DDIs: Additive Effects Flashcards
1
Q
Serotonin Syndrome Symptoms
A
- sweating
- N/V
- fever
- AMS
- rigidity / tremor
- seizure
2
Q
Drugs with additive risk for hyperkalemia
A
- RAAS drugs
- Potassium sparing diuretics (Amiloride, triamterene)
- Salt substitutes (KCl)
- Calcineurin inhibitors (tacrolimus, cyclosporine)
- SMX/TMP
- canagliflozin
- drospirenone containing contraceptives
3
Q
Hyperkalemia symptoms
A
- weakness
- palpitations
- arrhythmia
Note: higher risk with renal impairment
4
Q
QT prolonging anti-infectives
A
- hydroxychloroquine
- azole antifungals
- lefamlin
- macrolides
- quinolones
5
Q
QT prolonging antidepressants
A
- escitalopram & citalopram
- TCAs
- mirtazapime
- trazodone
- venlafaxine
6
Q
QT prolonging antipsychotics
A
- First gen (haloperidol, thioridazine)
- Second gen (highest risk with ziprasidone)
7
Q
QT prolonging Antiemetics
A
- ondansetron
- droperidol
- metoclopramide
- promethazine
8
Q
QT prolonging oncology medications
A
- leuprolide
- nilotinib
- oxaliplatin
9
Q
Misc QT prolonging agents
A
- cilostazol
- donepezil
- fingolimod
- hydroxyzine
- loperamide
- ranolazine
- solifenacin
- methadone
- tacrolimus
10
Q
QT prolongation precaution: Citalopram dosing in pts > 60
A
max 40mg daily
11
Q
QT prolongation precaution: Escitalopram dosing in pts > 60
A
Max 20mg daily
12
Q
Drugs with additive ototoxicity
A
- Aminoglycosides (gentamicin, tobramycin, amikacin)
- Cisplatin
- Loop diuretics (furosemide, bumetanide)
- Aspirin
- Vancomycin
13
Q
Drugs with additive nephrotoxicity
A
- Anti-infectives (aminoglycosides, amphotericin B, polymyxins, vancomycin)
- Cisplatin
- Calcineurin inhibitors (tacrolymus, cyclosporine)
- Loop diuretics
- NSAIDs
- Contrast dye
14
Q
Drugs with additive hypotensive effects
A
PDE-5 inhibitors (sildenafil, tadalafil)
+
CYP3A4 inhibitors
OR
Nitrates
OR
Alpha 1 blockers (doxazosin, terazosin, tamsulosin)
