BMS02 Flashcards
What is the nernst equation?
58 x log x (conc out / conc in)
What is the Goldman Hodgkin Katz equation and how is it different to the Nernst equation?
58 x log x ((50 x K out + Na out) / (50 x K in) + Na in)
It considers the permeabilities of the ions
There is 50 times more K than Na
Draw glutamine
CH2 CH2
What type of collagen makes cartilage, blood vessels, tendon, bone, skin and lungs?
Type 2 and all others are type 1
What does pKa =
When half of the acid has dissociated
What is the Henderson Hasselblach equation?
pH = pKa + log (A / HA)
What 3 organs buffer in the blood?
Blood, kidney and lungs
What are the concentrations of Na, K and Cl in and out of cells?
Na in 10 out 140
K in 140 out 4
Cl in 4 out 140
What 3 things does the SER do?
Detoxification
Recycling
Lipid metabolism
What bond binds FA to glycerol?
Ester bonds
What 3 things create fluidity in the cell membrane?
Unsaturated fats, low cholesterol content and short FA
What 4 compounds may make up a phospholipid?
Choline
Serine
Inositol
Ethanolamine
What is the Michaelis Menton equation?
Vo = Vmax x S / Km + S
What is km?
The michaelis menton constant
E + S = ES = E + P
Why is 0.5 vmax special?
Vo = 0.5 vmax when km = S
When does ROR become independent from substrate concentration?
When S is very high
What value will a competitive inhibitor alter?
Km not Vmax
What value will a non competitive inhibitor later?
Vmax not Km
What is Kcat?
The amount of product made fro
one enzyme
What is an allosteric enzyme?
It has an allosteric site for molecules to bind to to alter catalytic abilities
What is Kd?
Dissociation constant
K-1 / K1
How do you calculate the specificity constant?
Kcat / Km
Describe the lineweaver burke plot?
What occurs at the crossing of the Y and X axis
Y axis
1/Vo
1/Vmax
X axis
1/S
-1/Km
