Chapter 14 Flashcards
pathology
study of diseases
etiology
cause of a disease
pathogenesis
development of disease
infection
invasion or colonization of the body by pathogens
disease
abnormal state in which the body is not preforming normal functions
the human microbiome begins to established in the
utero
you get microorganisms acquired from
food, people, pets
human microbiome project
analyzes relationship between microbial communities on the body and human health
normal microbiota/flora
permanently colonize the host and do not cause disease under normal conditions
transient microbiota
may be present for days, weeks, or months and then disappear
distribution and composition of normal microbiota are determined by many factors, what are some of these factors
nutrients, physical and chemical factors, host defenses, mechanical factors
microbial antagonism (competitive exclusion)
is a competition between microbes
normal microbiota protect the host by
competing for nutrients
producing substances harmful to invading microbes
affecting pH and available oxygen
when the balance between normal microbiota and pathogenic is upset what can result
disease
the relationship between normal microbiota and host display what type of relationship
symbiosis
symbiosis
the realationship between normal microbiota and the host
commensalism symbiosis
one organism benefits, and the other is unaffected
Mutualism symbiosis
both organisms benefit
parasitism symbiosis
one organism benefits at the expense of the other
opportunistic pathogens
do not cause harm under normal conditions but if there is a change in immunity of health of the host these can cause disease
Kochs Postulates
1. the same __________ must be present in every case of the disease
2. the pathogen must be ________ from the diseased host and grown in pure culture
3. the pathogen from the pure culture must cause the _________ when its inoculated into a healthy susceptible lab animal
4. the pathogen must be isolated from the inoculated animal and must be shown to be the _________ ___________
pathogen, isolated, disease, original organism
Kochs postulates are used to prove the cause of an
infectious disease
some exceptions to kochs postulates
some pathogens can cause several disease conditions
some pathogens cause disease only in humans
some microbes have never been cultured
symptoms
changes in body function that are felt by the patient as a result of disease
signs
changes in a body that can be measured or observed as a result of disease
can symptoms be measured by observer
no, signs can be measured though
examples of signs
fever, lesions, edema
syndrome
specific group of signs and symptoms that accompany a disease
communicable disease
disease that is spread from one host to another
contagious disease
disease that are easily and rapidly spread from one host to another
noncommunicable disease
disease that is not spread from one host to another
incidence
number of people who develop a disease during a particular time period
incidence is the indicator of the
spread of the disease
prevalence
number of people who develop a disease at a specific time, regardless of when it first appeared
prevalence takes into account
new and old cases
prevalence is an indicator of
how seriously and how long a disease affects a population
sporadic disease
disease that occurs only occasionally
endemic disease
disease constantly present in a population
epidemic disease
disease acquired by many people in a given area in a short time
pandemic disease
worldwide epidemic
acute disease
symptoms develop rapidly but the disease lasts only a short time
chronic disease
symptoms develop slowly
subacute disease
intermediate between acute and chronic
latent disease
causative agent is inactive for a time but then activates and produces symptoms
herd immunity
immunity in most of a population
where there is herd immunity outbreaks are limited to
sporadic cases because there is not enough susceptible individuals to support the spread to epidemic proportions
local infections
pathogens are limited to a small area of the body
systemic (generalized) infection
an infection throughout the body