AUTOPSY Flashcards
programmed cell death/cellular suicide
apoptosis
physiologic cell death
necrobiosis
pathologic cell death
necrosis
most common type of necrosis, tombstone formation
coagulation necrosis
organs in coagulation necrosis
MyLKS
- Myocardium
- Lungs
- Kidney
- Spleen
type of necrosis wherein there is pus formation on the brain and spinal cord
Liquefaction/Colliquative
type of necrosis wherein there is the presence of yellow, cheesy and crumbly material
Caseous/Caseation
caseous/caseation is present in
TB, syphilis, tularemia
type of necrosis wherein there is sulfide gas production
gangrenous necrosis
types of gangrenous necrosis
- gry gangrene
- wet gangrene
gangrene for arterial occlusion
dry gangrene
gangrene for venous occlusion
wet gangrene
types of necrosis for chalky white precipitate (pancreatic degeneration)
fat necrosis
types of necrosis for liver
fatty degeneration
death of entire organ system / individual
somatic death
post mortem cooling
Algor Mortis
temp of Algor mortis
70F grop of temp/hr
Stiffening (1st: neck and head, 2-3 hours) may persist for 3-4 days
Rigor mortis
Lividity and suggilation (purplish color)
livor mortis
drying and wrinkling of the anterior chamber of the eye
dessication
primary changes during somatic death
C- circular
R - respiratory
C - CNS failure
secondary changes after somatic death
A - Algor mortis
R - Rigor mortis
L - Livor mortis
D - Dessication
P - Putrefaction
A - Autolysis
Invasion of intestinal microorganisms
putrefaction
self-digestion of cells
autolysis
weight fo liver
1,100-1,600 g
weight of brain
1,150-1,450 g
weight of right lung
300-400 g
weight of left lung
250-350 g
weight of heart
250-300 g
weight of spleen
60-300 g
weight of thyroid
10-50 g
weight of adrenals
4g or so each
reports for autopsy
- surgical pathology report
- cytopathology report
- autopsy report
turnover of results for surgical pathology and cytopathology
24 hours
turnover of results for frozen section
5-15 minutes
turnover of results for autopsy report
1 week
how long is an autopsy procedure
24 hours
storage for specimen tissue
1 month to 1 year
storage for tissue blocks (paraffin)
3-10 years
storage for slides
indefinite
gold standard for confirmation of a medical disease
autopsy
types of autopsy
- complete autopsy
- partial autopsy
- selective autopsy
color of death certificate
blue
organs removed and dissected individually in the body and is widely used
Technique of virvhow
in-situ dissection in part combined with en bloc technique
- removing the body organs all at once
technique of rokitansky
en bloc technique
technique of ghon
en masse technique
technique of letulle
remain on original anatomic site
in-situ
dissection of whole cavity
en bloc
removal of entire regions and blocks and dissecting them
en masse
tumor marker for colon cancer
carcinoembryonic Ag (CEA)
better tumor marker
prostate specific Ag (PSA)
decipher PAP tumor marker
Prostatic acid phosphatase
seen in px with colorectal cancer
CA125
tumor marker for liver carcinoma, ovary and testicular carcinoma
alpha-fetoprotein (AFP)
hormone found in the placenta of pregnant women
hCG (Human chorionic gonadotrophin)
most commonly found enzyme
lactose dehydrogenase
found in neuroblastoma
NSE - Neuro specific enolase
found in px with breast CA
CA 15-3