autonomic nervous system and neurotransmitters Flashcards
what are the two divisions of the autonomic system?
parasympathetic and sympathetic divisions
what does the sympathetic system do?
prepares body for heightened activity, fight or flight
what does the parasympathetic system do?
stimulates abdominal visceral activity, conserves energy, rest and digest
how do somatic and autonomic nervous systems differ?
- neural (efferent) pathways
- effectors (target organs)
- organ response
- neurotransmitters
what is the control centre of the somatic nervous system?
primary motor cortex
what is the control centre of the autonomic nervous system?
hypothalamus
what are the central neurons of the somatic nervous system?
upper motor neurons
what are the central neurons of the autonomic nervous system?
CNS interneurons
what are the peripheral motor neurons of the somatic nervous system?
lower motor neurons
what are the peripheral motor neurons of the autonomic nervous system?
pre/post-ganglionic neurons
what are the targets of the somatic nervous system?
skeletal muscles
what are the targets of the autonomic nervous system?
- cardiac muscle
- smooth muscle
- glands
what is the function of the somatic nervous system?
voluntary movement, somatic reflexes
what is the function of the autonomic nervous system?
involuntary control of:
-visceral organ function
-glandular activity
visceral reflexes
what are the similarities of the sympathetic and parasympathetic systems?
- serve many of the same organs
- involve pre/post-ganglionic neurons
- pre-ganglionic neurons release ACh
- presence of ganglia
what are the differences of the sympathetic and parasympathetic systems?
- both divisions do not innervate all organs
- location of pre-ganglionic cell bodies and axon exit points from the CNS
- location of ganglia
what is the parasympathetic division also called?
craniosacral division
what is the sympathetic division also called?
thoracolumbar division
are the pre-ganglionic axons long or short in parasympathetic division?
long
are the post-ganglionic axons long or short in parasympathetic division?
short
are the pre-ganglionic axons long or short in sympathetic division?
short
are the post-ganglionic axons long or short in sympathetic division?
long
what are the cranial pathways of the parasympathetic division?
- CN III oculomotor nerve
- CN VII facial
- CN IX glossopharyngeal
- CN X vagus
is the ganglia in parasympathetic division close or far from the target organ?
close
is the ganglia in sympathetic division close or far from the target organ?
far
are sympathetic effects close or widespread?
widespread
what does the adrenal medulla in the sympathetic division release into the blood?
noradrenaline and adrenaline
what does noradrenaline and adrenaline released by the adrenal medulla do?
enhances and prolongs sympathetic effects
what neurotransmitter/s do pre-ganglionic neurons of the autonomic systems release?
ACh
what neurotransmitter/s do post-ganglionic neurons of the sympathetic division release?
noradrenaline
what neurotransmitter/s do post-ganglionic neurons of the parasympathetic division release?
ACh
what neurotransmitters do peripheral motor neurons use?
either acetylcholine or noradrenaline
what are receptors that bind acetylcholine called?
cholinergic receptors
what are receptors that bind noradrenaline (and adrenaline) called?
adrenergic receptors
what are the two types of cholinergic receptors?
nicotinic and muscarinic
what are the two types of adrenergic receptors?
alpha and beta
what is the effect of the neurotransmitter binding to a nicotinic receptor?
excitation, increased activity of target
what is the effect of the neurotransmitter binding to a muscarinic receptor?
- excitation of most targets
- inhibition of cardiac muscle, decreased activity
what is the location of muscarinic receptors?
all parasympathetic target organs
what is the location of nicotinic receptors?
- all ANS post-ganglionic neurons
- adrenal medullary cells
- skeletal muscles
are the two types of adrenergic receptors excitatory or inhibitory?
either excitatory or inhibitory
does an excitatory postsynaptic potential depolarise or hyperpolarise?
depolarise
does an inhibitory postsynaptic potential depolarise or hyperpolarise?
hyperpolarise
does an EPSP increase or decrease target activity?
increases
does an IPSP increase or decrease target activity?
decreases
what do agonists do to target neurotransmitter receptors?
drugs that mimic the action of the NT
what do antagonists do to target neurotransmitter receptors?
drugs that bind to the receptor and block the action of NT
what does noradrenaline stimulate?
reward and pleasure, reducing stress and enhancing attention
what does dopamine stimulate?
reward and pleasure
what are low levels of dopamine associated with?
depression
what does serotonin stimulate?
mood regulation, sleep, appetite, sexual desire and function
what are low levels of serotonin associated with?
depression
what does acetylcholine control?
motor control outside the CNS
what are biogenic amines associated with?
emotional behaviour
what is the main inhibitory NT in the brain?
GABA(y-aminobutyric acid)
what does GABA(y-aminobutyric acid) help regulate?
sleep/wakefulness
what is glutamate involved in?
learning and memory
why is substance P produced?
by damaged tissue
what does substance P stimulate and mediate?
peripheral nociceptors and mediates pain transmission to the CNS
what do endorphins inhibit?
perceptions of pain in the CNS