cholesterol and lipid drugs

Question 1

statin AE

Answer 1

muscle ache
abdominal discomfort
inc transmainases
muscle inflammation (myositis)

Question 2

what do u add to statins if they aren’t achieving a sufficient response

Answer 2

ezetimbe

Question 3

fibrate action

Answer 3

agonists of PPAR - alpha to enhance the action of LPL

Question 4

fibrate AE

Answer 4

myositis

- unadvisable to give with statins as they cause this too

Question 5

what happens if u combine fibrate with statin or alcohol

Answer 5

muscle toxicity and renal failure

Question 6

bile acid sequestrant action

Answer 6

trap bile salts in intestine inc their excretion
more cholesterol converted to bile salts
inc HMG Co A reductase action

Question 7

colestryamine and colestipol administration

Answer 7

powder with liquid

Question 8

biel acid sequestrant AE

Answer 8

confined to gut - bloating, discomfort, diarrhoea and constipation

Question 9

who is ezetimbe contraindicated in

Answer 9

breast feeding females

Question 10

nicotinic acids action

Answer 10

inhibit VLPL synthesis and release