Chronic Inflammation Flashcards
List the 4 cells involved in chronic inflammation
- Lymphocytes
- Macrophages
- Plasma cells
- Fibroblasts
What are the two different ways chronic inflammation can develop?
- From acute inflammation
- As a primary lesion
What is the process of it arising from acute inflammation?
- Large damage
- Inability to remove debris
- Failure to resolve
What are examples of chronic inflammation arising as a primary lesion?
- Autoimmune diseases
- Digestive resistant material
- Exogenous substances
- Endogenous substance
What are examples of exogenous substances?
- Sutures
- Glass
What are examples of endogenous substances?
- Keratin
- Hair
- Necrotic tissue
What 2 other things, disregarding scarring, can chronic inflammation result in?
- Fibrosis
- Granuloma formation
State 5 things that promote healing and repair
- Cleanliness
- Apposition of edges (suture)
- Good nutrition
- Metabolic stability
- Normal inflammatory functions
State 6 things that inhibit proper repair and healing
- Dirty wound
- Gaping wound
- Haemophilia
- Poor nourishment
- Abnormal CHO metabolism, diabetes
- Inhibition of angiogenesis
What vitamin deficiencies can result in poor healing
Vitamin C
Vitamin A
What systemic effects does TB cause?
- Malaise
- Cachexia
What is autoimmune thyrodosis an example of?
Loss of function
What is a plasma cell?
Mature B cell in circulation
What do macrophages produce in response to viruses?
Interferon
What are fibroblasts?
- Metabolically active cells
- Assemble structural proteins
What is produced during granulomatous inflammation?
Granulomas in tissue/organs
What is idiopathic disease?
Disease which we don’t know the aetiology of
How are granulomas formed?
- They surround giant cells which come about in response to an indigestible antigen/exogenous or endogenous substance
What are granulomas normally surrounded by?
- Lymphocytes
What immune cells do granulomas contain?
- Neutrophils
- Eosinophils
What type of hypersensitivity are granulomas?
Type 4
What do giant cells consist of
- Macrophages fused together
Structure of a giant cell?
- Large cytoplasm
- Multinucleate
What is langhans giant cell usually found in?
TB
