Commonly used drugs for specific pathogens

Question 1

MSSA

Answer 1

Dicloxacillin, Nafcillin, Oxacillin
1st & 2nd gen cephalosporins
Amox/Clav, Amp/Sul

Question 2

MRSA

Answer 2

Vancomycin
Linezolid
Daptomycin (not pneumonia)
Ceftaroline
SMX/TMP (CA MRSA SSTIs)
Doxycycline, minocycline (CA MRSA SSTIs)
Clindamycin (CA-MRSA SSTIs)

Question 3

Vancomycin resistant enterococcus (VRE)

Answer 3

Pen G or ampicillin (E. faecalis only)
Linezolid
Daptomycin
Cystitis only: nitrofurantoin, fosfomycin, doxycycline

Question 4

Atypical organisms

Answer 4

Azithromycin, clarithromycin
doxycycline, minocycline
quinolones

Question 5

HNPEK

Answer 5

beta-lactam/beta-lactamase inhibitor
cephalosporins (except 1st gen)
carbapenems
aminoglycosides
quinolones
SMX/TMP

Question 6

Pseudomonas aeruginosa

Answer 6

Piperacillin/Tazobactam
Cefepime
Ceftazidime
Ceftazidime/avibactam
Ceftolozane/tazobactam
Carbapenems (except ertapenem)
Ciprofloxacin, levofloxacin
Aztreonam
Tobramycin
Colistimethate, polymyxin B

Question 7

CAPES

Answer 7

Piperacillin/tazobactam
cefepime
carbapenems
aminoglycosides
colistimethate, polymyxin B

Question 8

Extended spectrum beta-lactamase producing gram negative rods (ESBL):
- E. coli
- K. pneumoniae
- P. mirabillis

Answer 8

Carbapenems
Ceftazidime/avibactam
Ceftolozone/tazobactam

Question 9

Carbapenem-resistant gram negative rods (CRE)

Answer 9

Ceftazidime/avibactam
Colistimethate, polymyxin B
Meropenem/vaborbactam
Imipenem/cilastatin/relebactam

Question 10

Gram negative anaerobes (B. fragilis)

Answer 10

Metronidazole
Beta-lactam/ BLI
Cefotetan, cefoxitin
Carbapenems
Moxifloxacin (reduced activity)

Question 11

C. difficile

Answer 11

Vancomycin
Fidaxomicin
Metronidazole