CC pt 4 Flashcards
What are the steps for cough therapy
-isolated bothersome symptom
-consider non-medical measures
-consider CC product (1-2 ingredients)
-Consider precautions of use and modify
What are some non-drug measures
soup (expectorate), rest, fluid, propping up (drain nose)
Saline gargles: do until taste salt, for throat not congestion
Nose drops, irrigation
Suction bulb: best to plug other nostril to get suction
What is the benefit of saline (salinex). What does child look like that would benefit
Loosens in nose, helps with congestion
Clear and runny snot fine, darker and thicker may need saline to help remove
Compare Rhinaris mist vs gel
Gel: not good for kids, more for adult with dry nose
Mist: better for child, somewhat placebo but way to provide releif
What are sinus rinses effective for
Allergic rhinitis > chronic sinus > colds
-loosen congestion and temporary relief, doesn’t help with pain, don’t work like decongestant
How effective are breathe right strips
Don’t greatly increase airflow or help with snoring. Doesn’t relieve congestion
What is the benefit of Methyl Camphor product
Vapo inhaler. Provides cooling effect instead of decongestant, air going in is cooler
How does early defence cold virus blocker work
Is a potential barrier to catch viruses, but needs to be used at very frequent rate
How does aromatic cpds decongestant work. examples
Acts on cool receptors in the nose, topical.
Kids get smaller amount. Is rubbed on chest and fumes provide relief (TLC)
eg)vicks vapo or baby rub
Mechanism of Action for decongestant
Noardrenalin-mediated decongestion. direct (alpha receptors) vs indirect acting (synaptic cleft)
-adrenaline interacts with alpha receptors, acts on blood vessels which cause them to shrink. Less pressure in tissues and can breathe better
-direct acting: Kicks out more adrelaine to hit blood vessels
-s/e = goes over many parts of body
What are oral and topical agents of decongestants. What for do different ages use
Oral: pseudoephedrine (PSE) and phenyleprine (pe)
Topical: xylometazoline (q8-10hr) and oxymetazoline (q12hr)
less than 6: drops
Over 6: sprays
Give examples of oxymetazoline, xylometazoline
oxy: dristan
Otrivin: xylo. has moisturizers which can confuse people to think they’re like saline.
What is the change with Sudafed
Change from pseudoephedrine to phenylephrine. Can no longer make into meth so is available OTC.
-best oral decongestant
What are absorbance differences of sudafed PE (pe) and sudafed (pse)
PE: more inconsistant agent, bioF is variable
pse: bioF more consistant
How to choose between oral and topical
Preference, onset (topical mins, oral hours), congestion and other symptoms (oral covers multiple), Side effects/CIs
s/e of oral decongestants
CNS effects: stimulant, makes harder to sleep at night
Cardiovascular: increase HR and BP and alters by couple points.
Increase blood glucose: Concern for type 1, is monitored more and can catch. Almost zero impact on type 2 [like adding twig to fire, not much effect]
Hyperthyroidism: to much is bad, get surgical therapy
Glaucoma: high bp, drainage state falters and pressure in eye increases
Uriniary: prostate gets larger and harder to stop and start
How did coricidin make safe oral decongestant for those with hyper tension
Removed the decongestant, not much affects for symptoms
What type of agonist are decongestants
Alpha. Work to relax prostate
AAA: orally to relax, block removes tension. Reverse AAA usage
What are some oral decongestant drug interactions
SSRIs: block inhibitor, not a large problem
MAOI: NE increases in synaptic cleft and can’t decay, created drug induced high tension environment. Inactivates cpds. More gets absorbed in the gut
pseudoephedrin and zoloft have no interaction
Topical agents s/e
Angle closure glaucoma
-rare, in nose, may dilate eye
Rebound Congestion
-up to 12 hours working for 3 days, allergies use beyond 3 days. Blood vessels little more dialated, enough useage very rebounded and cause congestion
Phenylephrine vs xylometazoline useage
pe: 3 days, usa only
xylo: 7 days use
What is pediatric usage for decongestants
No pediatric version, push for regualr nasal saline
What is pediatric usage for decongestants
No pediatric version, push for regualr nasal saline
