Cardiology - Rheumatic Fever Flashcards
Definition
2-4 week pharyngeal infection with group A - β-haemolytic Streptococcus pyogenes.
Rheumatic heart disease usually occurs after recurrent episodes.
Epidemiology
Childhood and adolescence : peak age 5-17 years old
Developing world
Malnutrition
Overcrowding
Family history of rheumatic fever
HLA class II
Signs
Heart murmur: strongly associated with mitral stenosis (chronic) and regurgitation (acute) and aortic regurgitation
Tender joints: usually not swollen
Palpitations
Erythema marginatum: pink or red macules (flat) and papules (raised) with a clear centre on the trunk or limbs
Subcutaneous nodules
Symptoms
- Recent sore throat or scarlet fever: occurs 2-4 weeks before chest pain
- Chest pain: pleuritic
- SOB
- Fever and rigours
- Joint pain: oligo- or poly- arthritis
= severe pain
= often involves the lower limbs - Non-pleuritic rash
- Syndenhams chorea
= rapid, uncoordinated jerking movement of the face, hand and feet
= occurs up to 6 months after initial infection
Criteria
JONES CRITERIA: 2 major criteria or 1 major and 2 minor criteria
- Evidence of recent strep infection:
= rapid group A streptococcal antigen test: positive
= throat culture: positive
= recent scarlet fever
- Major criteria
= carditis: pericarditis with the endocardium most typically affected, Px may have a new murmur +/or HF
= arthritis: migratory polyarthritis MC larger joints
= erythema marginatum
= Sydenham’s chorea
= subcutaneous nodules
Minor criteria
= Pyrexia
= inflammatory markers: raised ESR or CRP
= arthralgia
= ECG: prolonged PR interval due to risk of heart block
= previous rheumatic fever
Diagnosis
Chest X ray: cardiomegaly + CHF
Echo: aortic valvular pathology, pericarditis or pericardial effusion
Blood cultures: if Px pyrexial
Treatment
Conservative: bed rest, analgesia, immobilise joints in severe arthritis
Antibiotics: BENZYLPENICILLIN IV STAT, followed by oral PHENOXYMETHYLPENICILLIN for 10 days
Severe Syndenham’s chorea: HALOPERIDOL
Secondary prophylaxis
Long term, regular Abx = IM benzylpenicillin
Duration dependant on Px factors:
- No carditis or rheumatic heart disease = min 5 years after attack or until 18 years old (which ever is longer)
- Documented carditis or RHD = min 10 years after attack or until 21 years old (which ever longer)
- Moderate to severe valvular disease = LIFE
- Chronic carditis = LIFE
- Artificial valves = LIFE A
Complications
Rheumatic heart disease = 30-50% of patients mc affecting mitral valve, 2nd mc aortic valve
- mc cause of mitral stenosis
Heart failure = chronic or recurrent cases
Infective endocarditis
Atrial fibrillation