Antivirals

Question 1

What is the mode of action of all antivirals?

Answer 1

Virustatic

Question 2

What are 4 examples of herpes viruses?

Answer 2

• HSV
• Varicella zoster
• Epstein barr
• Cytomegalovirus

Question 3

What is acyclovir an example of?

Answer 3

Nucleoside analogue

Question 4

What can acyclovir be used to treat?

Answer 4

• Herpes simplex virus

- Varicella zoster virus

Question 5

How is acyclovir administered?

Answer 5

• Topically

- IV for serious infection

Question 6

What is the difference between famcyclovir/valacyclovir and acyclovir?

Answer 6

• Same action against same pathogens

- Better bioavailability when taken orally

Question 7

What is ganciclovir and valgancyclovir used against?

Answer 7

Cytomegalovirus

Question 8

What is foscarnet used against?

Answer 8

• HSV
• VZV
• CMV

Question 9

Why does the use of foscarnet need to be monitored?

Answer 9

Very nephrotoxic

Question 10

When is cidofovir used?

Answer 10

When use of the others is not practical

Question 11

What is the first HIV drug used?

Answer 11

AZT

Question 12

What is AZT an example of

Answer 12

Nucleoside analogue that inhibits reverse transcriptase

Question 13

What is AZT used alongside in the treatment of HIV

Answer 13

• 1 other nucleoside analogue reverse transcriptase inhibitors
• A non nucleoside analogue transcriptase inhibitor
  OR
• A protease inhibitor such as saquinavir

Question 14

What drug is used to treat chronic hep B and C

Answer 14

Interferon A with Ribavarin

Question 15

What drug is used to treat Influenza A or B

Answer 15

Zanamavir/Oseltamavir

Question 16

What drug is used to treat respiratory syncitial virus?

Answer 16

Ribavarin