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BB2 Drugs Flashcards

1
Q

Phenytoin

A

NA channel blocker
Stabilises inactivated state of channels; dose –dependent or zero order or saturation kinetics; liver enzyme induction; teratogenic effects; not used in absence seizures

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2
Q

Carbamazepine

A

NA channel blocker Stabilises the inactivated state of channels; liver enzyme induction; hypersensitivity reactions; not used in absence seizures

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3
Q

Sodium valproate

A

NA channel blocker
used in all
Not in pregnancy

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4
Q

Lamotrigine

A

Also activity at calcium channels; presynaptic inhibition of glutamate release – Favourable in pregnancy
Na channel blocker

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5
Q

Lacosamide

A

Binds to the inactivated state of channels

NA channel blocker

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6
Q

Zonisamide

A

Na + ca channel blocker

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7
Q

Ethosuximide

A

Calcium channel blocker

Used in absence seizures(Petit mal), blocks T-type calcium channels

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8
Q

Gabapentin (pregabalin)

A

Calcium channel blocker

Also increases GABA levels– Target the a2δ subunit

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9
Q

Benzodiazepines

A

Clonazepam
GABAA receptor positive allosteric modulators -
Sedation

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10
Q

Phenobarbitone

A

Barbiturate

GABAA receptor positive allosteric modulators

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11
Q

Levetiracetam

A

Neurotransmitter release

Binds to the synaptic protein SV2A; modulates neurotransmitter release

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12
Q

Tiagabine

A

Neurotransmitter uptake

Inhibits GAT-1 transporter for GABA

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13
Q

Vigabatrin

A

Neurotransmitter synthesis

Inhibition of GABA transaminase  protection of GABA

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14
Q

Topiramate

A

Na channel blocker

also active at AMPA and kainite glutamate receptors

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15
Q

Acetylcholinesterase inhibitors

A

Rivastigmine
Donzepezil
Galantamine
= Used in Alzheimers

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16
Q

NMDA receptor antagonist

A

Memantine (used in Alzheimers)

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17
Q

Acute Migraine treatment + MoA

A

Sumatriptan

5HT1D/B Agonist

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18
Q

Prophylactic Migraine treatment + MoA

A

Methysergide

5HT2B Antagonist

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19
Q

Amitriptyline

A

Tricyclic AD

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20
Q

MoA of tricyclic antidepressants + SE

A

Inhibit reuptake of amines (5HT and NA)
Also act on H1 receptors, muscarinic, A1 +2 adrenoreceptors
SE - blurred vision, urinary retention, dry mouth, weigh gain,arrhythmias
Cardiotoxicity in overdose

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21
Q

Noritryptyline

A

Tricyclic AD

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22
Q

Clomipramine

A

Tricyclic AD

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23
Q

Imipramine

A

Tricyclic AD

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24
Q

Desipramine

A

Tricyclic AD

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25
Phenelzine
Monoamine Oxidase Inhibitors | TYRAMINE cheese effect
26
Tranylcycpromine
Monoamine Oxidase Inhibitors | Tyramine cheese effect
27
Iproniazid
Monoamine Oxidase Inhibitors | CHEESE EFFECT with tyramine
28
Citalopram
SSRI
29
Fluexitine
SSRI
30
Paraoxetine
SSRI
31
SE of SSRI
Nausea, Insomnia, Anxiety
32
Reversible monoamine oxidase inhibitor
Moclobemide
33
SNRI
Venlafaxine
34
NARI
Reboxetine
35
NaSSA
Mirtazapine
36
SARI
Trazodone
37
Levodopa
L-DOPA
38
Carbidopa
DOPA decarboxylase inhibitor
39
Benserazide
DOPA decarboxylase inhibitor
40
Ropinirole
Dopamine agonist
41
Pramipexole
Dopamine agonist
42
Rotigotine
Dopamine agonist - Transdermal Patch
43
Cabergoline
Dopamine agonist
44
Bromocriptine
Dopamine agonist
45
Apomorphine
Dopamine agonist -Transdermal patch
46
Rasagiline
MAOB inhibitor
47
Selegiline
MAOB inhibitor
48
Orphenadrine
Anti-cholinergic
49
Procyclidine
Anti-cholinergic
50
Trihexyphenidyl
Anti-cholinergic
51
Tolcapone
COMT inhibitor
52
Entacapone
COMT inhibitor
53
Tetrabenazine
Vesicular Amine Transport Inhibitor
54
Lorazepam
ST benzo - Insomnia
55
Temazepam
ST benzo Insomnia
56
Eszopiclone
LT benzo - Insomnia
57
Zolpidem
Z drugs - shorter half life so better for insomnia
58
Suvorexant
Orexin antagonist
59
Clonazepam
Benzodiazepine - anxiety
60
Flumazenil
Give in overdose of clonazepam
61
Alprazolam
Benzo - anxiety
62
Buspirone
5HT1a agonist
63
Ipsapirone
5HT1a agonist
64
IFNb
Injectable MS drug
65
GA
Injectable MS drug
66
DMF
Oral MS drug
67
Teriflunomid
Oral MS drug
68
Natalizumab
MS drug
69
Fingolimod
MS drug
70
Alemtuzumab
MS drug
71
Dilsulfiram
Antabuse
72
Methadone
Drug substitute
73
Clonidine
Withdrawal relief
74
Nalrexone
Nicotine antagonist
75
Varenicline
Partial nicotine agonist
76
Chloropromazine
Typical antipsychotic
77
Thiridazine
Typical antipsychotic
78
Fluphenazine
Typical antipsychotic
79
Fluphenthixol
Typical antipsychotic
80
Haloperidol
Typical antipsychotic
81
Risperidone
Atypical antipsychotic
82
Olanzapine
Atypical antipsychotic
83
Quetiapine
Atypical antipsychotic
84
Clozapine
Atypical antipsychotic
85
Aripiprazole
Atypical antipsychotic
86
Paliperidone
Atypical antipsychotic

BB2 (27 decks)

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