Body Systems L15 Flashcards
Name types of systemic & vascular disorders
Hypertension
Atherosclerosis
Thrombosis
Describe Hypertension
• Hypertension:
Affects nearly one billion
One of the main causes -> premature death.
Nearly 8 million fatalities per year
Types:
- Primary Hypertension
(Essential / Idiopathic)
Unknown medical cause
Links:
Genetic predisposition
Alcohol consumption
Obesity
Lack of excersise
Diabetes
Intrauterine environment
- Secondary Hypertension
Known medical cause
1) Kidney Disease:
Incr. Angiotensin II
» Vasoconstriction & expansion -> cellular fluid
2) General endocrine disorders
Eg. Diabetes, Cushing’s
3) Adrenal medulla disease (Phaeochroocytoma)
Excessive adrenaline secretion
Treatment:
- Inhibit angiotensin II production -> Angiotensin-Converting-Enzyme (ACE)
» Prevents renal absorption -> Na+/H2O
> Prevents incr. blood volume
- Ibhibition -> Angiotensin II induced vasoconstriction -> Angiotensin II receptor
blocker.
»_space; Inhibitd membrane cardiac / vascular depolarizoation
> Decr. CO -> vasodilation.
- Calcium-channel blocker / thiazide diuretic
»_space; Incr. loss -> Na+ & H2O
> Decreases fluid volume, venous return & cardiac output.
- Reduce TBR -> inhibition -> noradrenaline action.
- Alpha-adrenoreceptor Antagonists (alpha-Blockers)
Reduce TBR -> inhibition -> noradrenaline action.
- Beta-adrenoreceptor Antagonists (beta-Blockers)
Decr. CO2,
Decr. central activity -> Symapthetic nervous system
Decr. release -> Renin
-» Favourable secondary actions
Risks:
- Atherosclerosis
- Stroke / Cerebrovascular Accident
- Heart Failure
- Renal Failure
- Aneurysms
What are the figures regarding those affected by hypertension
Affects nearly one billion
One of the main causes -> premature death.
Nearly 8 million fatalities per year
Name the types of hypertension
Primary
Secondary
Describe primary hypertension & the main links associated with it
- Primary Hypertension (Essential / Idiopathic) Unknown medical cause Links: Genetic predisposition Alcohol consumption Obesity Lack of excersise Diabetes Intrauterine environment
Describe secondary Hypertension & the main known causes
- Secondary Hypertension Known medical cause 1) Kidney Disease: Incr. Angiotensin II >> Vasoconstriction & expansion -> cellular fluid 2) General endocrine disorders Eg. Diabetes, Cushing’s 3) Adrenal medulla disease (Phaeochroocytoma) Excessive adrenaline secretion
What are the types of secondary hypertension & what do they cause?
1) Kidney Disease:
Incr. Angiotensin II
» Vasoconstriction & expansion -> cellular fluid
2) General endocrine disorders
Eg. Diabetes, Cushing’s
3) Adrenal medulla disease (Phaeochroocytoma)
Excessive adrenaline secretion
What does kidney disease in relation to hypertension cause?
1) Kidney Disease:
Incr. Angiotensin II
» Vasoconstriction & expansion -> cellular fluid
What does General endocrine disorders in relation to hypertension cause?
2) General endocrine disorders
Eg. Diabetes, Cushing’s
What does Adrenal medulla disease in relation to hypertension cause?
3) Adrenal medulla disease (Phaeochroocytoma)
Excessive adrenaline secretion
Describe the treatment methods for Hypertension
Treatment:
- Inhibit angiotensin II production -> Angiotensin-Converting-Enzyme (ACE)
» Prevents renal absorption -> Na+/H2O
> Prevents incr. blood volume
- Ibhibition -> Angiotensin II induced vasoconstriction -> Angiotensin II receptor
blocker.
»_space; Inhibitd membrane cardiac / vascular depolarizoation
> Decr. CO -> vasodilation.
- Calcium-channel blocker / thiazide diuretic
»_space; Incr. loss -> Na+ & H2O
> Decreases fluid volume, venous return & cardiac output.
- Reduce TBR -> inhibition -> noradrenaline action.
- Alpha-adrenoreceptor Antagonists (alpha-Blockers)
Reduce TBR -> inhibition -> noradrenaline action.
- Beta-adrenoreceptor Antagonists (beta-Blockers)
Decr. CO2,
Decr. central activity -> Symapthetic nervous system
Decr. release -> Renin
-» Favourable secondary actions
Outline the methods used to treat hypertensin
- Inhibit angiotensin II production
- Inhibit angiotensin II production
- Calcium-channel blocker / thiazide diuretic
- Reduce TBR -> inhibition -> noradrenaline action.
- Alpha-adrenoreceptor Antagonists
Beta-adrenoreceptor Antagonists
Describe how angiotensin II production is prevented in treatment of hypertension
- Inhibit angiotensin II production -> Angiotensin-Converting-Enzyme (ACE)
» Prevents renal absorption -> Na+/H2O
> Prevents incr. blood volume
Describe how angiotensin II induced vasoconstriction is inhibited in treatment of hypertension
Ibhibition -> Angiotensin II induced vasoconstriction -> Angiotensin II receptor
blocker.
»_space; Inhibitd membrane cardiac / vascular depolarizoation
> Decr. CO -> vasodilation.
Describe how - Calcium-channel blocker / thiazide diuretic is used in treatment of hypertension
- Calcium-channel blocker / thiazide diuretic
»_space; Incr. loss -> Na+ & H2O
> Decreases fluid volume, venous return & cardiac output.
Describe how Alpha-adrenoreceptor Antagonists are used in treatment of hypertension
- Alpha-adrenoreceptor Antagonists (alpha-Blockers)
Reduce TBR -> inhibition -> noradrenaline action.
Describe how Beta-adrenoreceptor Antagonists are used in treatment of hypertension
- Beta-adrenoreceptor Antagonists (beta-Blockers)
Decr. CO2,
Decr. central activity -> Symapthetic nervous system
Decr. release -> Renin
-» Favourable secondary actions
Describe the risks associated with hypertension
Risks:
- Atherosclerosis
- Stroke / Cerebrovascular Accident
- Heart Failure
- Renal Failure
- Aneurysms
Describe Atherosclerosis
• Atherosclerosis:
Narrowing of vessel lumen:
Fibrous cap of dense extracellular matrix
Accumulation -> Plaque Formation:
Lipids
Macrophages
Proinflammatory mediators
White blood cells
Endothelial cells
Smooth muscle cells
»_space; Arterial remodelling & neovessels occur -> compensatory enlargement
»_space;Fragments of plaques can detach & lodge in small vessels
> Cause thrombosis
-» Restricts blood flow
> Lead to aneurysm formation & rupture
What is Atherosclerosis?
Narrowing of vessel lumen:
Fibrous cap of dense extracellular matrix
Accumulation -> Plaque Formation:
How is plaque formed in Atherosclerosis?
Accumulation -> Plaque Formation: Lipids Macrophages Proinflammatory mediators White blood cells Endothelial cells Smooth muscle cells
What does plaque formation cause in Atherosclerosis?
> > Arterial remodelling & neovessels occur -> compensatory enlargement
»_space;Fragments of plaques can detach & lodge in small vessels
> Cause thrombosis
-» Restricts blood flow
> Lead to aneurysm formation & rupture
Describe thrombosis
• Thrombosis: Formation of blood clot in vein - Most common -> Deep Vein Thrombosis (DVP) -> legs - Pulmonary Embolism (PE) -> Lungs >> Swelling, Skin changes
What is thrombosis?
Formation of blood clot in vein
Where is thrombosis commonly found?
- Most common -> Deep Vein Thrombosis (DVP) -> legs
- Pulmonary Embolism (PE) -> Lungs
What does thrombosis cause?
> > Swelling, Skin changes
Name major diseases of the heart
- Ischaemic Heart Disease (Coranary Heart Disease -> CAD)
- Valve defects:
- Arrhythmias:
- Chronic Heart Failure:
- Aortic Disease:
Describe • Ischaemic Heart Disease (Coranary Heart Disease -> CAD)
• Ischaemic Heart Disease (Coranary Heart Disease -> CAD)
Leading cause of death -> Developed world
30% Males
23% Females
Common cause:
Atherosclerosis -> coronary artery
Most frequent -> Left anterior interventricular artery
Affects Left ventricle
Occurs
Insufficient Blood flow to myocardium
» Angina Pectoris (ischemia-induced pain)
-»Mediated by endogeneous vasodilators
» Results -> myocardial infarction
-» Death of heart muscle within 20 mins
How much of the population does • Ischaemic Heart Disease (Coranary Heart Disease -> CAD) affect?
Leading cause of death -> Developed world
30% Males
23% Females
What are common causes of • Ischaemic Heart Disease (Coranary Heart Disease -> CAD)?
Atherosclerosis -> coronary artery
Most frequent -> Left anterior interventricular artery
Occurs in Left ventricle
Insufficient Blood flow to myocardium
» Angina Pectoris (ischemia-induced pain)
-»Mediated by endogeneous vasodilators
» Results -> myocardial infarction
-» Death of heart muscle within 20 mins
Describe Valve defects of the heart
• Valve defects: 1. Regurgitation Inadequate closure >> Backflow of blood > Causes Turbulence ->> Followed -> Decr. cardiac output 2. Stenosis Inadequate opening >> Obstructs blood flow > Causes thickening of valve, papillary muscle / chordae tendiane (following disease) Eg. Rheumatic fever -> mitral valve stenosis up to 20yrs after infection.
What are the two types of valve defect of the heart?
- Regurgitation
2. Stenosis
Describe regurgitation valve defects of the heart
1. Regurgitation Inadequate closure >> Backflow of blood > Causes Turbulence ->> Followed -> Decr. cardiac output
Describe stenosis valve defects of the heart
- Stenosis
Inadequate opening
» Obstructs blood flow
> Causes thickening of valve, papillary muscle / chordae tendiane
(following disease)
Eg. Rheumatic fever -> mitral valve stenosis up to 20yrs after infection.
Describe arrhythmias
• Arrhythmias:
Deviation of heart’s normal sinus (SAN) rhythm.
Relatively rare
-> 1 in 5000-10000
Found -> young individuals ; <25yrs
Many arise
-> Defects in ion channels regulating ventricular action potentials
Cause spontaneous multiple depolarizations
»_space; Ventricular arrythmias
Produce sustained abnormal rhythm
Asymptomatic
Palpitations
Dizziness
Syncope
Heart Failure
Sudden Death
1. Bradycarida:
Slow Rhythm (<60bpm)
Causes:
Slowed signal -> sinus bradycardia
Pause / sinus arrest
Blockage
»_space; Due to SAN / conducting tissue damage
Treatment:
Artificial pacemaker
- Tachycardia:
Fast Rhythm (>100bpm)
Sinus Tachycardia
Innapropriate Sinus Tachycardia (IST)
Invlolves:
» Caffeine
» Amphetamines
» Overactive thyroid gland -> SNS
Non-sinus Tachycardia
-> Addition of abnormal inpulses -> normal cycle
> Uncontrolled twitching / quivering -> muscle fibres (fibrils)
> Blood not removed from heart -> ventricular fibrillation
> Sudden cardiac death
Caused by:
» Automaticicity (enhanced pacemaker)
» Triggered Beats (Early / delayed depolarization)
» Re-entry Activity / Circus Activity (Conduction profile defects)
» Conduction Block
»Heart Damage
Pathology: >> Congenital Heart Disease >> Elecrocution Accidents >> Heart Injury >> Cardiomyopathies >> Heart Surgery >> Ischamia
Ectopic Action potential initiated in cardiac myocyte > Can lead to (mainly harmless) single premature beat SNS & hypoxia incr, automaticity.
Describe the characteristics of heart arrhythmias
• Arrhythmias:
Deviation of heart’s normal sinus (SAN) rhythm.
Relatively rare
-> 1 in 5000-10000
Found -> young individuals ; <25yrs
Many arise
-> Defects in ion channels regulating ventricular action potentials
Cause spontaneous multiple depolarizations
»_space; Ventricular arrythmias
Produce sustained abnormal rhythm
Describe some of the symptoms associated with arrhythmias
Asymptomatic Palpitations Dizziness Syncope Heart Failure Sudden Death
Describe the general way in which most arrhythmias arise
Many arise
-> Defects in ion channels regulating ventricular action potentials
Cause spontaneous multiple depolarizations
»_space; Ventricular arrythmias
Produce sustained abnormal rhythm
Describe bradycardia
1. Bradycarida: Slow Rhythm (<60bpm) Causes: Slowed signal -> sinus bradycardia Pause / sinus arrest Blockage >> Due to SAN / conducting tissue damage Treatment: Artificial pacemaker
What is bradycardia?
Heart arrhythmia -> slow rhythm (<60bpm)
What is tachycardia?
Heart arrhythmia -> Fast Rhythm (>100bpm)
What are the causes of bradycardia?
Causes: Slowed signal -> sinus bradycardia Pause / sinus arrest Blockage >> Due to SAN / conducting tissue damage
How is bradycardia treated?
Treatment:
Artificial pacemaker
Name the types of tachycardia
- Sinus Tachycardia
Innapropriate Sinus Tachycardia (IST) - Non-sinus Tachycardia
Describe Sinus Tachycardia & what it involves
Sinus Tachycardia Innapropriate Sinus Tachycardia (IST) Invlolves: >> Caffeine >> Amphetamines >> Overactive thyroid gland -> SNS
Describe Non-sinus Tachycardia
Non-sinus Tachycardia
-> Addition of abnormal inpulses -> normal cycle
> Uncontrolled twitching / quivering -> muscle fibres (fibrils)
> Blood not removed from heart -> ventricular fibrillation
> Sudden cardiac death
Caused by:
» Automaticicity (enhanced pacemaker)
» Triggered Beats (Early / delayed depolarization)
» Re-entry Activity / Circus Activity (Conduction profile defects)
» Conduction Block
»Heart Damage
Pathology: >> Congenital Heart Disease >> Elecrocution Accidents >> Heart Injury >> Cardiomyopathies >> Heart Surgery >> Ischamia
Ectopic Action potential initiated in cardiac myocyte > Can lead to (mainly harmless) single premature beat SNS & hypoxia incr, automaticity.
What are the characteristics of Non-sinus tachycardia?
Non-sinus Tachycardia
-> Addition of abnormal inpulses -> normal cycle
> Uncontrolled twitching / quivering -> muscle fibres (fibrils)
> Blood not removed from heart -> ventricular fibrillation
> Sudden cardiac death
What internal processes of the body is Non-sinus Tachycardia caused by?
Caused by:
» Automaticicity (enhanced pacemaker)
» Triggered Beats (Early / delayed depolarization)
» Re-entry Activity / Circus Activity (Conduction profile defects)
» Conduction Block
»Heart Damage
What are pathological causes of arrhythmias
Pathology: >> Congenital Heart Disease >> Elecrocution Accidents >> Heart Injury >> Cardiomyopathies >> Heart Surgery >> Ischamia
What does ectopic mean, and what can it cause?
Ectopic
Action potential initiated in cardiac myocyte
> Can lead to (mainly harmless) single premature beat
SNS & hypoxia incr, automaticity.
Describe Chronic Heart Failure
• Chronic Heart Failure:
Inadequate cardiac output
-> Despite venous return
Due to:
Decline in contractility
Inability to develop forceful contracture
Diastole:
> Inability to fill
-> Stiff, thick chambers
Systole:
> Inability to contract
-> Stretched, thin chambers
Caused by:
> Muscle damage Eg. CAD
> Additional work of heart Eg. Hypertension
> Valve defects
Causes:
> Breathlessness & fatigue
> Left Ventricular Failure:
-> Fluid accumulation -> lungs due to congestion of veins in lungs
> Right Ventricular Failure:
-> Fluid accumulation -> especially in tissues of legs & abdominal organs due
to incr. systemic capillary pressure.
What is Chronic heart failure?
• Chronic Heart Failure:
Inadequate cardiac output
-> Despite venous return
What cardiac issues lead to chronic heart failure?
Due to:
Decline in contractility
Inability to develop forceful contracture
Describe diastole & systole of the heart during Chronic Heart Failure
Diastole:
> Inability to fill
-> Stiff, thick chambers
Insufficient blood causes overworking of heart
»_space; Leads to stretching of heart muscle over time
Stretched thin chambers -> insufficient generation of force on contraction
Systole:
> Inability to contract
-> Stretched, thin chambers
What is chronic heart failure caused by?
Caused by:
> Muscle damage Eg. CAD
> Additional work of heart Eg. Hypertension
> Valve defects
What is caused as a result of chronic heart failure?
Causes:
> Breathlessness & fatigue
> Left Ventricular Failure:
-> Fluid accumulation -> lungs due to congestion of veins in lungs
> Right Ventricular Failure:
-> Fluid accumulation -> especially in tissues of legs & abdominal organs due
to incr. systemic capillary pressure.
Describe why left ventricular failure occurs
> Left Ventricular Failure:
-> Fluid accumulation -> lungs due to congestion of veins in lungs
Describe why right ventricular failure occurs
> Right Ventricular Failure:
-> Fluid accumulation -> especially in tissues of legs & abdominal organs due
to incr. systemic capillary pressure.
What does digitalis glycosides cause in relation to the heart?
• Digitalis Glycosides
> Incr. force of contraction
> Decreased vagal conduction
Describe aortic disease
• Aortic Disease:
Aortic aneurysm
Weakening of aortal wall
» Bulges outwards
How does a stroke occur?
• Stroke:
Occurs as result of blockage -> blood supply to part of brain.
Describe the cause of coronary heart disease?
• Coronary Heart Disease:
Reduced flow / Blockage -> Oxygen rich blood to heart
» Atheroma (fatty material) accumulation -> coronary arteries
What is a common symptom of peripheral arterial disease?
• Peripheral arterial disease:
Common symptom -> leg pain while walking.