drugs affecting cardiac rate and force

Question 1

ivabradine mechanism

Answer 1

blocks HCN channels

Question 2

ivabradine use

Answer 2

slow HR in angina, when patients cant take beta blocker

Question 3

catecholamines

Answer 3

B ADR agonist - inc force, rate, CO and O2 consumption

Question 4

Beta blocker mechanisms

Answer 4

dec CO - depress myocardial contractility and reduce the HR

Question 5

beta blocker -selective

Answer 5

atenolol, bisoprolol and metoprolol - for B1

Question 6

beta blocker non selective

Answer 6

propanolol

Question 7

alprenolol

Answer 7

non selective and partial agonist

Question 8

beta blocker clinical use

Answer 8

angina
heart failure
hypertension

Question 9

beta blockers - HF important!

Answer 9

not in acute!! as dec CO

only for mild and chronic heart failure

Question 10

clinical use of propranolol (non selective)

Answer 10

thyrotoxicosis

Question 11

beta blocker AE

Answer 11

bronchospasm - never asthma !!
bradycardia 
HF
fatigue 
cold peripheries 
hypoglycaemia

Question 12

atropine mechanisms

Answer 12

Causes multiple organ effects by blocking neuroeffector transmission in the parasympathetic division of the autonomic nervous system by competitive antagonism of muscarinic acetylcholine receptors.

Question 13

atropine use

Answer 13

bradycardia

anti cholinesterase poisoning

Question 14

alternative to atropine

Answer 14

glycopyrronium

Question 15

digoxin indirect effects are made use in

Answer 15

AF

Question 16

digoxin indirect effects

Answer 16

slows the HR
slows AV conductance
prolonges refractory period of AV node