Chapter 23 and 24 Cancer Flashcards

1
Q

Benign tumor cells

A

These cells do not invade, the don’t migrate, and have orderly growth

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2
Q

tumor angiogenesis factor (TAF)

A

When tumor is 1 cm

triggers capillaries and other blood vessels in the area to grow new branches into the tumor

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3
Q

Bloodborne metastasis

A

most common cause of cancer spread

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4
Q

Gx

A

grade can not be determined

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5
Q

G1

A

tumor cells are well differentiated and closely resemble the normal cells from which they arose

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6
Q

G2

A

tumor cells are moderately differentiated- they still retain some of the characteristics of normal cells

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7
Q

G3

A

tumor cells are poorly differentiated and retain no normal cell characteristics

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8
Q

Ploidy

A

the description of cancer cells by chromosome number and appearance. Normal human cells have 46

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9
Q

TNM system

A

Tumor, node, metastasis system describes the anatomic extent of cancers
not useful for leukemia or lymphomas.

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10
Q

Tx

A

Primary tumor cannot be assessed

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11
Q

T0

A

no evidence of primary tumor

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12
Q

Tis

A

carcinoma in situ (in its natural or original place)

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13
Q

Nx

A

regional lymph nodes cannot be assessed

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14
Q

N0

A

no regional lymph node metastasis

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15
Q

M0

A

no distant metastasis

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16
Q

M1

A

distant metastasis

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17
Q

Mitotic index

A

the percentage of actively dividing cells within a tumor

85%- fast growing tumor

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18
Q

Viral carcinogens examples

A

Eptein-Barr virus, hep B and hep C, HPV

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19
Q

Biggest CA risk factor

A

age (>60)

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20
Q

7 warning signs of CA

CAUTION

A
C- changes in bowel or bladder habits
A- A sore throat that does not heal
U- Unusual bleeding or discharge
T- Thickening or lump in the breast or elsewhere
I- Indigestion or difficulty swallowing
O- Obvious change in a wart or mole
N- Nagging cough or hoarseness
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21
Q

Cancer that invades the bone marrow causes what?

A

anemia, thrombocytopenia, and reduce production of healthy WBC’s

22
Q

Cancer that spreads to the liver causes what?

A

malnutrition and death

23
Q

Radiation tx

A

destroys cancer cells with minimal exposure to normal cells

local treatment

24
Q

Radiation dose

A

amount of radiation absorbed by the tissue

always less than exposure

25
Q

Teletherapy

A

radiation source is external to the PT

PT is not radioactive

26
Q

Brachytherapy

A

radiation in direct, continuous contact with the tumor

the patient emits radiation and is hazardous to others for 48 hours after

27
Q

Chemotherapy

A

major tx

has some selectivity for killing CA cells over normal cells

28
Q

Types of normal cells effected by chemotherapy

A

those that divide rapidly such as skin, hair, intestinal tissues, spermatocytes, and blood forming cells

29
Q

Nadir

A

the time when bone marrow activity and WBC counts are at their lowest level after chemo

30
Q

Frequency of chemotherapy administration

A

every 3-4 weeks

on average 4-12 times

31
Q

Extravasation

A

the major complication of IV infusion
drug leaks into the surrounding tissues
can cause severe tissue damage
Surgery may be needed

32
Q

Side effects of chemo

A
anemia
thrombocytopenia
neutropenia 
mucositis
changes in cognitive function
N/V
peripheral neuropathy
33
Q

Neutropenia

A

greatly increases risk for infection and can cause death

34
Q

Neutropenia tx

A

BMR’s (biologic response modifier) to stimulate bone marrow production

35
Q

BMR’s ex

A

neupogen, procrit/epogen, neumega

36
Q

Thrombocytopenia

A

increases risk for bleeding

<20K platelets may have spontaneous bleeding and need a transfusion

37
Q

Mucositis

A

open sores on mucous membrane
especially stomatitis
PT should drink 3L of H2O daily

38
Q

Hormonal manipulation

A

aimed at decreasing hormones to slow CA growth

39
Q

Tamoxifen

A

estrogen antagonist-agonist
used to tx breast CA
binds to estrogen so it is unavailable for cells

40
Q

Tamoxifen se

A
hot flashes and wt gain
increased hair growth
decreased breast tissue or gynnecomastia in men
sexual disfunction
increased risk of DVT
41
Q

Photodynamic therapy

A

Selective destruction of cancer cells through a chemical reaction triggered by different types of laser light
Dye is administered IV and collects in CA cells in 2-3 days

42
Q

Photodynamic therapy se

A

photosensitive for 12 weeks (sunblock will not prevent sunburn)
eye/skin pain

43
Q

Oncologic Emergencies

A
sepsis
disseminated intravascular coagulation (DIC)
SIADH
spinal cord compression
hypercalcemia
superior vena cava syndrome
44
Q

disseminated intravascular coagulation (DIC)

A

often caused by sepsis
seen in leukemia
clotting followed by bleeding

45
Q

disseminated intravascular coagulation (DIC) sx

A

pain, strokelike symptoms, dyspnea, tachycardia, oilguria, and tissue death

46
Q

SIADH sx and tx

A

hyponatremia, weakness, muscle cramps, fatigue, loss of appetite, seizures, coma
tx: Fluid restrictions

47
Q

Hypercalcemia

A

usually seen in bone CA

48
Q

Hypercalcemia sx and tx

A

Fatigue, N/V, constipation, polyuria, etc

tx: Increase hydration, calcitonin

49
Q

Superior vena cava syndrome

A

Occurs from compression of the SVC

50
Q

Superior vena cava syndrome sx

A

edema of the face especially around the eyes upon awakening, tightness of the shirt collar, edema in the arms and hands, dyspnea, erythema of the upper body, nose bleeds, ALOC