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physiology > blood and hemostasis > Flashcards

blood and hemostasis Flashcards

1
Q

what in the blood caries the most amount of O2

A

RBC’s

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2
Q

what does O2 bind to in the RBC

A

heme

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3
Q

what does OXygen concentration fall to after the capillaries

A

78%

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4
Q

of the cels in the blood, which are the only true cells

A

Leukocytes (RBC and platelets lack neucleus)

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5
Q

what are polmorphonuclear granulocytes

A

Neutrophils
Eosinophils
Basophils

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6
Q

what is the limiting factors of erythropoiesis

A

The availability of dietary iron

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7
Q

what protects from anemia when dietary iron is low

A

Lots of recyclining mechs

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8
Q

what is the storage buffer for iron

A

Ferritin

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9
Q

how long do RBC’s live

A

120 days

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10
Q

how often are RBC replaces

A

1% (250 billion)

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11
Q

what is the major breakdown product of hemoglobin

A

Bilirubin

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12
Q

how is iron recycled after RBC is destroyed

A

bound to transferrin and delivered to bone marrow

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13
Q

what happens if you are deficient in folic acid

A

Folic acid in needed for thymine leading to decreased cell division

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14
Q

what is the use of B12

A

required for folic acid action

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15
Q

what is needed to absorb B12

A

Intrinsic factor

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16
Q

what happens if you have no intrinsic factor

A

Prenicious anemai

17
Q

what is responsible for regulation of Erythropoiesis

A

erythropoietin

18
Q

how is Erythropoietin

A

Decreased O2 delivered to kidney causes the secretion

19
Q

where does Erythropoietin act

A

activates receptors of the bone marrow

20
Q

what is anemia

A

Decrease in the ability of the blood to carry oxygen

21
Q

causes of anemai

A

Decreased RBC

Diminished Hemoglobin

22
Q

what causes sickle cell anemai

A

Single amino acid genetic mutation in hemoglobin that causes hemoglobin to interact with each other under conditions of Low O2

23
Q

what is the end result of sickle cell anemia

A

blockage capillaries

Tissue damage and pain

24
Q

where does anemia manifest

A

homoxygous

25
Q

what is the benifit of anemia

A

Heterozygous more resitsant to malaria

26
Q

what is the precursor for RBC

A

Stem cells in the bone marrow

27
Q

what is hemostasis

A

Stoppage of bleeding

28
Q

what are the processes of hemostasis

A 
Formation of a platelet plug
Blood coagulation (clotting)
29
Q

what blood cell is esential for hemostasis

A

Platelets

30
Q

what is the magnet for platelts

A

Collagen

31
Q

Action of Collagen for cogaulation

A

source of the signal that alters blood flow to initiate clot formation

physiology (32 decks)

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