Chapter 5 Flashcards
fluid mosaic model
proteins float in the phospholipid bilayer membrane
Where are most of the proteins in relation to the membrane?
noncovalently embedded in the phospholipid bilayer
What are the functions of membrane proteins?
~move materials through the membrane
~intercellular recognition and adhesion
~receive chemical signals from the cell’s external environment
Where are the membrane carbohydrates found?
attached to lipids or protein molecules
What are the functions of membrane carbohydrates?
recognising specific molecules, such as those on the surface of adjacent cells
phospholipids
the lipids in biological membranes with both hydrophilic and hydrophobic regoins
hydrophilic regions in phospholipids
the phosphorus-containing “head” of a phospholipid is electrically charged and therefore associates with polar water molecules
hydrophobic regions in phospholipids
the long, nonpolar fatty acid “tails” of a phospholipid associate with other nonpolar materials, but they do not dissolve in water or associate with hydrophilic substances
How do phospholipids coexist with water?
They form a bilayer, where the fatty acid “tails” interact with each other and the polar “heads” face the outside, aqueous environment
most common fatty acids in membranes
chains with 16-18 carbon atoms and 0-2 double bonds
saturated fatty acid chains
no double bonds, allow for close packing
unsaturated fatty acid chains
double bonds, “kinks” make for a less dense, more fluid packing
steroid
a family of carbon compounds that have multiple linked rings
cholesterol
a steroid that plays an important role in modulating membrane fluidity
What are the factors that affect membrane fluidity?
lipid composition and temperature (among others)
How does lipid composition affect membrane fluidity?
Saturated fatty acids pack tightly together while unsaturated fatty acids or those with shorter chains increase membrane fluidity. Anaesthetics inserted into cell membranes reduce the fluidity of nerve cell membranes and thereby decrease nerve activity.
How does temperature affect membrane fluidity?
Membrane fluidity declines under cold conditions because molecules move more slowly at lower temperatures. Some organisms change lipid composition of their membranes when it gets cold.
What is the typical ratio between proteins and phospholipids in cell membranes?
1 protein molecule for every 25 phospholipid molecules
What determines how a membrane protein will be positioned relative to the bilayer?
The arrangement of the amino acids in the membrane protein
What are the two general types of membrane proteins?
peripheral and integral
peripheral membrane proteins
lack exposed hydrophobic groups and are not embedded in the bilayer
integral membrane proteins
at least partly embedded in the phospholipid bilayer, and have both hydrophilic and hydrophobic regions
anchored membrane proteins
membrane proteins that have fatty acids or other lipid groups covalently attached to them
transmembrane protein
an integral membrane protein that extends all the way through the phospholipid bilayer and protrudes on both sides
What happens when two cells fuse?
a single continuous membrane forms around both cells, and some proteins from each cell distribute themselves uniformly around this membrane
glycolipid
consists of a carbohydrate covalently bonded to a lipid
glycoprotein
consists of one or more short carbohydrate chains covalently bonded to a protein