Complement

Question 1

How is the classical pathway activated?

Answer 1

This is activated from an antibody (IgG or IgM) coated microbial surface.

Question 2

How is the lectin pathway activated?

Answer 2

This is activated by mannose-binding lectin complex

Question 3

How is the alternative pathway activated?

Answer 3

This is activated by C3b coated pathogen.

Question 4

What are the three pathways for complement?

Answer 4

Alternative
Classical
Lectin

Question 5

What do the three pathways all converge at?

Answer 5

C3 convertase

Question 6

C3 convertase will cause the activation of C3a and C5a. What affect will this have?

Answer 6

These are peptide mediators of inflammation through C3a receptor and C5a receptor- mediated activation of leukocytes.

Question 7

C3 convertase will cause the activation of C3b, what affect does this have?

Answer 7

This will opsonize the pathogen. This will bind to complement receptors on the pathogen.

Question 8

C3b will cause the activation or C5b, C6, C7, C8 and C9. What is the effect of this?

Answer 8

This will create a membrane-attack complex. This will cause lysis of pathogens and cells.