coagulation lab and what it assesses

Question 1

aPTT asses which pathways

Answer 1

intrinsic and final common pathways

Question 2

aPTT measures the time it takes to form a clot using

Answer 2

phospholipid, calcium, and an activator

Question 3

aPTT monitors the therapeutic response to which drug?

Answer 3

unfractionated heparin (but NOT LMWH)

Question 4

normal value of aPTT

Answer 4

25-32 seconds

Question 5

because the intrinsic pathway is slower than the extrinsic pathway, the normal value of ____ will be longer than the normal value of ___

Answer 5

aPTT will be longer than PT

Question 6

factors must be reduced more than ___% for a change in aPTT or PT to be observed

Answer 6

30%

Question 7

which pathways does PT assess

Answer 7

extrinsic and final common pathways

Question 8

PT measures the time it takes to form a clot using

Answer 8

tissue factor and calcium

Question 9

PT monitors the therapeutic response to which drug?

Answer 9

warfarin

Question 10

normal PT value

Answer 10

12-14 seconds

Question 11

the international normalized ratio (INR) is calculation that standardizes

Answer 11

PT results. its based on the ratio of the patients PT and the standard mean PT

Question 12

normal INR value in healthy patients

Answer 12

~1

Question 13

target INR for patients on warfarin

Answer 13

2-3 times the control

Question 14

which lab guides heparin dosing

Answer 14

ACT

Question 15

normal ACT value

Answer 15

90-120 seconds

Question 16

ACT is measured during which times of heparin administration

Answer 16

before, 3 minutes after, and every 30 minutes thereafter

Question 17

the ACT tends to be more accurate than which other lab in the setting of large heparin doses?

Answer 17

PTT

Question 18

platelet count measures

Answer 18

the number of platelets but not how well they function

Question 19

what platelet count increases surgical bleeding risk

Answer 19

<50k

Question 20

what platelet count increases spontaneous bleeding risk?

Answer 20

<20k

Question 21

what does bleeding time monitor/evaluate

Answer 21

platelet function and the ability to form a platelet plug

Question 22

normal bleeding time value

Answer 22

2-10 minutes

Question 23

which 2 drugs prolong bleeding time

Answer 23

ASA and NSAIDS

Question 24

what does D-dimer monitor for

Answer 24

fibrinolysis via fibrin degradation products

Question 25

normal value of d dimer

Answer 25

<500mg/dL

Question 26

what should be included in your differential if D dimer is increased?

Answer 26

DVT, PE, DIC

Question 27

R time on TEG, what it represents

Answer 27

6-8m, time to begin forming clot

Question 28

if R time is suffering, what is the problem area and treatment

Answer 28

problem area is clotting factors and tx is FFP

Question 29

K time on TEG, what it represents

Answer 29

3-7m, time until clot has achieved fixed strength

Question 30

if K time is suffering, what is the problem area and treatment?

Answer 30

problem area is fibrinogen and treatment is cryo

Question 31

alpha angle on TEG, what it represents

Answer 31

50-60s, speed of fibrin accumulation

Question 32

if alpha angle is suffering, what is the problem area and treatment?

Answer 32

problem area is fibrinogen and treatment is cryo

Question 33

max amplitude on TEG, what it represents

Answer 33

50-60m, highest vertical amplitude on TEG, measures clot strength

Question 34

if max amplitude is suffering, what is the problem area and treatment?

Answer 34

problem area is platelets and treatment is platelets +/- DDAVP

Question 35

a60 on TEG and what it represents

Answer 35

max amplitude (MA) minus 5, represents highest verticle amplitude 30m after max amplitude

Question 36

if a60 on TEG is suffering, what is the problem area and treatment?

Answer 36

problem area ix excess fibrinolysis and treatment is TCA or ACA