Chapter 14 Disease and Epidemiology Flashcards
what is the definition of pathology?
study of disease
etiology definition?
study of cause of disease
pathogenesis defintion?
manner in which disease develops
infection definition?
invasion or colonization of the body by pathogen microbes
disease definition?
infection resulting in any structural/functional changes in health (fever/sore throat/malaise)
can you be infected without having a disease?
yes, you can be infected with pathogens, but have no outward signs that you’ve been infected = no disease
what is the human microbiome project?
finds the relationship between microbial communities on the body and human health
what is the normal microbiome?
any microbe living on and within the body that does NOT cause harm
At what age and how do people acquire their normal microbiome?
gain most of microbiome within first 3 years
within utero (from mother), food, people, pets, outside environment
how are our normal microbes beneficial to us?
- outcompete pathogens for nutrients (like within our gut/stomach)
- produces substances harmful to invading microbes (but harmless to us)
- affects pH and available oxygen (which keeps pathogens from growing)
define opportunistic pathogen
microbes that do not cause disease in their normal habitat but may do so in a different environment
What can allow opportunistic pathogens to cause disease?
Weakened immune system (from disease or previous infection)
Define the three forms of host-microbe symbiosis.
- commensalism
- mutualism
- parasitism
what is commensalism?
form of host-microbe symbiosis where one organism benefits, and the other is unaffected
what is mutualism?
form of host-microbe symbiosis where both organisms benefit
what is parasitism?
form of host-microbe symbiosis where one organism benefits at the expense of the other
what is transient microbiota?
microbes that may be present for only days, weeks, or months
where is one place that normal microbes can be found and how it helps us?
bacteria found within the lining of our stomach, help in digesting food
what is the purpose of Koch’s Postulates?
the process of determining which microbe is responsible for a disease
completely write out the four conditions of Koch’s postulates.
- The same pathogen must be present in every case of the disease.
- The pathogen must be isolated from the diseased host and grown in pure culture.
- The pathogen from the pure culture must cause the disease when it’s inoculated into a healthy, susceptible laboratory animal.
- The pathogen must be isolated from the inoculated animal and must be shown to be the original organism.
What are 4 important exceptions to Koch’s postulates?
- Some diseases caused by a variety of microbes
- Some pathogens can cause several disease conditions
- Some pathogens cause disease only in humans (would be unethical to test in humans)
- Some microbes have never been cultured
Know what theory from chapter 1 Koch’s work is related to.
Koch’s postulates were important to germ theory of disease
How is a symptom distinct from a sign?
- symptoms – are changes in body function FELT by patient that result from disease (pain, general unwell feeling)
- sign – are changes in body that can be MEASURED or observed as result from disease (fever)
What makes a communicable disease contagious?
diseases are spread from one host to another
define endemic disease
disease CONSTANTLY present in a population