Blood And Haemopoiesis Flashcards
What are the four Humors?
Blood
Phlegm
Yellow bile
Black bile
What is the role of platelets?
Looks for small breaks in blood vessels and acts a primary plug, surface for clotting factors to make clot, repair breaks
What is Haematology?
The study and treatment of blood
What can Haemopoiesis cells do?
develop into different cell types, stimulate stem cells with different growth factors to achieve different cell types, greatest ability of self renewal, mobilise into peripheral blood, undergo apoptosis, collect from bone
What do red blood cells do?
Deliver oxygen
Why are red blood cells that shape?
Biconcave shape and lipid bilayer so flexible and no nucleus or organelles to maximise space to carry Oxygen and carbon dioxide
What are the 5 white cells?
Neutrophils Eosinophils Basophils Lymphocytes Monocytes (macrophages)
Which 4 cells are the first line killers of the innate immune system?
Neutrophils, Eosinophils, Basophils and monocytes
What do the first line killers do?
Smell organisms chemotaxis and engulfs and kills them using deadly contents of their granules
What do macrophages also do other than kill cells?
present antigen to lymphocytes
What are the two types of lymphocytes?
B cells and T cells
What do B cells do?
Produce antibodies
What do T cells do?
Recognise foreign proteins and activate other cells, directly kill and inhibit immune response
What do Natural Killer cells do?
Stimulate sick cells to self destruct (apoptosis)
What do arteriole clots predominantly include?
Platelets
What do venous clots predominantly include?
Red blood cells and fibrin
What is used in Blood transfusions?
Red blood cells, plasma and platelets
What else other than blood can be transfused?
Stem cells
What may a high blood count show?
Polycythemia, leukemia, thrombocythemia
What may a low blood count show?
Anaemia, Leucopenia, Thrombocytopenia
What do abnormal full blood count results usually show?
Mostly reactive to other conditions or treatments of these conditions not bone marrow dysfunction
What are the primary haematological disorders?
Haematological malignancies e.g. Leukaemia, primary haemostatic failure disorders (clotting/bleeding) and red cell disorders
What is cellular logistics?
Understanding at the genetic an protein level
