Bio Chapter 8- Mitosis and Cell Cycle Flashcards
Mitosis
Prophase, Prometaphase, Metaphase, Anaphase, Telophase
Chromosome number is conserved, 2 daughter cells made through asexual reproduction
Majority of Cell cycle
Interphase 90%. Growth and chromosomes are copied in prep for cell division.
M Phase
Includes mitosis and cytokinesis. Shortest of the cell cycle. All 5 stages (PPMAT).
Interphase
G1 first gap phase - cells begin to grow.
S phase - duplication of chromosomes
G2 second gap phase- cell prepares to divide
Growth is seen throughout all three phases- making organelles and proteins
Spindle apparatus
Move chromosomes. Composed of organized arrays of microtubules. Assembly of spindle microtubules start at the centrosome.
Centrosome
Two centrioles perpendicular to each other.
Just before mitosis, these two centrosomes move apart until the are opposite sides of the nucleus. As mitosis proceeds, microtubules grow out from each centrosome.
Do plant cells have centrioles?
No but they have mitotic spindles.
Prophase
Nucleoli disappear, chromosomes condense, centrioles move to opposite poles, mitotic spindle forms, chromatin fibers become coiled and chromosomes are observable under microscope.
Prometaphase
Chromosomes become more condensed. Nuclear envelope fragments and surrounds the nucleus. It has an inner and outer membrane. The nucleus protects the DNA and will help to contain repair enzymes and regulatory proteins.
Some microtubules attach to the kinetochores.
Kinetochore
a protein structure attached to the centromere that links the sister chromatids to the mitotic spindle. Kinetochore belongs to the chromosome.
Metaphase
Centrosomes are opposite ends. Sister chromatids of each chromosome are attached to the spindle. Chromosomes are lined up at the spindle equator.
Anaphase
Choesion proteins are cleaved, thus allowing the sister chromosomes to separate from each other and move to opposite poles.
End of anaphase, cytokinesis begins.
Telophase
2 daughter nuclei form, each with diploid 2n number. Cytokinesis occur. Chromosomes decondense and new nuclear membranes form.
Cleavage furrow
In animal cells, cytokinesis pinches the cell in two.
Cell plate
In plant cells, the cell plate will partition off the daughter cells.
Binary fission
Bacteria and Archaea reproduced.
G1 checkpoint
Most important, checkpoint for DNA damage. Also called restriction point. If G1 checkpoint is not passed, the cell switches to the nondividing state called G0.
Colchicine
Drug that destroys microtubules, thus stopping mitosis.
Somatic Cells
All body cells except reproductive cells (Haploid cells)
Aster
Array of microtubules that extend from each centrosome
Spindle
structure made of protein and microtubules. Spindle includes centrosomes, asters, and microtubules
Zygote
Fertilized egg cell (2N)
Tumor
clump of overlapping cells
Cell size is limited by two main factors
1) Nucleus capacity: Must have enough DNA
2) Surface area to volume ratio
Surface area and cell division
When the surface area gets too low, the cell cannot met its energy and metabolic requirements. The cell undergoes division.