Chapter 16: Infectious Diseases Affecting the Skin- Part 1 Flashcards

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1
Q

Stratum corneum

A

25 cells thick, dead cells that have migrated from the deeper layers

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2
Q

Entire epidermis replaced every..

A

25-45 days

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3
Q

Keratin

A

Give cells the ability to withstand damage, abrasion and water penetration

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4
Q

Stratum basale

A

Several layers below the stratum corneum, attached to the dermis, source of cells that make up epidermis

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5
Q

Other protective characteristics of the skin and its defenses

A

Sebaceous (oil) glands
Antimicrobial peptides
Sweat
Lysozyme

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6
Q

How does sweat protect?

A

pH and flushing

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7
Q

How does sebum protect?

A

Microbes get stuck in it

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8
Q

Lysozyme

A

Specific to mucus membrane and eyes, attacks bacterial cell wall

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9
Q

What layer of the epidermis is the thickest?

A

Stratum corneum

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10
Q

Normal biota of the skin must be capable of…

A

Living in dry, salty conditions

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11
Q

Are a majority of the normal biota culturable?

A

No

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12
Q

Human microbiome project has shown that which genera are found on the skin?

A
Staphylococcus
Propionbacterium
Corynebacterium
Malassezia
Pseudomonas
Janthinobacterium
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13
Q

Maculopapular rash diseases

A

Flat to slightly raised colored bumps

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14
Q

Maculopapular rash diseases types

A
Measles 
Rubella
Fifth disease
Roseola
Scarlet fever
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15
Q

Fifth disease is caused by..

A

B19 parovirus

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16
Q

Roseola is caused by..

A

Human herpes virus

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17
Q

What does roseola do?

A

Changes color of skin

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18
Q

Scarlet fever is caused by..

A

Streptococcus pyogenes

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19
Q

Impetigo

A

Superficial bacterial infection, usually in children, near nose / mouth

20
Q

Cellulitis

A

Bacterial infection that involves dermis and subcutaneous level

21
Q

Rocky Mountain Spotted Fever

A

Caused by Rheketzia, spread by tick bite

22
Q

Vessicular or pustular rash diseases

A

Chickenpox, smallpox, HSV

23
Q

Conjunctivitis

A

Pink eye

24
Q

Keratitis

A

Severe eye infection that can lead to destruction of cornea

25
Q

Has there been a reduction in measles cases within the 20th century?

A

Yes because of vaccination programs

26
Q

Symptoms of measles

A
  • Begins with fever, runny nose, cough, red weepy eyes

- Fine rash appears within a few days

27
Q

Where does the fine rash of measles begin?

A

Appears first on forehead, then spreads to rest of body

28
Q

When do symptoms of measles generally disappear?

A

Within 1 week

29
Q

Many cases of measles are complicated with…

A

Secondary infections

30
Q

What are the most common secondary conditions of measles?

A

Pneumonia and earaches

31
Q

Less common complications of measles

A

Encephalitis and subacute sclerosis panencehalitis (SSPE)

32
Q

Measles is most contagious in what stage?

A

Red weepy eye stage

33
Q

Febrile

A

Fever

34
Q

Measles still kills about _____ people every year

A

700,000

35
Q

Measles causative agent

A

Rubeola virus

36
Q

Characteristics of rubeola virus

A

Pleomorphic, medium sized, enveloped

37
Q

The envelope of the rubeola virus contains..

A

Two different types of spike proteins

38
Q

What are the two spike proteins of the rubeola virus for?

A

One for viral attachment to host

One for fusion with host membrane

39
Q

Rubeola virus genome

A

Single-stranded RNA

40
Q

What family does the rubeola virus belong to?

A

Paramixoviridae

41
Q

Host (s) of measles

A

Humans are only natural host

42
Q

Measles virus (rubeola) is spread by..

A

Respiratory droplets

43
Q

Before routine immunization, what percent of the population was infected?

A

Over 99%

44
Q

Is measles still endemic in the US?

A

No

45
Q

What illnesses are next to be eradicated?

A

Measles

Polio

46
Q

Prevention of measles

A

Directed toward vaccination (usually given in conjunction with mumps, rubella, varicella vaccine, MMRV)

47
Q

Is there an antiviral treatment for rubeola infection?

A

No