Coeliac Disease Flashcards
What is coeliac disease?
Gluten sensitive autoimmune disease of the small intestine
What is the pathophysiology of coeliac disease?
T cell mediated
Autoantibodies against tissue transglutaminase
Epithelial cell destruction
Villous atrophy
What are the types of coeliac disease?
Classical form
Atypical form
Latent form
Silent form
What is the classical form?
Appears 9-24 months
Malabsorption
- failure to thrive
- GI symptoms
Histology = crypt hyperplasia + villous atrophy
What is the atypical form?
No intestinal features
Positive coeliac serology
What is the latent form?
Predisposing gene HLADQ2
Positive serology
What is the silent form?
No clinical symptoms
What extra intestinal features can appear in coeliac disease?
Dermatitis herpetiformis Enamal hypoplasia Osteoporosis Delayed puberty Iron deficiency anaemia
How is suspected coeliac disease investigated?
Serology
- anti-TTG
- IgA
Duodenal biopsy
How long do patients need to be gluten free before coeliac serology is done?
6 weeks
How is coeliac disease managed?
Gluten free diet
