Diabetes Pathophysiology Exam 2 Flashcards
What is diabetes
metabolic disorder characterized by HYPERGLYCEMIA that results form defects in insulin secretion, insulin action, or both
where in pancreas does endocrine function occur?
Islet of Langerhans
what do alpha cells do
secrete glucagon in response to low blood sugar
glucagon
stimulates the liver to release stored glucose into the blood
beta cells
produce insulin which lowers glucose levels by stimulating the movement of glucose into body tissues
Insulin
secreted by the pancreas (beta cells), stimulates uptake, utilization, and storage of glucose, stimulates the liver to store glucose (as glycogen)
b/c of stimulating effects– insulin decreases plasma concentrations of glucose
insulin and fat
insulin promotes synthesis of fatty acids in the liver
insulin inhibits the breakdown of fat in the adipose tissue – can cause a buildup of triglycerides in fat cells
when our body begins to break down fat.. what is the by product?
Free Fatty Acid (FFA)
when you breakdown protein what is by product?
amino acids
S/S of hypoglycemia
pallor, sweating, tachycardia, palpitations, hunger, restlessness, anxiety, tremors, convulsion, coma
Somogyi effect
overdose of insulin which causes hypoglycemia and counter regulatory mechanisms cause hyperglycemia and ketosis
liver sense low blood sugar, releases stored glucose = hyperglycemia and ketosis
dawn phenomenon
hyperglycemia in the morning due to natural hormonal release