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NAPLEX Prep > CV drugs COPY > Flashcards

CV drugs COPY Flashcards

1
Q

Nitro-Bid

A

Long acting nitrate
Nitroglycerin ointment 2%
Admin: dosed BID 6 hrs apart w/ 10-12 hr nitrate-free interval

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2
Q

MONA-GAP-BA
M

A

Morphine sulfate -> pain relief
reserved for unacceptable pain/discomfort
has been shown to diminish antiplatelet effects
Dose: 2-5mg IV Q5-30min PRN

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3
Q

How long after PDE-5i’s can nitrates be given?

A

Avanafil (Stendra): 12hrs
Sildenafil (Viagra): 24hrs
Vardenafil: 24hrs
Tadalafil (Cialis): 48hrs

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4
Q

Fibrinolytic characteristics

A

CI:
- active bleed
- recent stroke
- severe uncontrolled HTN
ADE: bleeding
Monitor:
- Hgb
- Hct
- signs of bleeding

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5
Q

Integrilin

A

GP 2b/3b RA
Eptifibatide
ADE: bleeding, thrombocytopenia

reversible blockade- platelet function recovers in 4-8hrs

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6
Q

MONA-GAP-BA
A (MONA)

A

Aspirin
Non-enteric coated, chewable ASA 162-325mg immediately

maintenance dose 81-162 daily indefinitely

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7
Q

Effient Dosing

A

LD: 60mg PO
MD: 10 mg PO daily

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8
Q

Effient

A

P2Y12
Prasugrel
BW: BLEEDING
- not recommended in pts > 75
- stop at least 7 days prior to surgery
- avoid use if CABG likely
CI:
- active bleed
- hx of TIA or stroke
Warnings:
- bleed risk
- TTP
ADE: bleed
Notes:
- Only indicated for ACS managed with PCI
- Dispense in original container

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9
Q

Brillinta

A

P2Y12
Ticagrelor
BW:
- bleeding
- do not exceed 100mg ASA daily d/t reduced ticagrelor effectiveness
- avoid use if CABG likely
- stop 5 days before surgery
CI:
- active bleed
- Hx of intracranial hemorrhage
Warnings:
- bleed risk
- TTP
ADE:
- bleeding
- dyspnea

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10
Q

Plavix Dosing

A

LD: 300-600 mg PO
- 600 for PCI

MD: 75 mg PO daily

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11
Q

NitroMist, Nitrolingual

A

Short acting nitrate
Nitroglycerin TL spray

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12
Q

MONA-GAP-BA
O

A

Oxygen
indicated for patients w/ SaO2 sat < 90% & pts in respiratory distress

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13
Q

MONA-GAP-BA
G

A

GP 2b/3a RAs
Eptifibatide
Tirofiban

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14
Q

Lotrel

A

Benazepril/Amlodipine

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15
Q

Activase

A

Fibrinolytic
Alteplase
MOA: tissue plasminogen activator

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16
Q

MONA-GAP-BA
P

A

P2Y12 inhibitors
Clopidogrel
Prasugrel
Ticagrelor

17
Q

Plavix

A

P2Y12
Clopidogrel
BW: test for CYP2C19 genotype (poor metabolizers will not see full effectiveness from this prodrug)
CI: active bleed
Warnings:
- bleed risk (stop 5d before planned surgery)
- do not use with omeprazole or esomeprazole
- Thrombotic thrombocytopenic purpura (TTP)
ADE:
- bleed risk

18
Q

Ranexa

A

Anti-anginal agent
Ranolazine
Use: substitute for or addition to BB in SIHD maintenance treatment
CI: strong CYP3A4 inhibitors/inducers
Warnings:
- QT prolongation
- acute renal failure when CrCl < 30
ADE: dizziness, HA, constipation, nausea
Notes: not for acute treatment of chest pain

19
Q

Isordil Titradose

A

Long acting nitrate
Isosorbide dinitrate

20
Q

Isodur

A

Long acting nitrate
Isosorbide mononitrate

IR tab: dosed BID, 7 hrs apart

ER tab: daily AM dosing

21
Q

Nitroglycerin clinical characteristics

A

CI: do not use with PDE-5i’s
ADE:
- HA
- flushing
- syncope
- hypotension/dizziness

22
Q

MONA-GAP-BA
B

A

Beta blockers
Metoprolol or carvedilol preferred

contraindications:
- decompensated HF
- cardiogenic shock
- HR < 45 bpm

23
Q

MONA-GAP-BA
A (GAP)

A

Anticoagulants
LMWH (enoxaparin, dalteparin)
UFH
Bivaliruden

UFH & Bivaliruden preferred in STEMI

24
Q

MONA-GAP-BA
N

A

Nitrates
0.4mg SL NTG every 5 minutes x 3 doses

if symptoms persist -> IV NTG
Do not use IV NTG if:
- SBP < 90 mmHg
- HR < 50 bpm
- PDE-5 inhibitor use

25
Q

Nitrostat

A

Short acting nitrate:
Nitroglycerin SL tablets
Store in original amber glass bottle

26
Q

ReoPro

A

GP 2b/3a RA
Abciximab
ADE: bleeding, thrombocytopenia

irreversible blockade- platelet function recovers in 24-48 hrs

only recommended in ACS patients receiving PCI +/- stent

27
Q

Aggrastat

A

GP 2b/3b RA
Tirofiban
ADE: bleeding, thrombocytopenia

reversible blockade- platelet function recovers in 4-8hrs

28
Q

GoNitro

A

Short acting nitrate
Nitroglycerin SL powder

29
Q

TNKase

A

Fibrinolytic
Tenecteplase

30
Q

Nitro-Dur

A

Long acting nitrate
Nitroglycerin transdermal patch
Admin: wear for 12-14hrs, off for 10-12hrs; rotate sites

31
Q

Preferred stable angina maintenance treatment in HFrEF

A

Isosorbide dinitrate + Hydralazine

32
Q

Long acting nitrates notes

A

Require a 10-12 hr nitrate-free interval to reduce tolerance

Patch: wear for 12-14hrs, off for 10-12hrs; rotate sites

Ointment: dosed BID 6 hrs apart w/ 10-12 hr nitrate-free interval

33
Q

MONA-GAP-BA
A (BA)

A

ACE inhibitor
start within first 24hrs & continue indefinitely in pts w/ LVEF < 40%, HTN, diabetes, or stable CKD.

use ARB if pt is ACE intolerant

do not use IV ACE within the first 24 hrs due to risk of hypotension

34
Q

Brilinta Dosing

A

LD: 180 mg PO
MD: 90mg PO BID x 1 year then 60mg PO BID

NAPLEX Prep (40 decks)

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