Chapter 27: Antilipemic Drugs

Question 1

very effective when combined with aspirin (ASA) and proper titration

Answer 1

niacin

Question 2

Three side effects of niacin include facial ____________, feeling of ________, and ___________ of hands and feet.

Answer 2

flushing, warmth, tingling

Question 3

___________ is a nonpharmacologic method that reduces cholesterol and increases HDL

Answer 3

Exercise

Question 4

Nonpharmacologic methods for cholesterol should be initiated (before, after) drug administration and include reducing ________ and _________, choosing ______ meats such as chicken and fish, reducing total fat intake to ___% or less, and reducing cholesterol intake to _____ mg/day or less.

Answer 4

before, saturated fats, cholesterol, lean, 30, 300

Question 5

lipoprotein that contains higher percentage of cholesterol

Answer 5

low-density lipoprotein (LDL)

Question 6

inhibit namesake enzyme in cholesterol biosynthesis to decrease LDL and increase HDL

Answer 6

HMG CoA reductase inhibitors (statins)

Question 7

monitor ____ levels for myopathy

Answer 7

CK

Question 8

four side effects of HMG CoA reductase inhibitors (statins)

Answer 8

hepatotoxicity
rhabdomyolysis
peripheral neuropathy
cataract formation

Question 9

increases risk of bleeding when used with warfarin

Answer 9

gemfibrozil

Question 10

this drug is taken 30 minutes before breakfast and dinner

Answer 10

gemfibrozil

Question 11

contraindicated in patients with gout, liver disease, and peptic ulcer disease

Answer 11

niacin

Question 12

drug that is recommended when triglycerides are over 500 mg/dL or intolerant to other treatment options

Answer 12

niacin

Question 13

Diet alone only reduces total cholesterol by _______%

Answer 13

10-30

Question 14

drug that primarily decreases triglyceride levels

Answer 14

gemfibrozil

Question 15

lipoprotein that contains mostly triglycerides and less cholesterol

Answer 15

very low-density lipoprotein (VLDL)

Question 16

HMG CoA reductase inhibitors are dosed in the _____________ because cholesterol is synthesized at ______ (times)

Answer 16

evening, night

Question 17

cholesterol medications are taken (temporarily, for a lifetime)

Answer 17

for a lifetime

Question 18

drug that reduces cholesterol and increases HDL

Answer 18

niacin

Question 19

this drug has numerous side effects resulting in only 20% of patients being able to take it

Answer 19

niacin

Question 20

___________ is a lifestyle choice that increases LDL and decreases HDL

Answer 20

Smoking

Question 21

lipoprotein that removes cholesterol from blood and transports it to liver for elimination

Answer 21

high-density lipoprotein (HDL)

Question 22

limit grapefruit juice with this drug

Answer 22

HMG CoA reductase inhibitors

Question 23

two side effects of gemfibrozil

Answer 23

gallstones
myopathy