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Chemo drugs Flashcards

1
Q

Cyclophosphamide

A

Alkylating agent
Brand name: Cytoxan
Boxed warnings:
- Hemorrhagic cystitis (hydrate & give Mesna with high doses)

Warnings:
- Rash (SJS/TEN)
- Reactivation of infections
- Hepatotoxicity

ADE:
- SIADH
- Moderate-High emetic risk
- Mucositis
- Alopecia
- Secondary malignancies
- Neurotoxicity

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2
Q

Ifosfamide

A

Alkylating agent
Brand name: Ifex
Boxed Warning:
- Hemorrhagic cystitis (hydrate & give Mesna with ALL DOSES
- Neurotoxicity

Warnings:
- Rash (SJS/TEN)
- reactivation of infections
- hepatotoxicity

ADE:
- Moderate-High emetic risk
- Mucositis
- Alopecia
- Secondary malignancies

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3
Q

Carmustine

A

Alkylating agent
Brand name: BiCNU, Gliadel Wafer

Admin: Non-PVC bag and tubing

Boxed Warnings:
- Pulmonary toxicity

Warnings:
- Rash (SJS/TEN)
- reactivation of infections
- Hepatotoxicity

ADE:
- Moderate-high emetic risk
- Mucositis
- Alopecia
- Secondary malignancies
- Neurotoxicity

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4
Q

Busulfan

A

Alkylating agent
Brand name: Myleran

Warnings:
- Rash (SJS/TEN)
- Reactivation of infections
- Hepatotoxicity

ADE:
- Pulmonary toxicity
- Moderate-High emetic risk
- Mucositis, alopecia, secondary malignancies, neurotoxicity

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5
Q

Cisplatin

A

Platinum-based compound
Brand name: Kemoplat
Caution with doses > 100 mg/m^2/cycle
Boxed Warnings:
- Anaphylactic-like-rxn
- Nephrotoxicity (protectant: Amifostine (Ethyol))
- Ototoxicity

CI:
- pre-existing renal impairment, hearing impairment, myelosuppression

ADE:
- Peripheral neuropathy (cumulative, dose related)
- High emetic risk
- QT prolongation

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6
Q

Carboplatin

A

Platinum-based compound
Brand name: Paraplatin
Boxed Warnings:
- Anaphylactic-like rxn (caution with > 6 cycles)
ADE:
- peripheral neuropathy (cumulative, dose related)
- High emetic risk
- QT prolongation

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7
Q

Alkylating agent
Brand name: Cytoxan

A

Cyclophosphamide

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8
Q

Alkylating agent
Brand name: Ifex

A

Ifosfamide

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9
Q

Alkylating agent
Brand name: BiCNU, Gliadel Wafer

A

Carmustine

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10
Q

Alkylating agent
Brand name: Myleran

A

Busulfan

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11
Q

Platinum-based compound
Brand name: Kemoplat

A

Cisplatin

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12
Q

Platinum-based compound
Brand name: Paraplatin

A

Carboplatin

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13
Q

Doxorubicin

A

Anthracycline
Brand name: Adriamycin

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14
Q

Mitoxantrone

A

Anthracycline
Brand name: None?

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15
Q

Irinotecan

A

Topoisomerase I inhibitor
Brand name: Camptosar

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16
Q

Bleomycin

A

Topoisomerase II inhibitor
Brand name: None?

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17
Q

Anthracycline
Brand name: Adriamycin

A

Doxorubicin

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18
Q

Anthracycline
Brand name: None?

A

Mitoxantrone

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19
Q

Topoisomerase I inhibitor
Brand name: Camptosar

A

Irinotecan

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20
Q

Topoisomerase II inhibitor
Brand name: None?

A

Bleomycin

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21
Q

Vincristine

A

Vinca alkaloid
Brand name: Vincasar PFS

22
Q

Vinblastine

A

Vinca Alkaloid
Brand name: None?

23
Q

Paclitaxel

A

Taxanes
Brand name: none for conventional
Abraxane (albumin-bound formulation)

24
Q

Docetaxel

A

Taxanes
Brand name: Taxotere

25
Vinca alkaloid Brand name: Vincasar PFS
Vincristine
26
Vinca Alkaloid Brand name: None?
Vinblastine
27
Taxanes Brand name: none for conventional Abraxane (albumin-bound formulation)
Paclitaxel
28
Taxanes Brand name: Taxotere
Docetaxel
29
Fluorouracil "5-FU'
Pyrimidine analog antimetabolite Brand name: Efudex
30
Capecitabine
Pyrimidine analog antimetabolites Brand name: Xeloda
31
Methotrexate
Folate antimetabolites Brand name: Trexall
32
Bevalcizumab
VEGF inhibitor Brand name: Avastin
33
Trastuzumab
HER2 inhibitor Brand name: Herceptin
34
Cetuximab
EGFR inhibitor Brand name: Erbitux
35
Imatinib
TKI Brand name: Gleevec
36
Pyrimidine analog antimetabolite Brand name: Efudex
Fluorouracil "5-FU'
37
Pyrimidine analog antimetabolites Brand name: Xeloda
Capecitabine
38
Folate antimetabolites Brand name: Trexall
Methotrexate
39
VEGF inhibitor Brand name: Avastin
Bevalcizumab
40
HER2 inhibitor Brand name: Herceptin
Trastuzumab
41
EGFR inhibitor Brand name: Erbitux
Cetuximab
42
TKI Brand name: Gleevec
Imatinib
43
Tamoxifen
Selective Estrogen Receptor Modulator (SERM) Brand name: APO-tamox
44
Anastrazole
Aromatase inhibitor Brand name: Arimidex
45
Rituximab
CD inhibitor Brand name: Rituxan
46
Leuprolide
GnRH agonist Brand name: Lupron Depot
47
Goserelin
GnRH agonist Brand name: Zoladex
48
Selective Estrogen Receptor Modulator (SERM) Brand name: APO-tamox
Tamoxifen
49
Aromatase inhibitor Brand name: Arimidex
Anastrazole
50
CD inhibitor Brand name: Rituxan
Rituximab
51
GnRH agonist Brand name: Lupron Depot
Leuprolide
52
GnRH agonist Brand name: Zoladex
Goserelin

NAPLEX Prep (40 decks)

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