Crohns disease and ulcerative colitis Flashcards
What ages are more susceptible to IBD? (2 points)
- 15-25 years
- 50-80 years
Are males or females more susceptible to Crohn’s disease?
- Males
Are males or females more susceptible to ulcerative colitis?
- Females
What are the possible causes of IBD? (4 points)
- Immunological
- Psychological
- Smoking (reduces chances of IBD)
- Genetic
What are immunological causes of IBD?
- People who seem to be predisposed due to the way they have an immune response
What are psychological causes of IBD?
- IBD could be a consequence of psychological factors nut not very clear
Does smoking increase or decrease the chances of someone getting IBD?
- Decreases
Are there genetic causes of IBD?
- Yes, there is a clear tendency that it runs in families
- You are at a slightly higher risk if your parents have it
What is the histology of Crohn’s disease?
- Histologically there are granulomas inside the tissue (collection of multi-nucleated giant cells that form together in a clump) (granulomatous inflammation)
- Something is happening in the tissues which is causing immune stimulation which the body is unable to deal with
What can cause Crohn’s disease? (2 causes)
- Food intolerance (something passing through the gut which is causing irritation e.g. benzoic acid)
- Persisting viral infection/immune activation
What is Johne’s disease?
- Problem which cattle get which is similar to Crohn’s disease
Where in the body can you fins Crohn’s disease?
- Any part of the bowel from the mouth all the way down to the bottom end
Where are 3 common places to find Crohn’s disease?
- Mouth
- Ileo-caecal region
- Rectum
Where is ulcerative colitis found and where does it originate from?
- Found ONLY in colon
- Always starts in rectum and works its way up
- If starts anywhere else it is not this
In relation to Ulcerative colitis and Crohn’s disease, which is continuous and which is discontinuous?
- UC = continuous
- CD = discontinuous
In relation to Ulcerative colitis and Crohn’s disease, when is the rectum involved?
UC = always
CD = 50% of the time
In relation to Ulcerative colitis and Crohn’s disease, when do they have anal fissures?
UC = 25% of the time
CD = 75% of the time
In relation to Ulcerative colitis and Crohn’s disease, when is the ileum involved?
UC = 10%
CD = 30%
In relation to Ulcerative colitis and Crohn’s disease, what is the mucosa like?
UC = Granulomas and ulcers
CD = Cobbled and fissures
In relation to Ulcerative colitis and Crohn’s disease, are they vascular?
UC = Vascular
CD = non-vascular
In relation to Ulcerative colitis and Crohn’s disease, what is the serosa like?
UC = normal
CD = inflamed
What are the microscopic features of ulcerative colitis? (3 points)
- Mucosal
- Vascular
- Mucosal abscesses
What are the microscopic features of Crohn’s disease? (3 points)
- Transmural
- Oedematous
- Granulomas (in the gut)
In relation to Ulcerative colitis and Crohn’s disease, where are they inflamed?
UC = Very superficial
CD = Entire thickness of the bowel wall inflamed (narrows lumen)
