Ch 3 lecture Tissues Flashcards
- Tissues
a. Groups of closely associated cells that perform related function and are similar in structure
- What are the four major categories of tissues
a. Epithelial
b. Connective
c. Muscle
d. Nervous
- Histology
a. The study of tissues
b. Provides the structural basis for a study of organ physiology
- What is an epithelium
a. F
- Epithelia
a. The tissues that covers the external body surface (epidermis), lines it cavities and tubules
b. “marks off our insides from our outsides.”
- Are glands epithelium?
a. Yes
b. Since glands develop from epithelial membranes they are also classed as epithelium
- What are some functions of epithelium?
a. Protection, absorption, filtration, secretion and sensory reception
- What are the unique characteristics of epithelial tissues
a. Cellularity, special contacts, polarity, supported by connective tissue, avascular but innervated, high regenerative capacity
- Cellularity
a. Composed almost entirely of cells
- Special contacts
a. Form continuous sheets held together by tight junctions and desmosomes
- Polarity
a. Apical (upper free)
b. Basal (lower attached) surfaces
- Supported by connective tissue
a. Reticular and basal laminae (basement membrane)
- Avascular but innervated
a. A
- High regenerative capacity
a. Rapidly replaces lost cells by cell division
- Epithelia are classified according to two criteria
a. Arrangement or relative number of layers (first name of tissue)
b. Cell shape (last name if tissue
- Arrangement of epithelia?
a. Simple and stratified
b. Simple
i. Consisting of one layer of cells attached to the basement membrane
c. Stratified
i. Consisting of two or more layers of cells
- Types of epithelia
simple, cuboidal, columnar
a. Squamous
i. Cells wider than tall (plate-like)
ii. Nuclei top
b. Cuboidal
i. Cells are as wide as tall (cube-like)
ii. Nuclei middle
c. Columnar
i. Cells are taller than they are wide (column-like)
ii. Nuclei bottom
- Stratified epithelia are named?
a. According to the cells at the apical surface of the epithelial membrane, not those resting on the basement membrane
- Pseudostratified epithelium
a. Simple columnar epithelium
b. Cells vary in height and nuclei lie at different levels above the basement membrane
c. Ciliated
- Transitional epithelium
a. Stratified squamous epithelium are formed of rounded, or “plump” cells with the ability to slide over one another to allow the organ to be stretched
b. Only found in urinary system organs
i. Bladder
- Simple squamous epithelium
a. A single layer of flat cells with disc shaped nuclei and sparse cytoplasm
- Function of simple squamous epithelium
a. Passage of materials by passive diffusion and filtration and secretes lubricating substances in serosae (membranes)
- Special types of simple squamous epithelium
a. Endothelium
b. Mesothelium
- Endothelium
a. Inner covering
b. Slick lining of hollow organs
- Mesothelium
a. Middle covering
b. Lines peritoneal, pleural, and pericardial cavities
c. Covers visceral organs of those cavities
- Simple squamous epithelium location
a. Renal corpuscles, alveoli of lungs, lining of heart, blood and lymphatic vessels, lining of ventral body cavity (serosae)
- Simple cuboidal epithelia
a. Single layer of cube-like cells with large, spherical central nuclei
- Functions of simple cuboidal epithelium
a. Secretion and absorption
- Location of simple cuboidal epithelial
a. Kidney tubules, secretory portion of small glands, ovary surface
- Simple columnar epithelia
a. Single layer of column-shaped (rectangular) cells witih oval nuclei
b. Some bear cilia at their apical surface
c. May contain goblet (mucus secreting) cells
- Simple columnar epithelia functions
a. Absorption
b. Secretion of mucus, ion transport, ciliated type propels mucus or reproductive cells by ciliary action
- Location of simple columnar epithelia
a. Non-ciliated form
b. Lines digestive tract, gall bladder, ducts of some glands
Ciliated form- b. Lines small bronchi, fallopian tubes, and uterus
- Pseudostratified columnar epithelial
a. All cells originate at basement membrane
b. Only tall cells reach the apical surface
c. May contain goblet cells and bear cilia
d. Nuclei lie at varying heights within cells
e. Gives false impression of stratification
- Function of pseudostratified columnar epithelial
a. Secretion of mucus
b. Propulsion of mucus by cilia
- Location of pseudostratified columnar epithelia
a. Non-ciliated form
b. Ciliated form
- Non-ciliated form of pseudostratified columnar epithelia location
a. Ducts of male reproductive tubes and ducts of large glands
- Ciliated form of pseudostratified columnar epithelia location
a. Lines trachea and most of upper respiratory tract
- Stratified squamous epithelium
a. Many layers of cells
b. Superficial layers are squamous in shape while deeper layers of cells appear cuboidal or columnar
c. Thickest epithelial tissue
d. Adapted for protection
- Function of stratified squamous epithelium
a. Protects underlying tissues in areas subject to abrasion
- Location of stratified squamous epithelium
a. Keratinized forms – epidermis
b. Non-keratinized forms
i. Lining of esophagus, mouth, and vagina
- Stratified cuboidal epithelium
a. Generally two layers of cube-shaped cells
- Function of stratified cuboidal epithelium
a. Protection
- Location of stratified cuboidal epithelium
a. Forms largest ducts of sweat glands and forms cuts of mammary glands and salivary glands
- Stratified columnar epithelium
a. Several layers
b. Basal cells usually cuboidal
c. Superficial cells elongated
- Function of stratified columnar epithelium
a. Protection and secretion
- Location of stratified columnar epithelium
a. Rarest tissue types
b. Found in male urethra and large ducts of some glands
- Transitional epithelium
a. Basal cells usually cuboidal or columnar
b. Superficial cells dome-shaped or squamous
c. Undergoes transition in shape
- Function of transitional epithelium
a. Stretches
b. Permits distention of urinary bladder causing thinning
i. From 6 to 3 layers when filled with urine
- Location of transitional epithelium
a. Lines ureters
b. Urinary bladder
c. Part of urethra
- Gland
a. Many epithelial cells that make and secrete a product
- The products of a gland are?
a. Aqueous fluids that usually contain proteins
- Epithelial cells forming glands are highly specialized to?
a. Remove materials from the blood
b. Manufacture them into new materials, which they secrete (recall RER)
- Glands are classified by?
a. Site of release: endocrine (“internally releasing”) vs. exocrine (“externally releasing”)
b. The relative number of cells forming the gland
- Endocrine glands
a. Lose their surface connection (duct) as they develop
b. Referred to as “ductless glands”
- Endocrine glands secrete hormones to?
a. Directly into the blood or the lymphatic vessels that weave through the glands to specific target organs farm from the site of release
- Exocrine glands
a. Retain their ducts, and their secretions empty through these ducts to an epithelial surface
b. Internal and external
- In addition to the site of product release, glands are also classified based upon the?
a. Relative number of cells forming the gland: unicellular and multicellular
- Unicellular
a. Scattered within epithelial sheets
- Multicellular
a. Formed by invagination or invaginations and usually have ducts that carry products of exocrine glands to epithelial surface
- Ducts
a. Tube-like connections to epithelial sheets
- Unicellular exocrine glands
a. The goblet cell
b. Scattered through epithelial lining of intestines and respiratory tubes, between columnar cells
- Goblets cells produce
a. Mucin
- Mucin
a. Glycoprotein that dissolves In H2O to become slimy
i. Mucin + water = mucus
b. Covers, protects, and lubricates many internal body surfaces
- Multicellular exocrine glands: two basic parts
a. Secretory unit
b. Epithelium-walled duct
- Multicellular exocrine glands classified by structure of duct
a. Simple (unbranched), compound (branched)
- Multicellular exocrine glands categorized by secretory unit structure
a. Tubular
b. Alveolar = acinar
c. Tubuloalveolar
- Tubular
a. Secretory cells form tubes
- Alveolar = acinar
a. Secretory cells form small flask-like sacs
- Lateral surface features: Three factors act to bind epithelial cells to one another
a. Adhesion proteins in the plasma membranes link together adjacent cells
b. The wavy contours of the membranes of adjacent cells (tongue and groove)
c. Special cell junctions
- Lateral surface features: cell junctions
a. Tight junctions (zonula occludens)
i. Belt-like junction that extends around periphery (apical region)
ii. Closes of extracellular space
iii. Some proteins in plasma membrane of adjacent cells are fused
- When proteins in plasma membrane of adjacent cells are fused it?
a. Prevents molecules from passing between cells of epithelial tissue
- Lateral surface features: cell junctions
a. Adherens junctions (zonula adherens)
i. An anchoring junction just below tight junctions
ii. Transmembrane linker proteins attach to actin microfilaments of the cytoskeleton and bind adjacent cells
- Adherens junction with tight junctions
a. Form the tight junctional complex around apical lateral borders of epithelial tissues
- Lateral surface features: cell junctions
a. Desmosomes
i. Anchoring junctions
ii. Main junctions for binding cells together
iii. Two disc-like plaques connected across intercellular space
- Desmosomes plaques of adjoining cells are joined by?
a. Proteins called cadherins
- Cadherins proteins interdigitate into?
a. Extracellular space
- Intermediate filaments of desmosomes insert into plaques from?
a. Cytoplasmic side
- Lateral surface features: cell junctions
a. Gap junctions (nexus)
i. Tunnel-like passageway between two adjacent cells (anywhere)
ii. Let small molecules move directly between neighboring cells
- Cells in gap junctions are connected by?
a. Hollow cylinders of protein (connexons)
- Basal surface feature:
a. Basal lamina
- Lateral surface features?
a. Cell junctions
- Apical surface feature?
a. Microvilli
b. Cilia
c. axoneme
- Basal lamina
a. The border between the epithelia and the underlying C.T
b. Non-cellular supporting sheet of proteins secreted by epithelial cells
- Functions of basal lamina
a. Acts as a selective filter, determining which molecules from capillaries enter the epithelium
b. Acts as scaffolding along which regenerating epithelial cells can migrate
- What forms the basement membrane?
a. Basal lamina and reticular layers of the underlying connective tissue deep to it
- Clinical application of basal lamina in Untreated cases of DM
a. Basement membrane associated with endothelium of capillaries thicken over time, probably because that take up glucose which is present in very high concentration
- Why is kidney failure and blindness are major symptoms of diabetes
a. Thickening in especially evident in capillaries of kidneys and the retina of the eyes, making them nonfunctional
- Microvilli
a. Finger like extensions of plasma membrane
b. Maximize surface area across which small molecules enter or leave
c. Abundant in epithelia of small intestine and kidney
- Apical surface features: cilia
a. Whip-like, highly motile extensions of apical surface membranes
- Apical surface features: cilia
a. Axoneme
i. Set of microtubules
ii. Contains a core of nine pairs of microtubules encircling one middle pair
iii. Each pair of microtubules arranged in a doublet
- Movement of cilia
a. Coordinated waves