Antifungals Flashcards
1
Q
Name the 4 types of antifungals?
A
- Polyenes
- Azoles
- Allyamines
- Echinocandins
2
Q
What do polyenes work on?
A
- Bind to ergosterol
3
Q
Give the two polyenes used today
A
- Amphotericin B
- Nystatin
4
Q
What is amphotericin B used to treat
A
Serious systemic fungal infections
5
Q
Why is amphotericin B a last resort?
A
It’s INCREDIBLY toxic
6
Q
How is nystatin administered?
A
- Topically onto infection site
- Orally
7
Q
How do azoles work?
A
- Inhibit ergosterol synthesis
8
Q
What are the 2 imidazoles?
A
- Miconazole
- Ketoconazole
9
Q
What are the three triazoles?
A
- Fluconazole
- Itraconazole
- Voriconazole
10
Q
What is fluconazole used to treat?
A
Yeast infections
11
Q
What is itraconazole used to treat?
A
- Dermatophytes
- Aspergillus
12
Q
What is voriconazile used to treat?
A
Aspergillus
13
Q
How do allyamines work?
A
Also inhibit ergosterol synthesis
14
Q
What is the only used allyamine?
A
Terbinafine
15
Q
What is terbinafine used to treat?
A
Dermatophytes
