Chapter 20 Arthritis and Other Connective Tissue Diseases Flashcards
Rheumatic disease definition
any disease or condition involving the musculoskeletal system.
Arthritis definition
inflammation of one or more joints
Osteoarthritis
Noninflammatory arthritis Not systemic Not an autoimmune disease Most common type of arthritis Progressive loss of cartilage
Inflammatory arthritis types
Rheumatoid arthritis
Systemic lupus erythematosus
Osteoarthritis clinical manifestations
Heberden’s nodes
Bouchard’s nodes
Joint effusions
Atrophy of skeletal muscle
Osteoarthritis labs
erythrocyte sedimentation rate and C-reactive protein may be slightly elevated
Tests used to dx Osteoarthritis
MRI, CT, Radiograph, labs
Rheumatoid Arthritis
Connective tissue disease
Destructive to joints
Chronic, progressive, systemic inflammatory autoimmune disease
Rh factors attach synovium
Early RA sx
manifestations—joint stiffness, swelling, pain, fatigue, and generalized weakness and morning stiffness
Late RA sx
joints become progressively inflamed and painful
Syndromes associated with RA
Sjögren’s syndrome
Felty’s syndrome
Caplan’s syndrome
RA labs
assessment—rheumatoid factor, antinuclear antibody titer, erythrocyte sedimentation rate, serum complement, serum protein
RA diagnostic assessments
x-ray, CT, arthrocentesis, bone scan
RA drug therapy
Disease-modifying antirheumatics NSAIDs Biologic response modifiers Glucocorticoids Immunosuppressive agents
Lupus Erythematosus
Chronic, progressive, inflammatory connective tissue disorder
Autoimmune
Remissions and exacerbations
Often involves kidneys
