Anti-fungal Pharmacology Flashcards
what are the four major classes of anti-fungal drugs
polyenes
pyrimidine
azoles
misc. agents
Drugs in polyene class
nystatin and amphotericin b
drugs in pyrimidine
flucytosine
drugs in azoles
fluconazole
MOA for polyene class
binds to ergosterol in fungal cell membranes causes them to become leaky and destroys cell wall of the fungus
indications for nystatin
treatment of superficial candida infections of mouth, oral mucosa, vagina, and skin
indications for amphotericin b
systemic mycoses
side effects for nystatin
not a lot
mild skin irritation; N/V/D when taken orally
poor GI absorption
available forms of nystatin
creams, powder, topical, vaginal
nursing considerations for amphotericin b
monitor BUN and creatinine (can hurt kidneys)
must be on cardiac monitor and frequent VS
must be diluted and infused SLOWLY
MOA for pyrimidine
flucytosine
inhibits fungal DNA synthesis
indication for flucytosine
allows for a lower dose of amphotericin b to be used
helps decrease SE related to amphotericin
MOA for azoles
fluconazole
interrupts the integrity of the cell wall by interfering with the synthesis of ergosterol
indications for fluconazole
both superficial and less serious systemic fungal infections
SE for fluconazole
topical - redness burning itching
systemic - severe GI upset, LIVER toxicity
