Cell Physiology figures and parameters

Question 1

I. Parameters
1. Body water content?

Answer 1

42L

Question 2

I. Parameters
2. Blood volume?

Answer 2

5.5L

Question 3

I. Parameters
3. Plasma volume

Answer 3

3.5L

Question 4

I. Parameters
4. ECF volume?

Answer 4

14L

Question 5

I. Parameters
5. Intracellular fluid Volume?

Answer 5

28l

Question 6

I. Parameters
6. Interstitial fluid volume?

Answer 6

10.5L

Question 7

I. Parameters
7. Hematocrit?

Answer 7

0.42 - 0.46

Question 8

I. Parameters
8. Hemoglobin concentration?

Answer 8

12 - 16g/ dl (~120 - 160g/L)

Question 9

I. Parameters
9. Blood plasma Na+ concentration

Answer 9

135 mM - 147 mM

Question 10

I. Parameters
10. Blood plasma H+ concentration

Answer 10

10^-7.4 mM (pH 7.4)

Question 11

I. Parameters
11. Blood plasma K+ concentration

Answer 11

3.5 - 5 mM

Question 12

I. Parameters
12. Blood plasma Ca2+ concentration and its fractions

Answer 12

1.1 - 1.4 mM (free)
2.1 - 2.8 mM (total)

Question 13

I. Parameters
13. Blood plasma Cl- concentration

Answer 13

95 - 105 mM

Question 14

I. Parameters
14. Blood plasma HCO3- concentration

Answer 14

22 - 28 mM

Question 15

I. Parameters
15. What are blood plasma osmolarity?

Answer 15

290 mOsm

Question 16

I. Parameters
16. What is the blood plasma pressure?

Answer 16

28 mmHg (80% of it comes from albumin)

Question 17

I. Parameters
17. What is Resting membrane potential of skeletal muscle cells?

Answer 17

-87 mV (~ -90 mV)

Question 18

I. Parameters
18. What is the Resting membrane potential of neurons?

Answer 18

-70 mV

Question 19

I. Parameters
19. Conduction velocity of A-alpha nerve

Answer 19

A-alpha: 80 - 120 m/s

Question 20

I. Parameters
20. What is Equilibrium potential of Na+ in neurons?

Answer 20

+60 mV

Question 21

I. Parameters
21. What is Equilibrium potential of K+ in neurons?

Answer 21

-90 mV

Question 22

I. Parameters
22. What is Equilibrium potential of Ca2+ in neurons?

Answer 22

+120 mV

Question 23

I. Parameters
23. What is Equilibrium potential of Cl- in neurons?

Answer 23

-70 mV

Question 24

II. Cell Physiology Figures
1A. Action potential of a mammalian motor neuron. Give values of both axes!

Answer 24

Question 25

II. Cell Physiology Figures
1B. Action potential of a mammalian motor neuron.
-> Interpret the diagram

Answer 25

Question 26

II. Cell Physiology Figures
2A. Action potential and changes in contraction force of a muscle fiber during a single twitch

Answer 26

Question 27

II. Cell Physiology Figures
2B. Action potential and changes in contraction force of a muscle fiber during a single twitch
-> Interpret

Answer 27

Feature of skeletal muscle contraction
-> has a very short AP (~ 5ms) and [Ca2+]IC increases shortly after the peas
-> then a twitch force is generation
=> AP can be generated more before the Ca2+ signal terminates => allow temporal summation

If AP frequency increases
-> Increased Ca2+ release is maintained
=> muscle tetanized

Question 28

II. Cell Physiology Figures
3. Action potentials and changes in contraction force during single twitch, incomplete and complete tetanus of a muscle fiber. (Draw the curves in proportion to each
other in their amplitudes and duration!)

Answer 28

Question 29

II. Cell Physiology Figures
4. Length-tension relationship of a skeletal muscle fiber. Give values of both axes!

Answer 29

Question 30

II. Cell Physiology Figures
5A. End plate potentials before and after the application of curare.

Answer 30

Question 31

II. Cell Physiology Figures
5B. End plate potentials before and after the application of curare.
-> Interpretation

Answer 31

Inhibition of nAChR
-> decrease the end plate potential (EPP)
-> Not enough to exceed the threshold of voltage dependent of Na+ channel -> No AP