10 minute topic Cardiovascular medications Flashcards
Nitroglycerin use/function
stable angina
vasodilator
decreases O2 demand
Can be used in HF
Nitroglycerin use in variant angina
prevents or reduces coronary artery spasm and that provides more oxygen to the myocardium itself
Nitroglycerin cautions
use cautiously with antihypotensives due to risk of orthostatic hypotension
IV nitroglycerin
given to control angina that did not respond to other meds or to keep BP low
Nitroglycerin PT teaching
HA is common Orthostatic hypotension Flushing is common Reflex tachycardia will develop a tolerance (need to have a nitrate free period)
Nitroglycerin interactions with food
ETOH causes hypotension
Instructions for nitrate use
Chest pain → stop activity & rest →sublingual nitro x3, 5min apart, →unrelieved 911
Nitroglycerin storage
Glass container in a dark place, can’t get too warm so not in a pants packet
metoprolol tartrate (Lopressor) & atenolol (Tenomin) category
Beta blockers
metoprolol tartrate (Lopressor) action
antidysrhthmic (blocks conduction through SA and AV nodes) and antihyperstensive
Decreases heart rate and contractility therefore it decreases oxygen demand by the myocardium
Blocks renin release
metoprolol tartrate (Lopressor) nursing consideration
monitor bradycardia and hypotension
Use in caution with HF
Avoid use in PT’s with asthma due to bronchospasm
Can mask hpyoglycemic sx in DM
streptokinase (Streptase) alteplase (Activase), Reteplase (Retavase) category
thrombolytics
thrombolytics action
these medications dissolve clots that have already formed
thrombolytics used to tx what
treat MI (with MI best to give within 6 hours of infarct), DVT, massive pulmonary emboli and ischemic strokes
thrombolytics nursing considerations
do not use in active bleeding
monitor PT, aPTT, INR, fibrinogen levels, CBC
Monitor for allergic reaction (urticaria, itching, flushing)
ASA (salicylic acid), enteric coated is called (Ecotrin), clopidogrel (Plavix) category
Antiplatelet agents
Antiplatelet agents use
Acute MI- Primary
Prevention of reinfarction
Prevention of stroke
Acute coronary syndromes
Antiplatelet agents nursing considerations
can cause GI upset
use cautiously in PT’s with ulcers
Tinnitus is possible side effect or indication of toxicity
Antiplatelet agents teaching
take with food
report tinnitus
increased bleeding risk
Eptifibatide (Integrilin) category
Glycoprotein IIB/IIIA inhibitors
Glycoprotein IIB/IIIA inhibitors use
prevent the binding of fibrogen, in turn by blocking platelet aggregation. It is used in combination with ASA therapy
Glycoprotein IIB/IIIA inhibitors nursing consideration
can cause active bleeding, need to report s/sx of bleeding
Diuretics use
reduce preload
Loop diuretics
furosemide(Lasix) bumetanide (Bumex) – ↓Na reabsorption ↑K+ excretion
Thiazide diuretics
hydrocholorothiazide (Hydrodiuril)
K+ sparing diuretics
spironolactone (Aldactone)
in distal tubule prevent NA reabsorption in exchange for K+
watch for hyperkalemia
K+ outside normal ranges causes what
too low = muscle weakness, irregular pulse
too high = slow heart
IV lasix rate
no faster than 20 mg.min
Heparin category
anticoagulant
Unfractionated heparin
must be given IV
prevents clots from forming or becoming bigger
Warfarin (coumadin)
given PO
it must be given 3-5 days in concurrence with Heparin or Lovenox to get to a therapeutic levels
Anticoagulant nursing considerations
monitor platelets
monitor bleeding, PT & INR
Labs to monitor with heparin
aPTT for titration of dose, so based on what the PTT is the dose will be titrated to that
Antidote for heparin
protamine sulfate
made from salmon semen
Warfarin antidote
vitamin K
Who takes warfarin?
chronic Afib to < risk of clots being tossed
those with prosthetic heart valves
ACE inhibitors & ARBs function
afterload reducers, they help heart pump more easily by altering the resistance to contraction
enalapril (Vasoctec) captopril (Capoten) category
ACE inhibitor
losartan (Cozaar) candesartan (Atacand) category
ARB
ARB ending
sartan
ACE ending
pril
ACE and ARB contraindications
renal deficiency
ACE and ARB nursing considerations
monitor BP closest after 1st dose for hypotension
monitor for high K+
digoxin (Lanoxin), dopamine, dobutamine (Dobutrex) milrinone (Primacor) category
Inotropic Agents
Inotropic Agents function
Increase the force of myocardial contraction and improve cardiac output
Inotropic Agents used for what?
HF and also in patients who have dysrhythmias, primarily Afib
dopamine, dobutamine, milrinone administration
IV only
Will be in ICU, monitor ECG, BP and urine output
PO digoxin considerations
give at the same time daily
no antacids within 2 hours
regular dig and K+ levels
Signs of digoxin toxicity
fatigue, muscle weakness, anorexia, confusion, vision changes, halos around lights, problems with night vision
Interaction of digoxin and loop diuretics
increases the risk of digoxin induced dysrhythmias
Interaction of digoxin and ACE + ARB
increased risk of hyperkalemia and can decrease therapeutic actions of the digoxin
Verapamil hydrochloride (Calan) amlodipine (Norvasc) diltiazem (Cardizem) category
Calcium channel blocker
Verapamil hydrochloride (Calan) amlodipine (Norvasc) diltiazem (Cardizem) function
alter the movement of Ca+ ions through the cell membrane causing vasodilation and lower BP
Used for angina and dysrhythmias, primarily Afib, Atrial flutter and SVT
Calcium channel blocker cautions
HF and heart block, and bradycardia
If using Verapamil or Cardizem be careful when using digoxin or beta blockers
Calcium channel blocker education
can cause constipation
Bradycardia & AV block can occur
avoid grapefruit juice
atorvastatn (Lipitor), simvastatin (Zocor) lovastatin (Mevacor), Pravastatin sodium (Pravachol), Rosuvastatin (Crestor) category
Antilipemics - STATINs
Antilipemics - STATINs function
Lowers LDL levels by suppressing cholesterol synthesis in the liver and increases HDL
Antilipemics - STATINs cautions
PT’s with liver disease
Antilipemics - STATINs adverse effects
hepatotoxicity- so we need LFT’s
Myopathy- muscle aches and pain in peripheral extremities
Peripheral neuropathy -tingling in hands and feet