2.4B. (Pump function of the heart.) Cardiac output and its control. Flashcards
I. Cardiac output
1. What is cardiac output?
Cardiac output (CO) is the volume of blood being pumped by the left ventricle into the aorta per minute
- CO = 5,6 L/min at rest
- CO = HR * SV = 70 beats/min * 80mL = 5600mL/min = 5,6 L/min
I. Cardiac output
2. How to calculate cardiac output (give the values as well)?
- CO = 5,6 L/min at rest
- CO = HR * SV = 70 beats/min * 80mL = 5600mL/min = 5,6 L/min
II. Total peripheral resistance (TPR)
1. Definition of Total peripheral resistance (TPR)
The ratio of arteriovenous pressure difference to the flow through the entire systemic vascular bed (essentially the CO)
II. Total peripheral resistance (TPR)
2. Formula of Total peripheral resistance (TPR)
The ratio of arteriovenous pressure difference to the flow through the entire systemic vascular bed
(essentially the CO)
=> MABP = CO * TPR
III. Stroke volume
1. What is Stroke volume?
SV = amount of blood transported to aorta during systole
III. Stroke volume
2. How to calculate the stroke volume?
The difference between the volume of blood in the ventricle before ejection (end diastolic volume) and the volume remaining in the ventricle after ejection (end systolic volume)
SV = EDV - ESV
- Less than half of the blood volume remains in the ventricles
- Stroke volume (SV) = EDV – ESV = 140mL – 60mL = 80mL
IV. Eject fraction (EF)
1. Definition of Eject fraction (EF)
A measure of how much blood the left ventricle pumps out with each contraction in percentage
- Refers to how well the left ventricle pumps blood with each beat
IV. Eject fraction (EF)
2. How to calculate Eject fraction (EF)
- 0,5 < EF < 0,75 -> more than 1⁄2, but less than 3⁄4 of volume should be ejected
- 0,50 < EF < 0,75 ↔ 1⁄2 < EV <3⁄4
V. 4 factors that determine the CO
1. What are the 4 factors that determine CO?
- Cardiac factors
a) Heart rate
b) Myocardial contractility - Coupling factors (heart + circulation)
a) Preload
b) Afterload
V. 4 factors that determine the CO
2. Definition of cardiac factors
Cardiac factors: strictly cardiac factor, but influenced by hormonal + neural factors
a) Heart rate
b) Myocardial contractility
V. 4 factors that determine the CO
2B. What are characteristics of Myocardial contractility (a cardiac factor)
Myocardial contractility: ability of heart to increase contraction force
- Influenced by SYM activity
- Determines the SV + HR = CO
V. 4 factors that determine the CO
3A. Definition of the coupling factors?
Coupling factors (heart + circulation) – constitute a functional coupling of heart + vessels
a) Preload
b) After load
V. 4 factors that determine the CO - the coupling factors
3B. What is preload?
Preload: force that stretches the relaxed muscle fibers = (blood filling the wall during diastole)
V. 4 factors that determine the CO - the coupling factors
3C. What is afterload?
Afterload: force added to the muscle against which the contracting muscle must act = aortic pressure (left ventricle must generate a greater pressure than the aorta to open the valve)
VI. Regulation of cardiac output
1. What are the 2 types of regulations?
- Heterometric regulation
- Homometric regulation