blood and hemostasis Flashcards
what in the blood caries the most amount of O2
RBC’s
what does O2 bind to in the RBC
heme
what does OXygen concentration fall to after the capillaries
78%
of the cels in the blood, which are the only true cells
Leukocytes (RBC and platelets lack neucleus)
what are polmorphonuclear granulocytes
Neutrophils
Eosinophils
Basophils
what is the limiting factors of erythropoiesis
The availability of dietary iron
what protects from anemia when dietary iron is low
Lots of recyclining mechs
what is the storage buffer for iron
Ferritin
how long do RBC’s live
120 days
how often are RBC replaces
1% (250 billion)
what is the major breakdown product of hemoglobin
Bilirubin
how is iron recycled after RBC is destroyed
bound to transferrin and delivered to bone marrow
what happens if you are deficient in folic acid
Folic acid in needed for thymine leading to decreased cell division
what is the use of B12
required for folic acid action
what is needed to absorb B12
Intrinsic factor
what happens if you have no intrinsic factor
Prenicious anemai
what is responsible for regulation of Erythropoiesis
erythropoietin
how is Erythropoietin
Decreased O2 delivered to kidney causes the secretion
where does Erythropoietin act
activates receptors of the bone marrow
what is anemia
Decrease in the ability of the blood to carry oxygen
causes of anemai
Decreased RBC
Diminished Hemoglobin
what causes sickle cell anemai
Single amino acid genetic mutation in hemoglobin that causes hemoglobin to interact with each other under conditions of Low O2
what is the end result of sickle cell anemia
blockage capillaries
Tissue damage and pain
where does anemia manifest
homoxygous
what is the benifit of anemia
Heterozygous more resitsant to malaria
what is the precursor for RBC
Stem cells in the bone marrow
what is hemostasis
Stoppage of bleeding
what are the processes of hemostasis
Formation of a platelet plug Blood coagulation (clotting)
what blood cell is esential for hemostasis
Platelets
what is the magnet for platelts
Collagen
Action of Collagen for cogaulation
source of the signal that alters blood flow to initiate clot formation
