Antifungals Flashcards
Name the 4 types of antifungals?
- Polyenes
- Azoles
- Allyamines
- Echinocandins
What do polyenes work on?
- Bind to ergosterol
Give the two polyenes used today
- Amphotericin B
- Nystatin
What is amphotericin B used to treat
Serious systemic fungal infections
Why is amphotericin B a last resort?
It’s INCREDIBLY toxic
How is nystatin administered?
- Topically onto infection site
- Orally
How do azoles work?
- Inhibit ergosterol synthesis
What are the 2 imidazoles?
- Miconazole
- Ketoconazole
What are the three triazoles?
- Fluconazole
- Itraconazole
- Voriconazole
What is fluconazole used to treat?
Yeast infections
What is itraconazole used to treat?
- Dermatophytes
- Aspergillus
What is voriconazile used to treat?
Aspergillus
How do allyamines work?
Also inhibit ergosterol synthesis
What is the only used allyamine?
Terbinafine
What is terbinafine used to treat?
Dermatophytes
How do echinocandins work?
Inhibit synthesis of glucan polysaccharide
Name the 3 echinocandins
- Caspofungin
- Mycafungin
- Anidulafungin
What do the 3 echinocandins treat?
- Candida spp
- Aspergillus spp
