Body Systems L20 Flashcards
Describe what gases are transported from which systems / organs in the blood. (Major 2 paths)
• Transportation of Gas:
- O2 -> Alveoli to systemic tissues
- CO2 -> Systemic tissues to alveoli
Via Transportation -> Blood.
Describe the features required for efficient gas exchange in the blood
• Gas Transportation -> Blood: - Diffusion Surface area >> Large >> Moist Diffusion distance >> Short Conc. gradient / Diff. -> Partial pressure >> Alveolar air & blood Solubility of gases Coordination -> Blood & Air flow
What are the partial pressures of N2 in the lungs alveoli & pulmonary veins?
- Atmosphere N2 -> 78.6% -> 597mmHg - Alveoli N2 -> 75.4% -> 573mmHg - Pulmonary Veins N2 -> 12.5 ml/L
What are the partial pressures of O2 in the lungs alveoli & pulmonary veins?
- Atmosphere O2 -> 20.9% -> 159mmHg - Alveoli O2 -> 13.2% -> 100mmHg - Pulmonary Veins O2 -> 3 ml/L
What are the partial pressures of CO2 in the lungs alveoli & pulmonary veins?
- Atmosphere CO2 -> 0.04% -> 0.3mmHg - Alveoli CO2 -> 5.2% -> 40mmHg - Pulmonary Veins CO2 -> 26 ml/L
What is the partial pressures of water in the atmoshpere vs. the alveoli of the lungs?
Atmoshpere
H2O -> 0.46% -> 3.7mmHg
Alveoli
H2O -> 6.2% -> 47mmHg
What is Dalton’s Law?
• Dalton’s Law of Partial Pressure:
Total pressure exerted by mixture of gases = Sum of pressures exerted independently by each gas in mixture.
What is the partial pressure (Dalton’s Law)
Partial pressure
Pressure exerted by each gas
Directly proportional to % in total gas mixture
Eg. Partial pressure of O2 -> Sea Level
»_space; 20.9% of gases at sea level
»_space; Atmospheric pressure = 760mmHg
-» 20.9 x 760 = 159mmHg (Partial Pressure)
Describe the relationship between atmospheric pressure & altitude
• Atmospheric pressure decr. with incr. altitude above sea level.
What are the partial pressures found in the capillaries & alveoli in the pulmonary circuit?
- Pulmonary Circuit: >> External Respiration Capillary: P(O2) = 40 P(CO2) = 45 Alveolus: P(O2) = 100 P(CO2) = 40 Capillary : P(O2) = 100 P(CO2) = 40
What are the partial pressures found in the capillaries & alveoli in the systemic circuit?
- Systemic Circuit: >> Internal Respiration Capillary: P(O2) = 95 P(CO2) = 40 Tissues: P(O2) = 40 P(CO2) = 45 Capillary : P(O2) = 40 P(CO2) = 45
What is Henry’s Law?
• Henry’s Law:
- The amount of gas that dissolves in water determined by
Solubility in water
Partial pressure in air
Describe the conditions of equilibrium of Henry’s Law
- At equilibrium:
Vol. -> Dissolved gas in solution proportional to partial pressure of gas.
Eg. Incr. P(Gas) -> Incr. # gas molecules in solution
Incr. P(O2) -> Incr. amount of O2 in solution.
Outline the gas diffusion requirements of the human body
• Gas Diffusion Requirements: - At alveolar P(O2) -> (100mmHg) 1L plasma dissolves 3ml O2 Blood Flow -> Tissues = 5 L/min >> 15 ml/min O2 - Requires >200 ml/min (200-3000 ml/min) - 1 L blood -> 195ml O2
Describe the structure of Haemoglobin
• Haemoglobin: - 4 globular protein subunits >> 2 alpha >> 2 Beta - Each subunit >> Protein -> Globin >> Non-protein group -> Haem --> Fe2+ -> Porphyrin ring
State the reaction which occurs at haemoglobin & 2 properties of this reaction
Hb + O2 HbO2
Hb -> Deoxy-haemoglobin ; HbO2 -> Oxyhaemoglobin
»_space; Rapid & reversible
How many oxygen molecules does each Hb molecule bind with?
- Each haem portion -> Haemoglobin
Binds -> 4 molecules -> O2
Describe the different ways in which oxygen is transported in the blood & the proportions of oxygen transported by these methods.
• Transportation of O2:
- Approx. 97% O2 transported in Blood -> Using Hb
- Remaining 3% O2 transported in Blood -> Plasma
Describe the uptake of O2 by haemoglobin and what this causes.
Hb changes shape upon binding with O2
»_space; Enables further uptake of O2 -> Positive Feedback
»_space; Binding of O2 mol. to Hb cause change in shape of Hb
> Enables easier successive binding of O2 to Hb.
»_space; As max. limit of O2 binding approaches, affinity decreases.
What is Hb saturation?
Hb Saturation:
% of haem units per Hb mol containing bound O2
What is Hb saturation affected by?
Affected by: >> Partial pressure O2 - > P(O2) -> Blood >> Blood pH >> Temperature >> No. of O2 mol. already bound -> haem ---> O2 dissociation Curve
What is the oxygen dissociation curve?
O2 Dissociation (Saturation) Curve
Graph illustrating Saturation of Hb in relation to P(O2) in blood
Describe the shape of the oxygen dissociation curve?
Steep portion of curve >> Range -> % saturation within systemic capillaries. > 75 – 100% saturation -->> P(O2) ~ 40mmHg >> 100% sat. of Hb within alveoli
Steep rise followed by plateau
List the factors which influence the affinity of Hb for O2?
Factors influencing affinity for O2:
% saturation & affinity of Hb for O2:
»_space; Increases with each successive binding of O2 to Hb
»_space; Increases with incr. P(O2)
» Partial pressure O2 - > P(O2) -> Blood
» Blood pH
» Temperature
» No. of O2 mol. already bound -> haem