CC pt 4

Question 1

What are the steps for cough therapy

Answer 1

-isolated bothersome symptom
-consider non-medical measures
-consider CC product (1-2 ingredients)
-Consider precautions of use and modify

Question 2

What are some non-drug measures

Answer 2

soup (expectorate), rest, fluid, propping up (drain nose)
Saline gargles: do until taste salt, for throat not congestion
Nose drops, irrigation
Suction bulb: best to plug other nostril to get suction

Question 3

What is the benefit of saline (salinex). What does child look like that would benefit

Answer 3

Loosens in nose, helps with congestion
Clear and runny snot fine, darker and thicker may need saline to help remove

Question 4

Compare Rhinaris mist vs gel

Answer 4

Gel: not good for kids, more for adult with dry nose
Mist: better for child, somewhat placebo but way to provide releif

Question 5

What are sinus rinses effective for

Answer 5

Allergic rhinitis > chronic sinus > colds
-loosen congestion and temporary relief, doesn’t help with pain, don’t work like decongestant

Question 6

How effective are breathe right strips

Answer 6

Don’t greatly increase airflow or help with snoring. Doesn’t relieve congestion

Question 7

What is the benefit of Methyl Camphor product

Answer 7

Vapo inhaler. Provides cooling effect instead of decongestant, air going in is cooler

Question 8

How does early defence cold virus blocker work

Answer 8

Is a potential barrier to catch viruses, but needs to be used at very frequent rate

Question 9

How does aromatic cpds decongestant work. examples

Answer 9

Acts on cool receptors in the nose, topical.
Kids get smaller amount. Is rubbed on chest and fumes provide relief (TLC)
eg)vicks vapo or baby rub

Question 10

Mechanism of Action for decongestant

Answer 10

Noardrenalin-mediated decongestion. direct (alpha receptors) vs indirect acting (synaptic cleft)
-adrenaline interacts with alpha receptors, acts on blood vessels which cause them to shrink. Less pressure in tissues and can breathe better
-direct acting: Kicks out more adrelaine to hit blood vessels
-s/e = goes over many parts of body

Question 11

What are oral and topical agents of decongestants. What for do different ages use

Answer 11

Oral: pseudoephedrine (PSE) and phenyleprine (pe)
Topical: xylometazoline (q8-10hr) and oxymetazoline (q12hr)

less than 6: drops
Over 6: sprays

Question 12

Give examples of oxymetazoline, xylometazoline

Answer 12

oxy: dristan
Otrivin: xylo. has moisturizers which can confuse people to think they’re like saline.

Question 13

What is the change with Sudafed

Answer 13

Change from pseudoephedrine to phenylephrine. Can no longer make into meth so is available OTC.
-best oral decongestant

Question 14

What are absorbance differences of sudafed PE (pe) and sudafed (pse)

Answer 14

PE: more inconsistant agent, bioF is variable
pse: bioF more consistant

Question 15

How to choose between oral and topical

Answer 15

Preference, onset (topical mins, oral hours), congestion and other symptoms (oral covers multiple), Side effects/CIs

Question 15

s/e of oral decongestants

Answer 15

CNS effects: stimulant, makes harder to sleep at night
Cardiovascular: increase HR and BP and alters by couple points.
Increase blood glucose: Concern for type 1, is monitored more and can catch. Almost zero impact on type 2 [like adding twig to fire, not much effect]
Hyperthyroidism: to much is bad, get surgical therapy
Glaucoma: high bp, drainage state falters and pressure in eye increases
Uriniary: prostate gets larger and harder to stop and start

Question 16

How did coricidin make safe oral decongestant for those with hyper tension

Answer 16

Removed the decongestant, not much affects for symptoms

Question 17

What type of agonist are decongestants

Answer 17

Alpha. Work to relax prostate
AAA: orally to relax, block removes tension. Reverse AAA usage

Question 18

What are some oral decongestant drug interactions

Answer 18

SSRIs: block inhibitor, not a large problem

MAOI: NE increases in synaptic cleft and can’t decay, created drug induced high tension environment. Inactivates cpds. More gets absorbed in the gut

pseudoephedrin and zoloft have no interaction

Question 19

Topical agents s/e

Answer 19

Angle closure glaucoma
-rare, in nose, may dilate eye
Rebound Congestion
-up to 12 hours working for 3 days, allergies use beyond 3 days. Blood vessels little more dialated, enough useage very rebounded and cause congestion

Question 20

Phenylephrine vs xylometazoline useage

Answer 20

pe: 3 days, usa only
xylo: 7 days use

Question 21

What is pediatric usage for decongestants

Answer 21

No pediatric version, push for regualr nasal saline

Question 22

What is pediatric usage for decongestants

Answer 22

No pediatric version, push for regualr nasal saline