Bone Drugs

Question 1

Tetracycline does what to bone?

Answer 1

fluoresces under UV light

Question 2

what is imbedded in osteoid?

Answer 2

collagen
cytokines
growth factors

Question 3

how much trebecular vs. cortical bone remodelled per year in adults in %?

Answer 3

25% trebecular

3% cortical

Question 4

4 factors of bone remodelling

Answer 4

1. ageing
2. exercise/loading
3. hormones (estrogen)
4. drugs (corticosteroids)

Question 5

which male group has high risk for osteoporosis??

Answer 5

Asthmatics due to prolonged corticosteroid use

Question 6

2 kinds of drugs used in bone disorders:

Answer 6

1. antiresorptives

2. bone anabolics

Question 7

Bisphosphonates do what?

Answer 7

incorporated into bone over long period of time, like land mine for osteoclasts

Question 8

risk of Bisphosphonates?

Answer 8

oesophageal cancer
fractures
osteonecrosis of jaw

Question 9

Oestrogen does what to bone?

Answer 9

maintains mass, slows bone loss

Question 10

Oestrogen therapy risk of?

Answer 10

CVD

breast Ca

Question 11

What are SERMs? example?

Answer 11

replaced HRTs
Selective eostrogen receptor modulators
Eg. Raloxifene

Question 12

Raloxifene agonist where? antagonist where?

Answer 12

Agonist: bone and CV tissue
Antagonist: mammary and uterus

Question 13

What is Denosumab?

Answer 13

RANKL inhibitor (reduce osteoclast activity)
Human Monoclonal antibody

Question 14

why does PTH have paradoxical behaviour?

Answer 14

acutely: promotes osteoblast

Chronic high: promotes osteoclasts

Question 15

2 kinds of oral calcium?

Answer 15

Calcium gluconate

Calcium lactate

Question 16

Vitamin D given as what form?

Answer 16

D2 and/or D3

Calcitriol

Question 17

synthetic calcitonin?

Answer 17

salcatonin

Question 18

Calcitonin admin?

Answer 18

S/C or I/M

Question 19

When use calcitonin?

Answer 19

hypercalcaemia associated with neoplasia