BMS13 Flashcards
Describe the ion channels in the colon (5)
Left side
Na in
H out and Na in
HCO3 out and Cl in
Right side
Na out and K in using ATP
Cl out
What may cause malabsorption? (4)
Bile salts not circulating properly, failure of pancreatic enzyme delivery, lack of vitamins or too much water being retained
What takes bile back to the liver?
Portal vein
Describe a villi (5)
Goblet cells, ion channels and enterocytes line it
Lacteals and capillaries are in the centre
Intestinal crypts
What happens in intestinal crypts?
Stem cells move up and differentiate
What does lipase do?
Cut 2 FA from TAG
What do lacteals do?
Absorb fat in the form of chylomicrons
What do enterocytes do?
Make enzymes e.g. enterokinase
What happens to lipids?
Lipoprotein B packages lipids into chylomicrons which the lipids absorb
What does bile do and where does the end of the journey come?
Emulsify lipids so they form micelles which contain bile salt and lipases so they can be cut up and diffuse into enterocytes
What happens when FA diffuse into enterocytes?
SER resynthesizes them
Where does protein digestion start and finish?
In the stomach with HCl and pepsin and then to the duodenum
What does enterokinase do?
Convert inactive enzymes into their active form e.g. tripsinogen to trypsin
What does trypsin do?
Activate inactive enzymes
What makes intrinsic factor for B12?
Parietal cells
What stimulates water absorption in the colon?
Aldosterone
What is the importance of microflora?
It can’t cross the epithelium which helps make vit K and folic acid
What may cause not enough water absorption?
Bacterial infections
Where is the main site of water absorption?
Small intestine
What pumps does the small intestine have?
Fructuose, Na/glucose, Na/K/ATP and then Glucose/Fructose
Describe the tissue of the oesophagus (3)
Smooth & skeletal muscle
connective tissue makes the adventitia
Non-keratinized stratified squamous epithelium makes the mucosa
How many sphincters does the oesophagus have?
2
What do parotid glands excrete?
Serous
What do submandibular glands excrete?
Serous and mucosal
What do sublingual glands excrete?
Mucosal
What shuts the stomach off from the duodenum?
Pyloric sphincter
What does the large intestine do?
Absorbs water and vitamins to finish digestion
What does CKK cause?
Contract the gall bladder and relax the sphincter