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NAPLEX Prep > Chemo drugs > Flashcards

Chemo drugs Flashcards

1
Q

Cyclophosphamide

A

Alkylating agent
Brand name: Cytoxan
Boxed warnings:
- Hemorrhagic cystitis (hydrate & give Mesna with high doses)

Warnings:
- Rash (SJS/TEN)
- Reactivation of infections
- Hepatotoxicity

ADE:
- SIADH
- Moderate-High emetic risk
- Mucositis
- Alopecia
- Secondary malignancies
- Neurotoxicity

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2
Q

Ifosfamide

A

Alkylating agent
Brand name: Ifex
Boxed Warning:
- Hemorrhagic cystitis (hydrate & give Mesna with ALL DOSES
- Neurotoxicity

Warnings:
- Rash (SJS/TEN)
- reactivation of infections
- hepatotoxicity

ADE:
- Moderate-High emetic risk
- Mucositis
- Alopecia
- Secondary malignancies

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3
Q

Carmustine

A

Alkylating agent
Brand name: BiCNU, Gliadel Wafer

Admin: Non-PVC bag and tubing

Boxed Warnings:
- Pulmonary toxicity

Warnings:
- Rash (SJS/TEN)
- reactivation of infections
- Hepatotoxicity

ADE:
- Moderate-high emetic risk
- Mucositis
- Alopecia
- Secondary malignancies
- Neurotoxicity

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4
Q

Busulfan

A

Alkylating agent
Brand name: Myleran

Warnings:
- Rash (SJS/TEN)
- Reactivation of infections
- Hepatotoxicity

ADE:
- Pulmonary toxicity
- Moderate-High emetic risk
- Mucositis, alopecia, secondary malignancies, neurotoxicity

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5
Q

Cisplatin

A

Platinum-based compound
Brand name: Kemoplat
Caution with doses > 100 mg/m^2/cycle
Boxed Warnings:
- Anaphylactic-like-rxn
- Nephrotoxicity (protectant: Amifostine (Ethyol))
- Ototoxicity

CI:
- pre-existing renal impairment, hearing impairment, myelosuppression

ADE:
- Peripheral neuropathy (cumulative, dose related)
- High emetic risk
- QT prolongation

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6
Q

Carboplatin

A

Platinum-based compound
Brand name: Paraplatin
Boxed Warnings:
- Anaphylactic-like rxn (caution with > 6 cycles)
ADE:
- peripheral neuropathy (cumulative, dose related)
- High emetic risk
- QT prolongation

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7
Q

Alkylating agent
Brand name: Cytoxan

A

Cyclophosphamide

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8
Q

Alkylating agent
Brand name: Ifex

A

Ifosfamide

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9
Q

Alkylating agent
Brand name: BiCNU, Gliadel Wafer

A

Carmustine

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10
Q

Alkylating agent
Brand name: Myleran

A

Busulfan

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11
Q

Platinum-based compound
Brand name: Kemoplat

A

Cisplatin

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12
Q

Platinum-based compound
Brand name: Paraplatin

A

Carboplatin

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13
Q

Doxorubicin

A

Anthracycline
Brand name: Adriamycin

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14
Q

Mitoxantrone

A

Anthracycline
Brand name: None?

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15
Q

Irinotecan

A

Topoisomerase I inhibitor
Brand name: Camptosar

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16
Q

Bleomycin

A

Topoisomerase II inhibitor
Brand name: None?

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17
Q

Anthracycline
Brand name: Adriamycin

A

Doxorubicin

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18
Q

Anthracycline
Brand name: None?

A

Mitoxantrone

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19
Q

Topoisomerase I inhibitor
Brand name: Camptosar

A

Irinotecan

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20
Q

Topoisomerase II inhibitor
Brand name: None?

A

Bleomycin

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21
Q

Vincristine

A

Vinca alkaloid
Brand name: Vincasar PFS

22
Q

Vinblastine

A

Vinca Alkaloid
Brand name: None?

23
Q

Paclitaxel

A

Taxanes
Brand name: none for conventional
Abraxane (albumin-bound formulation)

24
Q

Docetaxel

A

Taxanes
Brand name: Taxotere

25
Q

Vinca alkaloid
Brand name: Vincasar PFS

A

Vincristine

26
Q

Vinca Alkaloid
Brand name: None?

A

Vinblastine

27
Q

Taxanes
Brand name: none for conventional
Abraxane (albumin-bound formulation)

A

Paclitaxel

28
Q

Taxanes
Brand name: Taxotere

A

Docetaxel

29
Q

Fluorouracil “5-FU’

A

Pyrimidine analog antimetabolite
Brand name: Efudex

30
Q

Capecitabine

A

Pyrimidine analog antimetabolites
Brand name: Xeloda

31
Q

Methotrexate

A

Folate antimetabolites
Brand name: Trexall

32
Q

Bevalcizumab

A

VEGF inhibitor
Brand name: Avastin

33
Q

Trastuzumab

A

HER2 inhibitor
Brand name: Herceptin

34
Q

Cetuximab

A

EGFR inhibitor
Brand name: Erbitux

35
Q

Imatinib

A

TKI
Brand name: Gleevec

36
Q

Pyrimidine analog antimetabolite
Brand name: Efudex

A

Fluorouracil “5-FU’

37
Q

Pyrimidine analog antimetabolites
Brand name: Xeloda

A

Capecitabine

38
Q

Folate antimetabolites
Brand name: Trexall

A

Methotrexate

39
Q

VEGF inhibitor
Brand name: Avastin

A

Bevalcizumab

40
Q

HER2 inhibitor
Brand name: Herceptin

A

Trastuzumab

41
Q

EGFR inhibitor
Brand name: Erbitux

A

Cetuximab

42
Q

TKI
Brand name: Gleevec

A

Imatinib

43
Q

Tamoxifen

A

Selective Estrogen Receptor Modulator (SERM)
Brand name: APO-tamox

44
Q

Anastrazole

A

Aromatase inhibitor
Brand name: Arimidex

45
Q

Rituximab

A

CD inhibitor
Brand name: Rituxan

46
Q

Leuprolide

A

GnRH agonist
Brand name: Lupron Depot

47
Q

Goserelin

A

GnRH agonist
Brand name: Zoladex

48
Q

Selective Estrogen Receptor Modulator (SERM)
Brand name: APO-tamox

A

Tamoxifen

49
Q

Aromatase inhibitor
Brand name: Arimidex

A

Anastrazole

50
Q

CD inhibitor
Brand name: Rituxan

A

Rituximab

51
Q

GnRH agonist
Brand name: Lupron Depot

A

Leuprolide

52
Q

GnRH agonist
Brand name: Zoladex

A

Goserelin

NAPLEX Prep (40 decks)

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