Ch 32 Thoracolumbar Vertebral column Flashcards

1
Q

TL IVD anatomy
AF
NP
Cartilage

A
  1. AF: concentric lamellae of collagen. offers biomech support and all multidurectional movement
  2. nucleus pulposus: remnant from notocord+ chrondrocyte like cells. hydrated, contains glycoaminoglycans (chondroiton, keratan) + Type IV collagen
  3. cartilage ends provide nutrients

longitissimus lumbrum (T11-L7) attaches accessory process
spinal n/vessels lie ventral and cranial to tendon
accessory process ~ level with ventral canal

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2
Q

What ligaments help to provide stability to the vertebral column?

A

Three long ligaments:
- Dorsal and ventral longitudinal ligaments
- Supraspinous ligament

Three short ligaments:
- interspinous
- intertransverse
- yellow ligaments

Intercapital ligaments (T2-T11)

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3
Q

spinal biomechnics
what forces does IVD resist? body? joint?
passive stability?
which sites ost common?

A
  • IVD provides majority of biomech stability, espicially for rotational and bending forces
  • joint: all forces
  • vertebral body: butress
  • passive: zygopophyseal joint, muscle tendons, IVD, ligaments
  • intercapital lig prob wh reduce disc protusion cranial to T11
  • disruption of IVD and articular joint alters biomechnics, worsened by double hemilam and lareh breed.
  • ## 50% IVDD @ T12/13 and T13/L1
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4
Q

Surgery IVDD
indications
timing (4)
aims

A

for decompression in apporptiate cases (based on neurolocalisation and predicted pathology)
folowing aporoptiate imaging for sxp planning
validated nuero score allow for improtant prognostic evluation (disucss order of loss…)

timing of sx: may mitigate ongoing injury due to compression, however this is contraversial and conflicting evidence in litaerature
1. acute, rapid and severe may benefit asap (bagley 2005)
2. increased PMM rate if delay (casel 2019)
3. no benefit within 24hr (upchurch 2020)
4. 5% may benefit from progression (Martin 2020)

aims: minimase bone removal to reduce instability

intuitive sooner rather than later

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5
Q

What muscles are encountered in a dorsal approach to the cranial thoracic spine (T1-T5) which are not encountered more caudally?

A

Trapezius
Rhomboideus
Splenius (cranially)
Serratus dorsalis (caudally)

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6
Q

Where does the nuchal ligament attach?

A

Spinous processes of T1 and T2

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7
Q

What are the main epaxial muscles encounted on a dorsal approach to the TL spine?

A

Multifidus > attached to articular process
Longissimus lumborum > attached to assessory process

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8
Q

What epaxial muscles are encountered on a lateral approach to the TL spine?

A

Serratus dorsalis caudalis
Longissimus lumborum
iliocostalis lumborum

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9
Q

Which muscles are seperated to allow a dorsolateral approach to the TL spine?

A

Multifidus and longissimus lumborum

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10
Q

What are the anatomic landmarks of a hemilam window?
What parts of the vertebral canal does it allow access to?

A

Landmarks:
- Ventral accessory process
- Base of spinous process
- Base of articular processes cranially and caudally

Access to ventral, dorsal and lateral canal

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11
Q

What is a pediculectomy and mini-hemilam?

use xsectional imaging to dictate approptiate laminectomy sx

A

Pediculectomy - Removes the pedicle over the body of 1 vertebra, leaving the zygapophyseal joint intact

Mini-hemilam - combined pediculectomy over contingous vertebrae

Faster and pediculectomy avoids the spinal nerve, artery and vein. Decreased exposure
possibly increased risk of disc left behind (huska 2014)

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12
Q

endoscopic assissted

druid 2019

A

MI, thus redcued soft tissue damage
equal/preferred in humans (reduced haemorrhage, faster, reduce complciations, better reovery)

cadaver study in canine

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13
Q

What are the three forms for dorsal laminectomy?

alternative to bilateral hemi

A

Funkquist A - Removal of spinous process, laminae, articular processes and approx half of the dorsal portion of the pedicles

Funkquist B - Leaves the articular processes and pedicles intact

Modified dorsal laminectomy - Removal of spinous process, laminae and caudal articular rpocesses are removed. Medial aspect of pedicles can be undercut to enhance exposure

dorsal, lateral access

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14
Q

What is the accuracy of radigraphs to determine the site of the primary IVDH?

no infor re cord compression

A

51-61%

vacuum sign specific

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15
Q

What is the sensitivity of myelography in determining the primary site and lateralisation of IVDH?

A

Site: 74 - 98%
Lateralisation: 55-100%

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16
Q

What prognostic factors can be determined from a myelogram?

A

Length of intramedullary pattern / length L2 vert ratio on a lateral view:
- Over 5 = 26% chance of recovery
- Less than 5 = 66% chance recovery

Intraparenchymal spinal cord contrast medium - seen in 6/7 dogs with myelomalacia in one study

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17
Q

What is the reported rate of posy-myelographic seizures? What are some risk factors

myelopathy, apnea, arrythmia, menigitis, bleed, death

A

10-21.4%
Risk factors include cisternal myelogram and large body size

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18
Q

What is the sensitivty of non-contrast CT for detecting the site and side of IVDH?

A

Site: 84-100%
Side: 79-94%

MRI has significantly higher sensitivity for site (87% vs79%

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19
Q

MRI vs CT

A

CT allow localisation and planning for majority of cases
> inc sensitivity with typical breed
> <10% require other image (emery 2018)
> myelogram increase sens/sepc
> if not IVDD, then difficult to deterimine dz
> MRI outperforms CT by most measrable charactersistics

MRI pros: see non-mineralised and if severe SCI, provide prognosis
> inc, contrast res thus ST suprerior
> disc ID (protusion, extrusion, ANNPE/HNPE

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20
Q

MRI findings

A
  • Hypointense on T1W and T2W
  • Non-degenerative disc can be isointense on T1W and hyperintense on T2W
  • loss of CSF and fat signal
  • contrast can intensify disc signal

100% seinsitive for location/site
superior to detect non-IVDD

T2W hyperintensity >3x L2 length only 20% recvoer VMF (levine 2009)

degree of compression not associated with outcome (penning 2006)

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21
Q

What sequences can be used on MRI to help identify an inconspicuous IVDH?

A
  1. T2* can help to identify haemorrhage
  2. STIR and FLAIR helpful to identify low volume disc extrusion
  3. ultrafast, heavily T2W sequence has appearance of a myelogram
  4. Disc material may enhance with gadolinium contrast
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22
Q

CT findings

A
  • loss of epidural fat opacity
  • cord compression
  • mineral density within cord
  • hyperattenuation = haemorrhage, disc
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23
Q

Tretatment

most studies restrospective, thus limitations > not randomised, diff neuro grading, poor follow up etc
provide useful info, but must be cautious with interpretation

A
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24
Q

What is the reported success rate of conservative management with IVDH?

A

82 - 88% ambulatory
43 - 51% non-ambulatory

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25
medical stratagies (3) ambulatory vs non
-rest allow AF to heal/scar -pain relief and antiinflamm physio to improve muscle mass studies report good outcomes for ambulatory dogs, difficutl to compare outcomes due to different medical tx levine 2007 > 80% ambulatory > 50% recover with no relapse > 15-20% Tx fail > 30% recurrence > nsaid beneficial, CCS equivolcol in general, for non-ambul: - longer reocvery and reduce return to functino when compared to Sx - no DPP, 7% recovery (davies 1983) - no new advancements in SCI mgmt with evidence-based imrpvoment
26
What is a lateral corpectomy? Success of decompression? Risks?
Creation of a “slot” in the vertebral body, 1/4 the length of the vertebrae 90% successful decompression, deeper slots more successful decompression Risks: Possible instability and risk of fracture/subluxation
27
What are the improvement rates after corpectomy?
18.7% immediate impovement 52.8% improvement at discharge 64.2% improvement 4 weeks 91.4% ambulatory at 6 months, 74.5% having a normal gait
28
durotomy A randomized trial comparing durotomy and standard decompression surgery alone would be ideal but problematic in practice. | olby ACVIM consensus
TIMING DPN: current literature does not generally demonstrate improved neurologic outcome in deep pain negative dogs with early surgical intervention, often surgery within 24 h DPN and PMM: one study found (Castel) an association between delay of decompression beyond 12 h and increased risk PMM, but literature overall lacking SURGERY Emerging evidence > focal or extensive hemilaminectomy and durotomy might decrease the risk PMM in dogs DPN and may improve survival in dogs with CS of PMM 2 Japanese retrospective studies reported a 91-100% survival rate with extensive hemi and durotomy, though most remained paralysed, including the FL if affected. Jeffery: 1 prospective study reported a reduced occurrence of PMM following extended durotomy (4 vertebrae) in G5 dogs AVCIM consensus suggests that extensive hemilaminectomy with durotomy can be considered for dogs with suspected PMM however, long-term morbidity (such as spinal instability) and how much surgery require further investigation
29
Effect of durotomy in dogs with thoracolumbar disc herniation and without deep pain perception in the hind limbs Fumitaka Takahashi
retrospective - increased recovery to ambulate with durotomy - no DPP, no dogs with durotomy developed PMM - not prevent progression of PMM - death 12%
30
Extended durotomy to treat severe spinal cord injury after acute thoracolumbar disc herniation in dogs Nick D. Jeffery
the small sample and the lack of a control group preclude definitive conclusions regarding the efficacy of durotomy.
31
Outcomes of dogs with progressive myelomalacia treated with hemilaminectomy or with extensive hemilaminectomy and durotomy Yuya Nakamoto
durotomy allow insepction of cord and reduce pressure
32
outcomes 1. normal nociception | most retrospective studies
-most reliable indiciator of prgnosis - 72-100% recovery (volunrary ambulate and uirnate) - excellent if ambul - increased sevrerity ~ increased recovery time - >90% nonambulatory will reover within 3 months if DPP present (most within 4 weeks) Davies 2022 - mean time to walk 14d
33
2.absent nociception | no test 100% predictive
-ensure conscious - 43-69% return to ambulate with Sx (Aikawaw 2012, Ruddle 2006) - if no pain in 2 weeks, prognosis poorer - recovery time 5-10 week - MRI lesion prgnostic (5x >L2 Ito 2005, levine 2009)
34
3, timing
contraversial Martin 7% benefit (g4 turn into 5) Upchurch no effect previous studies no bovious diff with duration f CS to decmopression > disparity, this intuituive to perform sooner
35
4.location
no diff in outcome (ruddle 2006)
36
5.size
larger slower to recover l1-l2 common, most type I, > 90% return to function
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6.type
22% successful outocme with protursion compared to 80% extrusion older lesions gradually compress causing irrevesible damage to cord
38
recurrence | with or without PF
reported rate of recurrence 0 – 24.4% with PF 2.7 – 41.7% without PF across multiple studies over the last 50 years definition of recurrence varies in the literature. Some studies include only patients with neurologic deficits and confirmed compressive lesions where as others also include those with any new signs of neck or back pain, so presumed IVDD without proving a disc-based cause 20% within 3 years (mayhew 2004) 40 % medically managed The number of radiographically opacified IVD increases the risk of recurrence 1.4x in non-Dachshund breeds. We know that IVDD is a body-wide condition in many affected animals and those that have symptomatic disease at 1 site are at risk for recurrence at another.   Furthermore, multiple studies have shown that almost 90% of thoracolumbar Type I IVDH occur between T11 and L3 So the goal of Prophylactic Fenestration is to creates a window in the anulus fibrosus to partially remove the nucleus pulposus > thereby reducing or preventing future extrusion of disc material
39
prophylactic fenestration early vs late
Early recurrences occur within 4 to 6 weeks of surgery and are usually always related to further extrusion at the same site of initial IVDH. Has a 1-5.8% reported incidence. Occur before the complete physiologic healing time of disc tissue Late recurrence is almost always at a new site- 87.5% occur at a disc space adjacent to or one disc away from the initial lesion
40
PF risk factors
Risk factors identified: > The presence of degenerate discs on imaging at the time of initial extrusion significantly increases the chances of a late recurrence > Mayhew: dachshunds at increased risk of recurrence, though this wasn’t supported by a later study by Brisson 2011. > Recently, Kerrs paper on French bulldogs suggested a 51% rate of recurrence in the breed
41
PF - tehcnique recent Hall survey > suggested an overall increase in the routine performance of fenestration, with surgeons (55%) and neurologists (82%).
Some or all discs from T11-L4 can be fenestrated – the no. depends of clinician preference and patient factors L4-5 and L5-6 > due to concern for injury of the nerve roots essential for weight bearing at that location traditional fenestration a #11 blade is used to create a window in the annulus a simple incision into the annulus to allow lateral escape of NP is ineffective long-term because the annulus rapidly heals So, manual fenestration involves removing nuclear material with the use of a dental scraper, curette or similar implements However, often residual NP is left, especially on the contralateral side of the disc (see picture) cadaver studies have been performed in attempt to improve the success. Holmberg study suggested that power fenestration (making a hole in AP larger with burr) improved percentage of disc removed, Forrtere study suggested even further improvement with an ultrasonic aspirator technique While these devices augment removal, none shown to besuperior to manual in clinical outcomes.
42
Percutaneous Laser Disc Ablation
Percutaneous Laser Disc Ablation minimally invasive fluoroscopy is used to guide percutaneous placement of needles, fine fiberoptic cable is passed into the center of the disk; the laser is activated low complication rate (<2%) The Dugat study reported recurrence of clinical signs over 3 years as (20%) dogs suspected > procedure may be dangerous to the spinal cord if there is rupture of the annulus, and current recommendations 6 weeks or more after any sx Forterre’s MRI study confirmed that all fenestrated dogs had residual material within the disk > allowing for potential of reherniation The effectiveness of fenestration, therefore would appear to be directly related to the skill and experience of the operator >>> whether removal of more nucleus corresponds to a greater prophylactic benefit has not yet been answered
43
arguments for PF
most common long-term complication after decompressive spinal surgery Good evidence that that a fenestrated disc is less likely to extrude Brisson found that its protective, with only 8% of recurrences occurring at a previously fenestrated site. Multiple studies shown most recurrences occur at a new disk space > 70% in a region that could have been readily fenestrated during the first surgery. Early recurrence is almost solely due to reherniation of the same disk space >>> radiographic evidence of mineralization at the herniated IVD space support fenestration of the affected disc space at the time of decompressive surgery >>> it is intuitive to consider if there was only low volume found during decompressive surgery. The reported complications rates appears very low, of >1,000 cases reported in the studies, complications from fenestration were noted in only 15 cases (0.01%) Avoids morbidity, costs, and potential choice of euthanasia for dogs affected a second or more Perhaps especially pertinent in dachshunds and French bulldogs.
44
recurrence rate PF vs no PF
There are lots of studies on outcomes of IVDD, but most have small numbers. These are the more pertinent large scale studies > as you can see, most are retrospective. The Necas + Mayhew are non Fenestration studies as a comparison Brisson 2011: Well- designed prospective trial compared the recurrence rate in dogs that underwent decompressive surgery and were either fenestrated at a single site or multi-disc There was a substantial reduction in risk of recurrence in the multifenestrated group (7% vs 17%) odds of recurrence at a nonfenestrated disk space were approximately 11 times the odds of recurrence at a fenestrated disk space Aikawa study: less that 3% recurrence rate of confirmed cases, and this is the results of ONE surgeon >>> extrusion at non-PF discs was found to be 26.2 times higher than that of PF discs Dugat laser ablation study > 3.6% recurrence, were confirmed by means of CT or MRI and hemilaminectomy
45
arguments agist PF
increase anaesthetics and surgical times (prolonged recovery, increased infection risk and increased surgery cost) displacement of disc material into the vertebral (important > where you cant check the vertebral canal– Harris 2020 showed this occurred in of 7/21 cases, >> clinical significance is unknown spinal cord trauma (worsening of neurologic deficits) Haemorrhage (including due to laceration of aorta) soft tissue and nerve root trauma (leading to postoperative pain, scoliosis and abdominal wall weakness) Difficulty identifying disc spaces for fenestration (including suboptimal removal of disc) Pneumothorax + Discospondylitis + vertebral subluxation and instability Fenestration of healthy discs leads to accelerate degeneration within disc and also affects biomechanics, > Hills biomechanical study revealed that fenestration most significant, single destabilizing factor when compared to hemilaminectomies >may result in abnormal biomechanical forces being exerted on the disks adjacent to the treated sites, leading to extrusion (so called ASD)
46
PF overtreating? Routine fenestration means that many more discs and dogs are being subjected to additional surgery than were ever going to have a clinically significant problem with those discs. If we take Mayhews nonPF outcomes > Hypothetically, because prognosis is good for the 19.2% of dogs that suffer a second episode of IVDD, performing a second decompressive surgery on only this subgroup of dogs may be preferable to performing unnecessary fenestrations in the other 80.8% that were never destined to have a recurrence. No evidence indicates that the prognosis is worse after a second hemilaminectomy
Several challenges exist in interpreting the existing literature on fenestration No studies have prospectively compared recurrence rates for patients with fenestration to those without fenestration Retrosepctive studies have no controls, no blinding, differences in # + sites of fenestration, the technique, surgeon’s skill level, follow-up time, and sample population While Brisson prospective study shows reduced recurrence with multi-disc PF, it doesn’t compare to not fenestration at all. And as I pointed out earlier, the overall incidence of recurrence may not be a low as suggested in the PF studies Mayhew > the incidence of recurrence without PF combined is 9.1% of 1,184 dogs across several studies , but the true incidence is no known due to these challenges of comparing literature. The large variation in recurrence number for both groups probably suggests there are multiple factors that influence recurrence and that fenestration is not a perfect solution
47
complications of TL IVDD intra-op (4)
heamorrhage iatrogenic damage wrong site inadeuate disc removal
48
post-op complications IVDD tL (9) post-op care
PMM 10% (olby, takahashi 2020) inadequte decompression instability infection 0.6% (dyall) reperfusion injury peridural fibrosis recurrence ongoing neuro deficits - 20% high grade urinary incontinence (skytte 2018) - most reocvery micturition before ambulation (90%) - G1-4 2-6 days - G5 14 days if deteriorate > cosndier reimage Post op care - analgesia, recumebency care, pneumonia/regurge - physio (olby 2005) 5 step protocol, possibly reduce post-op probpems and retunr to function quicker
49
name instruments
From left to right - Kirby intracapsular lens retractor hook - Angled nerve hook - House curette - Curved dental tartar scraper - Angled ball probe
50
urinary care
void via expression (only 50% out) vs indwelling or intermittent ucath q6-8hr: prospective study suggests that duration required to express rather than method associated with UTI Pelvic nerve (S1-S3) - Parasympathetic to detrusor muscle - motor - urine void (contraction) Pudendal nerve (S1-S3) - Somatic innervation - external urethral sphincter, perineal musculature, anal sphincter and skin of perineum - urine store: inc tone external sphincter - urine void: reduce external tone Hypogastric nerve (L1-L2) - Sympathetic innervation - internal urethral sphincter - detrusor muscle. - urine storage (b detrusor relax, a sphinctor increased tone >>Inhibits parasympathetic neurons during urine storage.
51
UMN bladder
large, firm, difficutl to express Tx: aim to reduce internal sphincter tone - prazosin (a1 specific, rapid) - phenoxybenzamine (a1 and a2, may reduce BP) reeduce external tone (diazepam) bethanacol if atony LMN: dt intact hypgastric casuing dtrusir to relax and non-intact pelvic/pudedal reduce sphinctor tone) STUDY: no improvement in urinary continence scores at the time of discharge from the hospital when medications given. development of bacteriuria was significantly associated with administration of medication
52
What are hemivertebrae? Block vertebrae? Butterfly vertebrae?
Hemivertebrae - Incompletely formed, wedge shaped vertebrae resulting from failure of one or more sclerotomes to form during embryogenesis. - Can prediapose Frenchies to lumbar IVDE and also place at higher risk of myelomalacia Block Vertebrae - Fused vertebrae due to failure of vertebral segmentation Butterfly vertebrae - A sagittal cleft witihin the vertebral body
53
What are the three forms of spina bifida?
Spina bifida occulta - no external evidence Spina bifida cystica - concurrent meningocoele, meningomyelocoele or myeloschisis Spina bifida aperta - open dysraphic/myelodysplastic disorders Spina bifida is failure of the lamina to fuse dorsally, often associated with other neural tube malformations
54
What is a pilonidal sinus?
A congenital condition wherein the skin failts to completely seperate from the neural tube. aka Dermoid sinus, Rh. Ridgebacks overrepresented
55
What is an epidermoid cyst?
Incomplete seperation of the neuroectoderm from the ectodermal tissue, trapping viable ectodermal cells within the CNS
56
What is a subarachnoid diverticula?
A focal accumulation of CSF within the arachnoid membrane or subarachnoid space. Controversy if this causes cord compression and subsequent atrophy or if spinal cord atrophy leave extra space which then fills with CSF Pugs and Rottweilers overrepresented Surgical marsupialisation best outcome
57
What is myelodysplasia?
Incomplete or abnormal fusion of the neural tube along the sagittal plant. Aka dysraphism Weimeraners overrepresented. Microscopic - no visible on CT myelogram. All dogs will have a bunny-hopping gait
58
Surgical Site Infection Rate after Hemilaminectomy and Laminectomy in Dogs without Perioperative Antibiotic Therapy Barbara A.R. Dyall 2018
SSI Rate in hemi without Perioperative Antibiotic. retrospectively review the surgical site the SSI rate was 0.6% (expected SSI rate in clean 2.0 to 4.8% ) the routine use of perioperative antibiotic prophylaxis should be reconsidered
59
Fowler 2022 – feline thoracolumbar IVDD in 35 cats - clinical signs: difficulty walking most common (54.2%) - localisation: 57% L4-S3 → L6-L7 most common site (34%) - outcome: surgery: 20/32 (62.5%) improved at discharge, 21/23 (91.3%) at 2 week recheck - not associated with grade at presentation - overall 75% improvement, 2/3 (66.6%) g5 improved by discharge - mortality: 5/32 (14.3%) euth or death post-op | JFMS
JAVMA study: The prevalence of feline IVDD significantly increases with progressive age, with the thoracic and cervical IVDs showing the highest odds for degeneration. However, extreme stages of IVDD were only occasionally observed
60
Clinical presentation, diagnosis, treatment and outcome of spinal epidural empyema in four cats (2010 to 2016) S. Guo
Three cats were treated by surgical decompression plus antimicrobial therapy and one cat was treated medically. All cats showed satisfactory improvement following treatment over a follow-up period of 3 months. Spinal epidural empyema is a rare condition but all cats in this series had favourable outcomes.
61
Same-day surgery may reduce the risk of losing pain perception in dogs with thoracolumbar disc extrusion S. Martin 2020
Retrospective, single centre study on 273 client Seven of 151 dogs in the early surgery group lost pain perception overnight compared to 15 of 122 in the delayed surgery group - recovery of pain perception (by 3w): 5/7 early sx, 8/14 delayed This study suggests that an overnight delay before spinal decompression increases the risk of clinically meaningful deterioration in dogs unable to walk following thoracolumbar disc extrusion.
62
Introduction of Disc Material into the Vertebral Canal by Fenestration of Thoracolumbar Discs Following Decompressive Surgery Georgina Harris 2020
Twenty-one dogs that underwent hemilaminectomy and fenestration 7/21 new disc material in the vertebral canal post fenestration (33%) Conclusion This illustrates the importance of checking the vertebral canal after fenestration of an extruded intervertebral disc.
63
Minimally invasive spine surgery in dogs: Evaluation of the safety and feasibility of a thoracolumbar approach to the spinal cord Julien Guevar
Study design: Prospective study. Animals: Six healthy research dogs. - fluoroscopic positioning (radiation) with operating microscope - vertebral canal successfully accessed → visualisation of ventral aspect of spinal cord - no complications, post-op pain not different to baseline in 5/6 dogs
64
Effect of Duration and Onset of Clinical Signs on Short-Term Outcome of Dogs with Hansen Type I Thoracolumbar Intervertebral Disc Extrusion David A. Upchurch 2020 | time is continuous, subject to recall bias.
duration of pre-op clinical signs and rate of onset not correlated with return of pain sensation, urinary continence or ambulation - pre-op neuro grade main variable associated with recovery/outcome - more severe (gr0) → slower time to recovery of urinary continence, less likely to return to ambulation, longer recovery time to ambulation timing of surgery for the dogs in this retrospective study was decided by the clinicians. As a result, there may have been a bias
65
Three-dimensionally printed patient-specific drill guides are a safe and effective method of placing pedicle screws in dogs with thoracolumbar vertebral malformations.
66
Relationship of preoperative neurologic score with intervals to regaining micturition and ambulation following surgical treatment of thoracolumbar disk herniation in dogs Ditte Skytte 2018
Retrospective case series with nested cohort study 54 dogs weighing < 20 kg (44 lb) that were surgically treated for Hansen type 1 IVDE 54 dogs weighing < 20 kg (44 lb) that were surgically treated for Hansen type 1 IVDE
67
Agreement of surgeon’s perception of the effectiveness of spinal cord decompression with findings on postoperative magnetic resonance imaging for dogs surgically treated for intervertebral disk extrusion Federica Tirrito
surgeon’s perception of adequate spinal cord decompression may be less reliable than postoperative MRI findings.
68
Effect of irrigation technique on the vertebral canal temperature during thoracolumbar hemilaminectomy in dogs: An ex vivo study Dongaonkar 2021
Ex vivo study. bolus intermittent irrigation maintains lower vertebral canal temperature vs continuous Drilling was performed for 15 s followed by a 10-s pause
69
Outcomes of dogs with progressive myelomalacia treated with hemilaminectomy or with extensive hemilaminectomy and durotomy Yuya Nakamoto 2021
Study design: Retrospective clinical study. 28 dogs. EHLD – cranial extension → length of T2W intramedullary hyperintensity (6-13 sites) - PMM diagnosed macroscopically or presumptive in HL group - return to ambulation not discussed - survival rate: HL-alone 11/18 vs ELHD 10/10
70
Thoracic Vertebral Canal Stenosis Associated with Vertebral Arch Anomalies in Small Brachycephalic Screw-Tail Dog Breeds conte 2021
presentation: non-painful pelvic limb ataxia, paraparesis - T4-T5 stenosis most common in neurologically affected (10/185) - stenosis more severe in neurologically affected: stenotic ratio 0.56 67% sens/spec - clinical improvement (9/10) or stasis (1/10) with medical or surgical tx - T2-T3 most common in normal dogs (33/175)
71
Late onset recurrence of clinical signs after surgery for intervertebral disc extrusion in French bulldogs S. Kerr 2021
Forty-three (51%) dogs that had decompressive surgery for thoracolumbar (n=29) or cervical (n=14) intervertebral disc extrusion suffered recurrence of signs. The median time between decompressive surgery and recurrence of clinical signs was 9 months and 21 days
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Transthoracic Vertebral Distraction and Stabilization in 10 Dogs with Congenital Thoracic Vertebral Malformations Mariné 2021
common findings in screw-tailed brachycephalic breeds and in pugs. cause neurological signs due to spinal cord compression, instability or both. Medicalmanagement of CTVBM has been associatedwith an unfavourable outcome, leading to the progression Most described techniques have used a dorsal approach transthoracic vertebral distraction-stabilization for congenital thoracic vertebral malformations - intercostal thoracotomy → Caspar distractor → screw/PMMA - age at sx 5-43m (majority <10m) - 1/10 cardiac arrest 24hr post-op - Cobb angle improvement (33-83°→10-46°); vertebral canal angle improvement - neurological improvement: 9/10 improved post-op, 7/9 neurologically normal
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Clinical outcomes of 20 brachycephalic dogs with thoracolumbar spinal deformities causing neurological signs treated with spinal stabilization using 3D-printed patient-specific drill guides Violini 2024
spinal stabilization with 3D-printed drill guides for TL spinal deformities - 12 pugs, 8 French Bulldogs – 19/20 gr2, 1/20 gr1 - 3D printed drill guide → pedicle screws and PMMA - no post-op complications, optimal screw placement 169/201 - neurological function: 16/20 no change at 24hr post 17/20 static, 2/20 improved short term 6/10 static, 3/10 improved at median 883.5d
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Outcomes and prognostic indicators in 59 paraplegic medium to large breed dogs with extensive epidural hemorrhage secondary to thoracolumbar disc extrusion Christian W. Woelfel
Retrospective, Fifty-nine client-owned dogs outcomes and prognostic indicators for medium-large breed with extensive epidural hemorrhage secondary to IVDD - 22/59 DP, 37/59 DPN - return to ambulation: DPP 17/22 (77.3%), DPN 14/37 (37.8%) - PMM in 3/59 (5.1%) - 1/3 DPP, 2/3 DPN -negative: signal interruption on HASTE, DPN - longer decompression → better outcome - pathophysiology: epidural hemorrhage → compression, reduced perfusion > SCI
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Hydrated Nucleus Pulposus Extrusion in Dogs: Thoracolumbar Compared to Cervical Cases K. V. Kristiansen 2022
Study Design Retrospective, single-center study. Results Thirty-six dogs More TL HNPE (11/21) were treated surgically compared with C HNPE (4/15) HNPE – TL vs cervical cases - TL HNPE → spinal hyperaesthesia, disc material more often lateralized - >90% acute onset with vigorous activity; median gr3, 72.2% non-ambulatory - outcomes similar to cervical HNPE – 100% recovery of ambulation (fu 30d), 21.7% full
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Evaluation of the intervertebral disk, vertebral body, and spinal cord for changes secondary to percutaneous laser disk ablation Irizarry 2022
percutaneous laser disc ablation - applied to T10-L5 to reduce recurrence after previous IVDD - appeared safe – MRI detected endplate lesions and mild diskitis concern was raised in a previous study regarding effectiveness in dehydrated and mineralized disks, documenting recurrence at disk sites that were shown to have complete/ mature mineralization present at the time of PLDA
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2022 Eighteen dogs with caudal lumbar intervertebral disc extrusion causing tail dysfunction, urinary and/or faecal incontinence were included.
Urinary continence was recovered in 12 (86%) of 14 affected dogs, faecal continence recovered in nine (90%) of 10 affected dogs and tail function recovered in 13 (87%) of 15 affected dogs. The prognosis for functional recovery following surgical treatment is good.
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Tube cystostomy is effective for urinary outflow management in dogs with intervertebral disk extrusion and ischemic myelopathy cranial to the L3 spinal cord segment: 61 dogs (2018–2022) Nash 2023 | how compare to U-cath?
61 dogs. complications were reported, mainly inadvertent removal (n = 11) and peristomal urine leakage (6). Tube cystostomy facilitates early hospital discharge and allows at-home, extended urinary management in dogs .reported as easy to use by owners positive culture was confirmed in 11 of 13 dogs (85% of dogs tested, 20% of dogs with follow-up data available). U-cath infections common (30-55%) | 4 of the 39 (10.3%) dogs developed a UTI
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Thoracolumbar Intervertebral Disk Extrusion in Dogs: Do Onset of Clinical Signs, Time of Surgery, and Neurological Grade Matter? Krizia Compagnone 2023
433 dogs impact of clinical signs, time to surgery and neuro grade for IVDD - poorer outcome: acute onset of clinical signs, worse neuro grade (DPN) at presentation - duration of clinical signs and time of sx not correlated with time to recovery, return of pain sensation, urinary continence or ambulation - return to ambulation: 72.7% overall - 32% full, 40.7% partial, 13.8% incomplete, 7.9% poor - 5.6% progression of disease or PMM Conclusion Dogs presented with severe neurological status and/or rapid onset of clinical signs were operated on more promptly, but their outcomes were also poorer. There was no significant evidence for a better outcome when surgery was not delayed.
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Decompressive laminectomy with vertebral stabilization allows neurologic improvement of most Pekingese dogs with thoracolumbar vertebral instability Aikawa low frequency of FGF4 expression
The concept of vertebral instability as the cause of the spinal cord injury has been controversial and sparsely investigated in veterinary medicine APs contribute up to 30% of the stability of the vertebral column in normal dogs In a recent report18 on Pug dogs, dynamic myelographic study was used to confirm single or multiple dynamic thoracolumbar spinal cord compressive lesions associated with or without AP anomalies. The decompression and stabilization of these segments resulted in good outcomes.18
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The volume of extruded materials is correlated with neurologic severity in small-breed dogs with type I thoracolumbar intervertebral disk herniation Sakaguchi 2023
total volume of the materials that had extruded into the vertebral canal plus the intervertebral space was greater than the volume of the intervertebral disks without herniation There was a weak positive correlation between the volume of the extruded materials at the herniated site and the neurologic severity Previous studies have found that the maximal transverse spinal cord compression ratio is not correlated with neurologic severity in dogs with type I TL-IVDH on the basis of MRI images.9,10
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Prevalence of gastroesophageal reflux in dogs undergoing MRI for a thoracolumbar vertebral column pathology E. Paran 2023
Fifty percent of included dogs had evidence of gastroesophageal reflux. Brachycephalic dogs did not demonstrate significantly higher rates of reflux compared to non-brachycephalic dogs.
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Does surgical timing affect the rapidity of recovery in deep pain-entire nonambulatory dogs with thoracolumbar intervertebral disk extrusion? L. Vicens Zanoguera 2023
Prospectively. effect of timing of sx on rapidity of recovery for G4 TL IVDD - all dogs operated within 72hr (variation in timing short) - only 14.5% had delay >6.5 hour - 148/151 (98%) return to ambulation – all cases recovered ambulation within 30d (med 5d) - residual neuro deficit: 81/151 gr2 (53.6%), 4/151 gr1 (2.6%) 63/151 (41.7%) gr0
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The frequency at which spontaneous resolution of disc-associated compression occurs in dogs is unknown, because most affected cases either do not undergo cross-sectional imaging or, alternatively, undergo surgical decompression. In this case, there was rapid improvement in neurologic function, but it is unclear if that was a consequence of spontaneous resolution of compression or arose through purely neurologic recovery mechanisms.
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The presence, morphology and clinical significance of vertebral body malformations in an Australian population of French Bulldogs and Pugs JD Brown 2021 | genetic link between screw tails and CVM in bulldog
Prospective cohort study series. Materials and methods Forty-nine French Bulldogs and Pugs vertebral body malformations in French bulldogs and pugs - breed-associated malformations: French bulldogs – butterfly vertebra; Pugs – transitional - new subtype: dorsal wedge described - neurological deficits - not associated with presence, number or subtype of malformation - Pugs – neuro deficits associated with Cobb angle >35° (kyphosis) - French Bulldogs → pathology distant to vertebral malformation – IVDD most common
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Chondrodystrophy is a genetic disorder resulting from the presence of 1 or more copies of the fibroblast growth factor 4 retrogene
presence of IVD calcification was higher in dogs with 2 copies of FGF4L2 (84.8%) compared to 0 copies (18.5%).1 However, data from a prospective, controlled study lacking.
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Relationship between breed, hemivertebra subtype, and kyphosis in apparently neurologically normal French Bulldogs, English Bulldogs, and Pugs | AJVR
high degree of kyphosis may not be the only risk factor for development of clinical disease, as is suggested by previously reported findings of high Cobb angles exceeding 35° in French Bulldogs without neurologic deficits.18 Indeed, Cobb angle measurements may not represent all clinically important characteristics of spinal curvature abnormalities.
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Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion **Mehra 2023** reported in 15-47% of dogs undergoing surgery for acute TLIVDE | initiated 2 weeks b4??
Conclusions and Clinical Importance: Short-term, prophylactic omeprazole treatment did not decrease clinically detectable GI complications in dogs with acute TL-IVDE. Consistent with this conclusion, previous studies have shown that prophylactic omeprazole, cimetidine, sucralfate, or misoprostol treatment does not decrease clinical GI complications or mucosal evidence or progression of GI lesions in dogs
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Functional Obstruction: Detrusor Urethral Dyssynergy | these animals typically have an otherwise normal neurologic examination
abnormality in the reflex arc that allows the urethral sphincter to relax at the initiation of detrusor contraction and urination. The lesion is thought to be in the reticulospinal tract, Onuf nucleus, or the caudal mesenteric ganglion, and it is possible that the lesion involves the loss of inhibitory signals to the pudendal and hypogastric nerves Clinical signs are similar to those of mechanical obstruction. The animal often postures to urinate and is able to produce a urine stream that quickly becomes attenuated or stops completely. Ultrasonography is recommended to assess the ureters and renal pelves. Additional diagnostics, including contrast urethrography, urethroscopy, or urodynamic evaluation, may be necessary to verify the diagnosis treatment: prazosin, an alpha1adrenergic-specific antagonist with demonstrated effects on both the internal and external urethral sphincters. Tamsulosin, which is specific for the alpha1A subtype found in the internal urethral sphincter, has alsobeen successful in these dogs. Some dogs require additional therapy if the striated muscle is more significantly affected. Benzodiazepines, severe and refractory cases, intermittent sterile catheterization by the owner at home may be necessary Prognosis for recovery of normal voiding is good, but most dogs require lifelong therapy for DUD.
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Scalia 2024 – use of clinical reasoning in dogs with acute TL myelopathy and/or pain - decision-making based on presentation and neuro-exam findings → case management without cross-sectional imaging - ambulatory dogs with IVDD → 80% chance of successful outcome treated medically - deterioration → surgical management → 100% successful outcome - ischemic myelopathy/ANNPE → 94% successful outcome without x-sectional imaging
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Auffret 2024 – residual disc material and cord compression on post-op MRI after surgery - prevalence of residual extradural material 17/17 (100%) - decompression → reduction of ~75% volume of extradural material → 24.5% mean spinal cord decompression - outcome not associated with: mean pre-op compression, mean residual compression, mean decompression, volume of residual extradural material
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Intervertebral disc protrusion (Type 2): Crawford 2018 – hemilaminectomy with annulectomy vs partial discectomy for Type 2 IVDD - early post-op neuro deterioration: 16/29 hemilam+annulectomy vs 7/24 hemi+discectomy - clinical improvement (min 18m): 9/22 H+A vs 17/23 H+PD - H+PD → decreased post-op deterioration, increased clinical improvement
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Jeffery 2024 – randomized controlled trial – adjunct durotomy for severe acute IVD (DPN) - recovery of ambulation: 65/128 (51%) - traditional decompression: 35/62 (56%) - adjunct durotomy: 30/66 (45%) - 10/128 (7.8%) PMM - trial unable to reach target 15% improvement → termination - durotomy ineffective at improving functional outcome for severe acute spinal cord injury | neurotrauma J
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Jeffery 2020 – extended durotomy for severe spinal cord injury (DPN) after TL IVDD
- extent of surgery: laminectomy → 2 vert body lengths cranial and caudal durotomy – not standardised – based on CSF signal (min 4 vert body) - recovery to ambulation: 16/26 (61.5%); 1/16 PMM → euthanasia - appeared to improve outcome – calculated recovery rate 71% - herniation of softened/liquid cord → non-rcovery - no adverse effects of durotomy
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Castel 2017 – progressive myelomalacia after type 1 IVDD - mid-caudal lumbar disc herniations common - neurological grade at presentation: majority DPN - 12/51 (25%) DPP: 9/12 Gr2-3, 3/12 Gr2 - onset of PMM: at presentation (17/51), within 48h (25/51) - progression of PMM 1-13d
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Effect of durotomy in dogs with thoracolumbar disc herniation and without deep pain perception in the hind limbs Takahashi 2020
Takahashi 2020 – effect of durotomy in DPN TL-IVDD - return to ambulation: durotomy → higher rate 56.9% vs hemilaminectomy alone 38.5% - associated with: durotomy, breed, surgical site, T2W hyperintensity length:L2 body - French Bulldog → less likely to have good recovery - Mini-Dachshunds → more likely to have good recovery - thoracic/TL site → poorer recovery vs lumbar - T2W:L2 ratio >6 → 22.6% return to ambulation vs 2-4 75% - incidence of PMM: 14/65 hemilaminectomy alone died of suspected PMM, vs 0 durotomy
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Investigating the weekend effect in decompressive thoracolumbar hemilaminectomy for acute intervertebral disc extrusion: An observational cohort study of 460 cases (2018–2023) Low 2024
retrospective. investigate if weekend surgery is associated with poorer outcomes 401 weekday and 59 dogs weekend Cohort Weekend had a higher risk of not recovering ambulation compared to Cohort WD 79.2% vs. 91.6% recovery
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Clinical, magnetic resonance imaging, histopathological features, treatment options and outcome of spinal ependymoma in dogs: 8 cases (2011–2022) Camera 2024
retrospective intramedullary oval-shaped space-occupying lesions that appeared hyperintense on T2-weighted images rare primary neural tumours that originate from the ependymal lining of the ventricles and central canal of the spinal cord Surgery offered a dual benefit by facilitating intra-vitam diagnosis and, in some cases, extending survival time All surgically treated (5 dogs) except one (case 8) showed a mild post-operative neurological deterioration; none of the paretic dog became paralysed and, moreover, they all showed improvement within the first week after surgery symptoms relapsed, owners opted for euthanasia.
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Retrospective study of partial lateral corpectomy to treat thoracic and lumbar intervertebral disc herniation in 12 cats Tyroller 2024
thoracic or lumbar partial lateral corpectomy (PLC) in cats with spinal cord compression due to intervertebral disc herniation (IVH). Outcomes: 5 cats with an excellent result, 3 with significant improvement, 1 mild improvement and 3 cats that died haemorrhage > 25% mortality rate.
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Spinal magnetic resonance imaging in cats: differences in clinical significance of intervertebral disk extrusion, intervertebral disk protrusion, and degenerative lumbosacral stenosis Soteras 2024
The most common change was IVDD, followed by SD and intervertebral disk protrusion (IVDP), while intervertebral disk extrusion (IVDE) were uncommon to rare. Primary complaint was attributed to a degenerative condition in 22% of cats, including 100% with IVDE, 9% with IVDP, and 43% with degenerative lumbosacral stenosis DLSS for signs of myelopathy, IVDE was always responsible for the clinical presentation IVDP and DLSS might not be associated with the reason for consultation in cats presenting with signs of myelopathy