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BB2 > BB2 Drugs > Flashcards

BB2 Drugs Flashcards

1
Q

Phenytoin

A

NA channel blocker
Stabilises inactivated state of channels; dose –dependent or zero order or saturation kinetics; liver enzyme induction; teratogenic effects; not used in absence seizures

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2
Q

Carbamazepine

A

NA channel blocker Stabilises the inactivated state of channels; liver enzyme induction; hypersensitivity reactions; not used in absence seizures

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3
Q

Sodium valproate

A

NA channel blocker
used in all
Not in pregnancy

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4
Q

Lamotrigine

A

Also activity at calcium channels; presynaptic inhibition of glutamate release – Favourable in pregnancy
Na channel blocker

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5
Q

Lacosamide

A

Binds to the inactivated state of channels

NA channel blocker

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6
Q

Zonisamide

A

Na + ca channel blocker

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7
Q

Ethosuximide

A

Calcium channel blocker

Used in absence seizures(Petit mal), blocks T-type calcium channels

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8
Q

Gabapentin (pregabalin)

A

Calcium channel blocker

Also increases GABA levels– Target the a2δ subunit

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9
Q

Benzodiazepines

A

Clonazepam
GABAA receptor positive allosteric modulators -
Sedation

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10
Q

Phenobarbitone

A

Barbiturate

GABAA receptor positive allosteric modulators

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11
Q

Levetiracetam

A

Neurotransmitter release

Binds to the synaptic protein SV2A; modulates neurotransmitter release

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12
Q

Tiagabine

A

Neurotransmitter uptake

Inhibits GAT-1 transporter for GABA

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13
Q

Vigabatrin

A

Neurotransmitter synthesis

Inhibition of GABA transaminase  protection of GABA

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14
Q

Topiramate

A

Na channel blocker

also active at AMPA and kainite glutamate receptors

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15
Q

Acetylcholinesterase inhibitors

A

Rivastigmine
Donzepezil
Galantamine
= Used in Alzheimers

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16
Q

NMDA receptor antagonist

A

Memantine (used in Alzheimers)

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17
Q

Acute Migraine treatment + MoA

A

Sumatriptan

5HT1D/B Agonist

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18
Q

Prophylactic Migraine treatment + MoA

A

Methysergide

5HT2B Antagonist

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19
Q

Amitriptyline

A

Tricyclic AD

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20
Q

MoA of tricyclic antidepressants + SE

A

Inhibit reuptake of amines (5HT and NA)
Also act on H1 receptors, muscarinic, A1 +2 adrenoreceptors
SE - blurred vision, urinary retention, dry mouth, weigh gain,arrhythmias
Cardiotoxicity in overdose

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21
Q

Noritryptyline

A

Tricyclic AD

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22
Q

Clomipramine

A

Tricyclic AD

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23
Q

Imipramine

A

Tricyclic AD

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24
Q

Desipramine

A

Tricyclic AD

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25
Q

Phenelzine

A

Monoamine Oxidase Inhibitors

TYRAMINE cheese effect

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26
Q

Tranylcycpromine

A

Monoamine Oxidase Inhibitors

Tyramine cheese effect

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27
Q

Iproniazid

A

Monoamine Oxidase Inhibitors

CHEESE EFFECT with tyramine

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28
Q

Citalopram

A

SSRI

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29
Q

Fluexitine

A

SSRI

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30
Q

Paraoxetine

A

SSRI

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31
Q

SE of SSRI

A

Nausea, Insomnia, Anxiety

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32
Q

Reversible monoamine oxidase inhibitor

A

Moclobemide

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33
Q

SNRI

A

Venlafaxine

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34
Q

NARI

A

Reboxetine

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35
Q

NaSSA

A

Mirtazapine

36
Q

SARI

A

Trazodone

37
Q

Levodopa

A

L-DOPA

38
Q

Carbidopa

A

DOPA decarboxylase inhibitor

39
Q

Benserazide

A

DOPA decarboxylase inhibitor

40
Q

Ropinirole

A

Dopamine agonist

41
Q

Pramipexole

A

Dopamine agonist

42
Q

Rotigotine

A

Dopamine agonist - Transdermal Patch

43
Q

Cabergoline

A

Dopamine agonist

44
Q

Bromocriptine

A

Dopamine agonist

45
Q

Apomorphine

A

Dopamine agonist -Transdermal patch

46
Q

Rasagiline

A

MAOB inhibitor

47
Q

Selegiline

A

MAOB inhibitor

48
Q

Orphenadrine

A

Anti-cholinergic

49
Q

Procyclidine

A

Anti-cholinergic

50
Q

Trihexyphenidyl

A

Anti-cholinergic

51
Q

Tolcapone

A

COMT inhibitor

52
Q

Entacapone

A

COMT inhibitor

53
Q

Tetrabenazine

A

Vesicular Amine Transport Inhibitor

54
Q

Lorazepam

A

ST benzo - Insomnia

55
Q

Temazepam

A

ST benzo Insomnia

56
Q

Eszopiclone

A

LT benzo - Insomnia

57
Q

Zolpidem

A

Z drugs - shorter half life so better for insomnia

58
Q

Suvorexant

A

Orexin antagonist

59
Q

Clonazepam

A

Benzodiazepine - anxiety

60
Q

Flumazenil

A

Give in overdose of clonazepam

61
Q

Alprazolam

A

Benzo - anxiety

62
Q

Buspirone

A

5HT1a agonist

63
Q

Ipsapirone

A

5HT1a agonist

64
Q

IFNb

A

Injectable MS drug

65
Q

GA

A

Injectable MS drug

66
Q

DMF

A

Oral MS drug

67
Q

Teriflunomid

A

Oral MS drug

68
Q

Natalizumab

A

MS drug

69
Q

Fingolimod

A

MS drug

70
Q

Alemtuzumab

A

MS drug

71
Q

Dilsulfiram

A

Antabuse

72
Q

Methadone

A

Drug substitute

73
Q

Clonidine

A

Withdrawal relief

74
Q

Nalrexone

A

Nicotine antagonist

75
Q

Varenicline

A

Partial nicotine agonist

76
Q

Chloropromazine

A

Typical antipsychotic

77
Q

Thiridazine

A

Typical antipsychotic

78
Q

Fluphenazine

A

Typical antipsychotic

79
Q

Fluphenthixol

A

Typical antipsychotic

80
Q

Haloperidol

A

Typical antipsychotic

81
Q

Risperidone

A

Atypical antipsychotic

82
Q

Olanzapine

A

Atypical antipsychotic

83
Q

Quetiapine

A

Atypical antipsychotic

84
Q

Clozapine

A

Atypical antipsychotic

85
Q

Aripiprazole

A

Atypical antipsychotic

86
Q

Paliperidone

A

Atypical antipsychotic

BB2 (27 decks)

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