Ch. 9 Blood, Lymphatic, and Immune Systems Flashcards
Blood functions:
TRANSPORT/PROVIDE/CLOT
transport O2/CO2
provide cells that defend against disease
protects body from loss of blood by clotting.
Lymphatic system function:
CELL. COMM./DRAIN/PROVIDE
cellular communication by delivering nutrients, hormones, and other products to cells
remove waste when draining tissue fluid back to vascular system
provides immune system cells to defend body against disease
Immune system function:
defend body against disease by preventing unwanted substances from entering body (lymphatic cells identify/destroy pathogens and protect against future encounters with them)
antibody
Protective protein produced by B lymphocytes in response to presence of antigen
antigen
Foreign substance recognized as harmful to host
stimulates formation of antibodies in immunocompetent individual
bile pigment
Substance derived from breakdown of hemoglobin and excreted by the liver
cytokine
Chemical substance produced by cells that initiates, inhibits, increases, or decreases activity in other cells
dendritic cell
Specialized monocyte that displays antigens on its cell surface and presents them to components of immune system
dendr-
tree
-itic
pertaining to
immunocompetent
Possessing ability to develop an immune response
natural killer (NK) cells
Specialized lymphocytes
destroy virally infected&tumor cells by releasing chemicals that disrupt their cell membranes, causing their intercellular fluid to leak out
Blood is ______ _____ composed of:
(connective tissue)
plasma (liquid medium) suspending solid components
Solid components of blood:
- red blood cells (erythrocytes)
- white blood cells (leukocytes)
- platelets (thrombocytes)
In adults, blood cells form:
in bone marrow of skull, ribs, sternum, vertebrae, pelvis, and ends of the long bones of the arms and legs.
Stem cells in the bone marrow give rise to:
embryonic (blastic) forms of all blood cell types.
Which cells migrate to lymphatic system for maturation and specialization during their embryonic stage?
monocytes
lymphocytes
Where do most embryonic cells complete their development?
Bone marrow
When do blood cells enter the circulatory system?
once they are mature
term for development of blood cells into their mature forms
hematopoiesis or hemopoiesis
erythrocytes
red blood cells (RBCs)
transport O2 and CO2
most numerous circulating blood cells
erythropoiesis
RBC development
decrease size/extrude nuclei right before reaching maturity
develop hemoglobin
shaped like biconcave disks
hemoglobin (Hb, Hgb)
iron-containing compound
gives RBCs red color
carries O2 to body tissues, exchanges for CO2
Life span and death of RBCs
after ~120 days they rupture, releasing hemoglobin and cell fragments
Hemoglobin breaks down into hemosiderin (iron compound) and several bile pigments
most hemosiderin returns to bone marrow for use in forming new blood cells
liver eventually excretes bile pigments.
leukocytes
white blood cells (WBCs)
protect against invasion by pathogens and foreign substances
remove debris from injured tissue
aid in the healing process
What function makes leukocytes crucial in bodies defense against disease?
phagocytosis (ability to ingest and destroy bacteria and other foreign particles
What other function makes WBCs unique?
diapedesis, the ability to migrate through endothelial walls of capillaries and venules and enter tissue spaces.
2 major types of leukocytes:
granuloctyes - granules in cytoplasm
agranulocytes - absence of granules in cytoplasm
(when observed microscopically)
3 types of granulocytic leukocytes:
neutrophils
eosinophils
basophils
How are granulocytic leukocytes classified?
the staining reaction of their cytoplasmic granules during the preparation of blood smears
polymorphonuclear leukocytes (PMNLs, polys)
the appearance of multiple nuclei in mature granulocytes (because they are so deeply lobed, especially neutrophils)
Another name for agranulocytes :
mononuclear lymphocytes (MNLs)
5 major leukocytes:
Granulocytes:
neutrophil
eosinophil
basophil
Agranulocytes
lymphocytes
monocytes
Neutrophil function:
- First cell to arrive at a site of injury
- Provides nonspecific protection by phagocytosis
- Dies as a result of phagocytosis
Eosinophil function:
- Combats multicellular parasites (worm infestations)
* Controls mechanisms associated with allergies
Basophil function:
• Initiates inflammation
Lymphocytes function:
• Provides acquired (specific) immunity
Monocytes function:
- Performs mildly phagocytic function
* Becomes a macrophage when it enters tissues and functions in immunity
thrombocytes
Platelets
smallest elements in blood
not true cells but cell fragments
initiate blood clotting when they encounter vessel walls that have been injured or traumatized
thromboplastin
substance that initiates clot formation
released by clotting factors in platelets and injured tissue
fibrinogen
a soluble blood protein
becomes insoluble and forms fibrin strands that act as a net, entrapping blood cells to form blood clot
hemostasis
when blood clot impedes the flow of blood into the surrounding tissues as a response to injury
Without blood cells, plasma appears:
as a thin, almost colorless fluid
Plasma is composed of:
92% water albumins globulins fibrinogen (plasma proteins) clotting factors gases nutrients salts hormones
What makes cellular communication possible throughout the body?
The exchange of products between capillaries and surrounding cells/structures.
Blood serum:
product of blood plasma formed when fibrinogen and clotting factors are removed from blood plasma.
Blood type A
41% population
antigen A
antibody B
Blood type B
10% population
antigen B
antibody A
Blood type AB
4% population
antigen AB
antibody NONE
Blood Type O
45% population
antigen NONE
antibody AB
Blood types are medically important in:
transfusions, transplants, and maternal-fetal incompatibilities.
The lymphatic system consists:
LYMPH (a fluid that contains lymphocytes and monocytes)
LYMPH VESSELS (network of transporting vessels)
NODES
SPLEEN
THYMUS
TONSILS
Functions of lymphatic system:
- MAINTAIN FLUID BALANCE of body by draining interstitial fluid from tissue spaces and returning it to the blood
- TRANSPORT LIPIDS AWAY from digestive organs for use by body tissues
- FILTER/REMOVE UNWANTED or infectious products in lymph nodes
Lymph vessels begin as:
closed-ended capillaries in tissue spaces
Lymph vessels terminate at:
right lymphatic duct and thoracic duct in chest cavity
interstitial fluid
aka tissue fluid
plasma in tissue
resembles plasma but contains slightly less protein
carries needed products to tissue cells while removing their wastes
As interstitial fluid moves through tissues, it collects
cellular debris, bacteria, and particulate matter.
interstitial fluid leaves tissue through:
surrounding venules to become plasma
lymph capillaries to become lymph.
Lymph passes into larger and larger vessels on its return trip to the bloodstream. Before it reaches its final destination, it first enters:
lymph nodes through afferent vessels
What happens in lymph nodes?
macrophages phagocytize bacteria and other harmful material
T cells and B cells exert their protective influence
Why do lymph nodes enlarge and become tender?
the large number of bacteria entering node
the powerful destruction by T cells and B cells
When and how does lymph leave lymph node?
After filtered
through efferent vessel
right lymphatic duct
join with lymph vessels from right chest/arm
drains into right subclavian vein
thoracic duct
joins with lymph from rest of body
drains into left subclavian vein
Lymph is redeposited into:
the circulating blood and becomes plasma.
How is a spleen like a lymph node?
it acts as filter by removing cellular debris, bacteria, parasites, and other infectious agents
What does a spleen do that lymph nodes do not?
destroys old RBCs
stores healthy blood cells
thymus
located in mediastinum
partially controls immune system by transforming certain lymphocytes into T cells
tonsils
masses of lymphatic tissue located in the pharynx
act as filters to protect upper respiratory structures from invasion by pathogens.
two major immune defenses:
innate immunity
acquired immunity
innate immunity:
present from birth
nonspecific
stops spread of pathogens
has 2 types of barriers to keep pathogens out (1st & 2nd line)
first-line barriers
keep pathogens from entering body (skin and mucous membranes, tears, saliva, and gastric secretions)
second-line barriers
stop spread of pathogens once they have gained entry, including phagocytic cells, natural killer cells, and inflammation
Acquired immunity
AKA adaptive immunity develops after birth specific lifelong monitoring system monocytes and lymphocytes produces unique cells and processes that destroy particular antigen
Specific
system produces “custom made” method to destroying antigen
nonspecific
system does not differentiate the various types of pathogens and is always ready to defend the body, no matter the type or nature of the pathogen
macrophages (origin)
monocytes that enter tissue spaces from vascular system and become highly phagocytic
macrophage (function)
ingests pathogens and other harmful substances
processes, preserves and DISPLAYS their unique antigenic properties on surface which alerts immune system to presence of pathogen
antigen-presenting cell (APC)
macrophage when it is displaying antigenic properties
wait for encounter/response from capable immune cell
Dendritic cells
specialized macrophages that also have the ability to act as APCs
Two types of lymphocytes
B cells (B lymphocytes) T cells (T lymphocytes)
Lymphocytes:
active cells of the acquired immune response
B cells develop this immunity type:
humoral or antibody
T cells develop this immunity type:
cellular
Cytokines
hormonelike chemicals
act as messengers between the T and B cell defense systems
regulate intensity/duration of responses
provide cell-to-cell communication
active immunity
long-lasting immunity
memory B and T cells “recall and repeat” destruction/disposal of antigen in a more rapid and effective way than during 1st exposure
Complete Anatomy Review
Lymphatic System pg 276
The main functions of the blood, lymphatic, and immune systems are:
provide a way to transport and exchange products throughout the body
protect and repair cells that are damaged by disease or trauma.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Cardiovascular
- Blood delivers oxygen needed for contraction of heart.
- Lymphatic system returns interstitial fluid to vascular system to maintain blood volume.
- Immune system protects against infections.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Digestive
- Blood transports products of digestion to nourish body cells.
- Immune system provides surveillance mechanisms to detect/destroy cancer cells in digestive tract.
- The acidic environment of the stomach helps control pathogens in the digestive tract.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Endocrine
- Blood and lymphatic systems transport hormones to target organs.
- Immune system protects against infection in endocrine glands.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Female Reproductive
- Blood, lymphatic, and immune systems transport nourishing and defensive products across placental barrier for developing fetus.
- The immune system provides specific defense against pathogens that enter the body through reproductive tract.
- The immune system supplies antibodies for breast milk that protect the baby until its immune system is established.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Integumentary
- Blood provides leukocytes, especially neutrophils when injury occurs
- The lymphatic system supplies antibodies to dermis for defense against pathogens.
- Blood in skin helps maintain temperature homeostasis.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Male Reproductive
CANCER/HORMONES/FLUID BALANCE
• Immune system provides surveillance against cancer cells.
- Blood delivers hormones and other essential products for male fertility.
- Lymph maintains fluid balance in male reproductive organs
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Musculoskeletal
ACID/CALCIUM/FLUID/REPAIR
• Blood removes lactic acid that accumulates in muscles during strenuous exercise.
• Blood transports calcium to bones for strength and healing.
• The lymphatic system maintains interstitial fluid balance in muscle tissue.
• The immune system aids in the repair of muscle tissue following trauma.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Nervous
INJURY/CROSS/FLUID
• The immune system responds to nervous stimuli to identify injury or infection sites and initiate tissue defense and repair.
- Plasma and lymph provide the media in which nervous stimuli cross from one neuron to another.
- The lymphatic system removes excess interstitial fluid from tissues surrounding nerves.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Respiratory
- Red blood cells transport respiratory gases to and from the lungs.
- The tonsils harbor immune cells to combat pathogens that enter through the nose and mouth.
Functional Relationship Between the Blood, Lymphatic, and Immune systems and
Urinary
- Blood transports waste products, especially urea, to the kidneys for removal via the production of urine.
- Blood in peritubular capillaries reabsorbs essential products that have been filtered by the nephron.
aden/o
gland
aden/o/pathy
disease of a gland
agglutin/o
clumping, gluing
-ation
process (of)
agglutin/ation
process of clumping/gluing
blast/o
embryonic cell
erythr/o/blast/osis
abnormal increase of red embryonic cells
-osis when referring to blood cells
increase
chrom/o
color
hypo-
under, below, deficient
hypo/chrom/ic
pertaining to deficient color
erythr/o
red
erythr/o/cyte
red blood cell
granul/o
granule
granul/o/cyte
cell of granule
hem/o
blood
hemat/o
blood
blood
hem/o
hemat/o
hem/o/phobia
fear of blood
hemat/oma
tumor of blood
immun/o
immune, immunity, safe
immun/o/logy
study of the immune system
leuk/o
white
leuk/emia
blood condition of white
lymph/o
lymph
-oid
resembling
lymph/oid
resembling lymph
lymphaden/o
lymph gland (node)
lymphaden/o/pathy
disease of the lymph node
lymphangi/o
lymph vessel
lymphangi/oma
tumor of lymph vessel
morph/o
form, shape, structure
morph/o/logy
study of form, shape, structure
myel/o
bone marrow; spinal cord
gen
forming, producing, origin
myel/o/gen/ic
pertaining to bone marrow/spinal cord forming/producing/origin
nucle/o
nucleus
mono-
one
mono/nucle/ar
pertaining to one nucleus
phag/o
swallowing/ eating
phag/o/cyte
cell of swallowing/eating
poikil/o
varied, irregular
poikil/o/cyte
cell of irregular
ser/o
serum
ser/o/logy
study of serum
sider/o
iron
-penia
decrease, deficiency
sider/o/penia
decrease/deficiency of iron
splen/o
spleen
splen/o/megaly
enlargement of the spleen
thromb/o
blood clot
thromb/osis
abnormal increase of blood clot
thym/o
thymus gland
thym/o/pathy
disease of the thymus gland
-blast
embryonic cell
hem/o/cyt/o/blast
embryonic cell of blood and cell
-globin
protein
hem/o/globin
protein of blood
-penia
decrease; deficiency
monocyt/o
monocyte
monocyt/o/penia
decrease/deficiency of monocyte
-phil
attraction for
neutr/o
neutral; neither
neutr/o/phil
attraction for neutral/neither
-phylaxis
protection
ana-
against; up; back
ana/phylaxis
protection against
-poiesis
formation, production
hem/o/poiesis
formation/production of blood
-stasis
standing still
hem/o/stasis
standing still of blood
aniso-
unequal, dissimilar
aniso/cyt/osis
abnormal increase of unequal/dissimilar cell
Complete Learning Activity 9-1
pg 294
Complete Learning Activity 9-2
pg 295
-penia
decrease
pertaining to small (red blood) cells
microcytic
destruction of blood
hemolysis
pertaining to a nucleus
nuclear
resembling a gland
adenoid
formation (production) of blood
hemopoiesis
abnormal increase in erythrocytes
erythrocytosis
Lymphatic disorders are commonly associated with
edema and lymphadenopathy
Anemias, leukemias, and coagulation disorders typically share common signs and symptoms that include
paleness, weakness, shortness of breath, and heart palpitations.
hypersensitivities
abnormally heightened immune responses
immunodeficiencies, or immune deficiencies
depressed immune responses
autoimmunity
responses where the immune system fails to recognize its own tissue
Immune disorders
hypersensitivities
immunodeficiencies
autoimmunity
Hematology
is the branch of medicine that studies blood cells, blood-clotting mechanisms, bone marrow, and lymph nodes.
hematologist
physicians who specialize in hematology
Allergy and Immunology
branch of medicine concerning immune disorders (asthma and anaphylaxis), adverse reactions to drugs, autoimmune diseases, organ transplantations, and malignancies of immune system.
What are physicians who specialize in Allergy and Immunology called?
allergists and immunologists
erythropenia, erythrocytopenia
aka Anemia
deficiency of erythrocytes or hemoglobin in RBCs (hypochromia)
not a disease but a symptom of other illnesses
hypochromia
deficiency in amount of hemoglobin in RBCs
Sickle Cell Anemia
- primarily affects African descendants (who inherit trait from both parents)
- caused by hemoglobinopathy
- cells are fragile, easily hemolyze, and have difficulty passing through capillaries
- causes sickle cell crisis
hemoglobinopathy
defective hemoglobin molecule that causes RBCs to assume bizarre shapes, commonly resembling a crescent, or sickle, when oxygen levels are low
hemolyze
breaking apart of blood cells
sickle cell crisis
tissue distal to cell blockage undergoes ischemia, resulting in severe pain that can last from several hours to several days
Treatment for sickle cell anemia is designed to control or limit the number of crises
Aplastic (hypoplastic) anemia
Serious
associated with bone marrow failure
causes erythropenia, leukopenia, and thrombocytopenia
caused by autoimmune disorders, chemotherapy, radiation therapy, and exposure to certain cytotoxic agents
Folic-acid deficiency anemia
Caused by insufficient folic acid intake resulting from poor diet, impaired absorption, prolonged drug therapy, or increased requirements (pregnancy or rapid growth as seen in children)
Hemolytic (as a disorder)
Destruction of RBCs
causes jaundice
from inherited immune and blood (sickle cell anemia) disorders, medications, and incompatible transfusions
Iron-deficiency anemia
Lack of sufficient iron in RBCs
Caused by a greater demand for stored iron than can be supplied, usually as a result of inadequate dietary iron intake or malabsorption of iron
Pernicious anemia (PA)
Chronic, progressive ages 50+
lack of vitamin B12
result of inability to absorb B12
Sickle cell anemia
Inherited anemia that causes RBCs to become crescent- or sickle-shaped when oxygen levels are low
Caused by a defect in the gene responsible for hemoglobin synthesis
An allergy is:
acquired abnormal immune response
requires initial exposure (sensitization)
subsequent exposures produce increasing allergic reactions that cause broad range of inflammatory changes
indurated
hardened
Allergy shots (immunotherapy, biotherapy) help with:
pollens, pet dander, molds, dust mites, and venom (bee stings)
BUT NOT FOOD
reducing or even eliminating the symptoms associated with the allergy.
Immunotherapy involves:
repeated, gradually increasing in concentration, injections of allergen
body forms new antibodies
autoantigens
antigens found on cells and tissues
autoimmune disease produces:
autoantibodies - an abnormal response directed at the autoantigens of the body until cells are destroyed
multisystemic
affecting many organs and systems
Autoimmune diseases include:
rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis, myasthenia gravis, vasculitis, and various thyroid disorders
Most autoimmune diseases have:
periods of flare-ups (exacerbations) and latencies (remissions).
The major types of blood cancers include multiple myelomas that affect:
a single type of bone marrow cell
lymphomas in lymphatic system
leukemias that affect blood and bone marrow.
Leukemia
oncological disorder of blood and blood-forming organs
characterized by an overgrowth (proliferation) of blood cells.
body replaces healthy blood and bone marrow cells with immature, nonfunctional cells, leading to anemias, infections, and bleeding disorders.
Leukemia is the most common cancer in:
children, youth, and young adults
Types of leukemia:
granulocytic (myelogenous)
lymphocytic
These can be classified as:
acute
chronic
Acute leukemia:
disease has a sudden onset and blood cells are highly embryonic (blastic) with few mature forms. Severe anemia, infections, and bleeding disorders appear early in the disease. This form of leukemia is life-threatening.
Chronic Leukemia
signs and symptoms are slow to develop because there are usually enough mature cells to carry on the functions of the various cell types. As the chronic form progresses, signs and symptoms develop.
acquired immunodeficiency syndrome (AIDS)
Infectious disease
causes HIV
destroys the CD4 (helper T) cells
makes host susceptible to opportunistic infections
coagulation disorders
Any disruption or impairment in the ability to form blood clots or control bleeding
disseminated intravascular coagulation (DIC)
Abnormal blood clotting in small vessels throughout the body that cuts off the supply of oxygen to distal tissues, resulting in damage to body organs
hemophilia
Congenital hereditary disorder characterized by a deficiency in clotting factor VIII (hemophilia A) or clotting factor IX (hemophilia B), resulting in prolonged bleeding; also called bleeder’s disease
thrombocytopenia
Abnormal decrease in platelets caused by low production of platelets or their increased destruction in the blood vessels, spleen, or liver
graft rejection
Process in which a recipient’s immune system identifies the transplanted graft as “foreign” and attacks or destroys it
graft-versus-host disease (GVHD)
Complication that occurs following a stem cell or bone marrow transplant in which the transplant produces antibodies against the recipient’s organs, commonly severely enough to cause death
hemoglobinopathy
Any disorder caused by abnormalities in the hemoglobin molecule
infectious mononucleosis
Acute infectious disease caused by the Epstein-Barr virus (EBV) that primarily affects young adults and children and causes fatigue, malaise, sore throat, and lymphadenopathy of the neck or armpits; also called mono and kissing disease
Kaposi sarcoma (KS)
Cancer caused by the human herpes virus 8 (HHV-8) that mainly affects the skin and mucous membranes but may also cause extensive visceral organ involvement; also called malignant neoplasm of soft tissue
lymphedema
Swelling, primarily in a single arm or leg, resulting from an accumulation of lymph within tissues caused by obstruction or disease in the lymph vessels
lymphoma
Any malignancy involving lymphocytes (B cells, T cells, or both) that commonly affects lymph nodes and other lymphatic tissue
Hodgkin (HL)
Malignancy of B cells that occurs in lymph nodes of the neck or chest and may spread to nearby lymph nodes and the spleen and sometimes to the bone marrow; also called classical Hodgkin lymphoma, Hodgkin disease
non-Hodgkin (NHL)
Any malignancy of B cells, T cells, or NK cells that does not involve Reed-Sternberg cells
multiple myeloma
Malignancy of the bone marrow that affects plasma cells, leading to proliferation of abnormal antibodies, destruction of healthy bone marrow cells, and weakening of bone tissue
sepsis
Presence of bacteria or their toxins in the blood; also called septicemia or blood poisoning
systemic lupus erythematosus (SLE)
Widespread autoimmune disease
affects the skin, brain, kidneys, and joints
causes chronic inflammation
aka discoid lupus (limited to skin)
thrombocythemia
Overproduction of platelets, leading to thrombosis or bleeding disorders as a result of platelet malformations
Complete Learning Activity 9-3
pg 296
antinuclear antibody (ANA)
Test that identifies the antibodies that attack the nucleus of the individual’s own body cells (autoantibodies)
blood culture
Test to determine the presence of pathogens in the bloodstream
complete blood count (CBC)
Series of tests that includes hemoglobin, hematocrit, red and white blood cell counts, platelet count, and differential (diff) count; also called hemogram
monospot
Nonspecific rapid serological test for the presence of the heterophile antibody, which develops several days after infection by Epstein-Barr virus, the organism that causes infectious mononucleosis
partial thromboplastin time (PTT)
Screening test for deficiencies in clotting factors by measuring the length of time it takes blood to clot; also called activated partial thromboplastin time (APTT)
prothrombin time (PT)
Test used to detect and diagnose bleeding disorders or excessive clotting disorders; also called pro time
bone marrow magnetic resonance imaging (MRI)
Highly sensitive imaging procedure that detects lesions and changes in bone tissue and bone marrow, especially in diagnosing multiple myeloma
lymphangiography
Visualization of lymph channels and lymph nodes using a contrast medium to determine blockages or other pathologies of the lymphatic system
lymphoscintigraphy
Introduction of a radioactive tracer into the lymph channels to determine lymph flow, identify obstructions, and locate the sentinel node
bone marrow aspiration
Removal of bone marrow (usually from the pelvis) for microscopic examination using a thin aspirating needle (See Fig. 9-11.)
bone marrow transplant (BMT)
Infusion of healthy bone marrow stem cells after destroying the diseased bone marrow by chemotherapy, radiation therapy, or both and commonly used to treat leukemia, aplastic anemia, and certain cancers; also called stem cell transplant
lymphadenectomy
Removal of lymph nodes, especially in surgical procedures undertaken to remove malignant tissue, in an effort to control the spread of cancer
sentinel node excision
Removal of the first node (sentinel node) that receives drainage from cancer-containing areas and the one most likely to contain malignant cells
immunotherapy
Any form of treatment that alters, enhances, stimulates, or restores the body’s own natural immune mechanisms to treat diseases; also called biological therapy
immunoglobulin (IG) therapy
Treatment using antibody mixtures, administered via intravenous, subcutaneous, or intramuscular routes
plasmapheresis
Dialysis procedure that removes and discards the patient’s plasma containing the autoantibodies responsible for tissue destruction in autoimmunity and returns the blood cells to the patient suspended in the plasma of a donor
transfusion
Infusion of blood or blood products from one person (donor) to another (recipient)
anticoagulants
Prevent blood clot formation by inactivating one or more clotting factors or inhibiting their synthesis
antifibrinolytics
Neutralize fibrinolytic chemicals in the mucous membranes of the mouth, nose, and urinary tract to prevent the breakdown of blood clots
antimicrobials
Destroy bacteria, fungi, and protozoa, depending on the particular drug, generally by interfering with the functions of the cell membrane or the reproductive cycle
antiretrovirals
Prevent replication of viruses within host cells
immunosuppressants
Decrease inflammation by suppressing the body’s natural immune response
thrombolytics
Dissolve blood clots by destroying their fibrin strands
AB, Ab, ab
antibody, abortion
ANA
antinuclear antibody
APC
antigen-presenting cell
APTT
activated partial thromboplastin time
BMT
bone marrow transplant
DIC
disseminated intravascular coagulation
diff
differential count (white blood cells)
EBV
Epstein-Barr virus
GVHD
graft-versus-host disease
HHV-8
human herpes virus 8
HIV
human immunodeficiency virus
HL
Hodgkin lymphoma
Ig
immunoglobulin
IVIG
intravenous immunoglobulin
KS
Kaposi sarcoma
MNL
mononuclear leukocytes
NHL
non-Hodgkin lymphoma
NK cell
natural killer cell
PA
pernicious anemia
PCP
Pneumocystis pneumonia; primary care physician
PMN
polymorphonuclear
PMNL, poly
polymorphonuclear leukocyte
PT
prothrombin time, physical therapy
PTT
partial thromboplastin time
SLE
systemic lupus erythematosus
Complete Learning Activity 9-4
pg 297