Drug nutrient interactions

Question 1

what are the effects of drug nutrient interactions on pharmacokinetics?

Answer 1

1. absorption
2. distribution
3. metabolism
4. excretion

Question 2

drug whose absorption is decreased with food

Answer 2

alendronate (fosamax) - bisphosphonate used to prevent bone resorption

Question 3

drug whose absorption is increased with food

Answer 3

ondansetron (zofran) - antiemetic

Question 4

drug that chelates with divalent cations

Answer 4

cipro - BSA

Question 5

how does omeprazole affect nutrient availability?

Answer 5

decrease in nutrient extraction

Question 6

drug responsible for sequestration of nutrients

Answer 6

colestipol - will also sequester fat soluble vitamins and prevent their absorption

Question 7

what is the effect of phenytoin in low protein states?

Answer 7

decreased serum protein levels will alter protein free and protein bound fractions of drug - results in increase in free drug availability

Question 8

how does grapfruit juice impact drug metabolism?

Answer 8

increases bioavailability via inhibition of cyp450 enzymes

Question 9

lithium is what type of cation?

Answer 9

monovalent

Question 10

how does tyramine affect the release of synaptic catecholamine NTs?

Answer 10

increase

Question 11

how do NSAIDS impact PGE2 synthesis?

Answer 11

decrease

Question 12

what is the result of decrease PGE2 synthesis as a result of NSAIDS?

Answer 12

1. increased acid secretion
2. decreased mucus secretion
3. impaired mucosal blood flow

Question 13

how do anticholinergic agents affect intestinal peristalsis?

Answer 13

block Ach mediated smooth muscle contraction

Question 14

what do tricyclic antidepressants do to appetite? how?

Answer 14

1. increase

2. block H1 receptors in CNS

Question 15

what do SSRIs do to appetite? how?

Answer 15

1. decrease

2. increased accumulation of serotonin