is damaged, what is produced

A

arachidonic acids

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9
Q

what is the arachidonic acid pathway

A

tissue damaged –> AA produced
cyclooxyegnase converts AA into prostagladins
prostaglandins enhance vasodialation
TXA - platelet aggregation
lipoxyegnase converts AA into leukotrienes

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10
Q

tissue damaged –> AA produced
cyclooxyegnase converts AA into prostagladins
prostaglandins enhance vasodialation
TXA - platelet aggregation
lipoxyegnase converts AA into leukotrienes

A

AA pathway

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11
Q

what is the goal of anti-inflammatory drugs

A

to prevent or decrease the intensity response and reduce fever if present

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12
Q

what are the two drug classes best fro preventing fever

A

NSAIDS

gluccorticoids

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13
Q

what are NSAIDS used for

A

mild-moderate pain, inflammation and fever

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14
Q

why would one be prescribed NSAIDS

A

if they experiencing mild-moderate pain, inflammation and fever

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15
Q

glucocorticoids are used for what kind of inflammation

A

used for severe/disabling inflammation

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16
Q

NSAIDS non-selective

A

work to reduce pain and inflammation by inhibiting enzymatic activity of COX 1 and 2

17
Q

what works to reduce pain and inflammation by inhibiting the activity of COX 1 and 2

A

non-selective nsaids

18
Q

nsaids inhibit what enzymes

A

inhibit cox 1 and 2

19
Q

what do NSAIDS prevent (4)

A

inflammation and fever
inhibits the formation of gastric mucosa
increases gastric acid secretion
inhibits platelet aggregation

20
Q

inflammation and fever
inhibits the formation of gastric mucosa
increases gastric acid secretion
inhibits platelet aggregation

A

nsaids

21
Q

what is the second leading cause of peptic ulcers

A

NSAIDS - since they inhibit the pain of inflammation, sometimes they can stop the pain of peptic ulcers as well so they go unnoticed

22
Q

how does glucocorticoid therapy work (3)

A

works to;
inhibit the release of histamines
block the immune response
block the activity of phospholipase a2 and cox2 enzymes

23
Q

works to;
inhibit the release of histamines
block the immune response
block the activity of phospholipase a2 and cox2 enzymes

A

glucocorticoid therapy

24
Q

adverse effects of glucocorticoid therapy

A

adrenal insufficiency, hyperglycemia, mood changes, osteoporosis, immunosupression

25
Q

antipyretics

A

good for fever

26
Q

reyes syndrome

A

associated with previous viral illnesses causing brain inflammation, faaty depsoits in liver

27
Q

antihistamines

A

block the action of histamine at the h1 receptor for treatment of allergic reactions

28
Q

anaphylaxis is associated with what

A

associated with a hyperimmune and hyper-inflammatory response to an antigen

29
Q

what is associated with a hyper-immune and hyper-inflammatory response to an antigen

A

anaphylaxis

30
Q

when does the body respond in minutes to the antigen, releasing massive amounts of histamine and other chemical modulators of inflammation

A

anaphylaxis

31
Q

adrenergic agonist

A

Epinephrine

32
Q

epinerphine effects on alpha and beta 1 and 2

A

a1 - increased bp
beta 2 - bronchiodialation
b1- increased CO

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