Drug rxns Flashcards by Rishi Sheth

coronary vasospasm

cocaine
sumatriptan
ergot alkaloids

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cutaneous flushing

vancomycin
adenosine
niacin
CCB

“VANC”

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dilated cardiomyopathy

doxorubicin (adriamycin)

daunorubicin

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torsades de pointes

class III (sotalol) and class IA (quinidine) antiarrhythmics

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agranulocytosis

clozapine
carbamazepine
cochicine
PTU
methimazole
dapsone

“Agranulocytosis Could Certainly Cause Pretty Major Damage”

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Aplastic anemia

chloramphenicol
benzene
NSAIDs
PTU
methimazole

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direct Coombs-positive hemolytic anemia

methyldopa

penicillin

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gray baby synd

chloramphenicol

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hemolysis in G6PD-deficient pts

isoniazid
sulfonamides
primaquine
aspirin
ibuprofen
nitrofuratoin

“hemolysis IS PAIN”

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megaloblastic anemia

phenytoin
methotrexate
sulfa drugs

“having a BLAST w/ PMS”

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thrombotic complications

OCPs (eg. estrogen)

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cough

ACE inhibitors

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pulmonary fibrosis

bleomycin
amiodarone
busulfan

“it’s hard to BLAB when you have pulm fibrosis”

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acute cholestatic hepatitis, jaundice

erythromycin

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focal to massive hepatic necrosis

halothane
amanita phalloides
valproic acid
acetominophen

“liver HAVAc”

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hepatitis

INH

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pseudomembranous colitis

clindamycin

ampicillin

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adrenocortical insuff

glucocorticoid withdrawal (HPA suppression)

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gynecomastia

spironolactone
digitalis
cimetidine
chronic alcohol use
estrogens
ketoconazole

“Some Drugs Create Awkward Knockers”

hot flashes

tamoxifen

clomiphene

hyperglycemia

niacin
tacrolimus
protease inhibitors
HCTZ
corticosteroids

hypothyroidism

lithium
amiodarone
sulfonamides

fat redistribution

glucocorticoids

protease inhibitors

gingival hyperplasia

phenytoin

verapamil

gout

furosemide thiazides niacin cyclosporine

myopathies

``` Fibrates Niacin Colchicine Hydroxychloroquine IFN-alpha Penicillamine Statins Glucocorticoids ``` "Fish N CHIPS Give you myopathies" statins + fibrates greatly increases risk

osteoporosis

corticosteroids | heparin

photosensitivity

Sulfonamides Amiodarone Tetracycline "SAT for a photo"

Rash (Stevens-Johnson synd)

``` Pencillin Ethosuxamide Carbamazepine Sulfa drugs Lamotrigine Allopurinol Phenytoin Phenobarbital ``` "bad rash after a PEC SLAPP" 3 main categories that cause it: penicillin, sulfa drugs, seizure drugs

SLE-like synd

Hydralazine INH Procainamide Phenytoin "it's not HIPP to have lupus"

Teeth (kids)

tetracyclines

tendonitis, tendon rupture, cartilage damage

fluoroquinolones

diabetes insipidus

Lithium | demeclocycline

Fanconi's synd (disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate and bicarbonate are passed into the urine instead of being reabsorbed)

expired tetracycline

hemorrhagic cystitis

cyclophosphamide ifosfamide **prevent by co-admin w/ mesna

interstitial nephritis

methicillin NSAIDs furosemide

SIADH

cabamazepine | cyclophosphamide

cinchonism (temporary deafness, ringing in the ears, headache, dizziness, and rash)

Quinidine | quinine

parkinson-like synd

antipsychotics reserpine metoclopramide

Seizures

``` Isoniazid Bupropion Imipenem/cilastatin Tramadol Enflurane Metoclopramide ``` "with seizures, I BITE My tongue"

Tardive dyskinesia

antipsychotics

antimuscarinic

atropine TCAs H1 blockers neuroleptics

disulfiram-like rxn

``` metronidazole certain cephalosporins (cefoperazone and cefotetan) procarbazine 1st gen sulfonylureas griseofulvin ```

Nephrotoxicity/otoxicity

aminoglycosides vancomycin loop diuretics cisplatin

blurry yellow vision

digoxin