Autoantibodies Flashcards
In what disease would you get a positive anti-CCP antibody?
Rheumatoid arthritis
Why is anti-CCP better than RF in diagnosing RA?
More specific and a better predictor of disease course.
In what diseaseS would you get a positive anti- nuclear antibody?
SLE, Sjogrens, systemic sclerosis, Hep C, HIV,
In what disease would you get a positive anti-double stranded DNA antibody (dsDNA)?
SLE
In which disease is a positive anti-Sm(ith) found?
SLE
In which diseases in anti-Ro found?
SLE, Sjogrens syndrome
What is the potential risk with an anti-Ro?
Pregnancy
Where is an anti-La test found?
Sjogrens
Which disease has a positive anti-centromere?
Systemic sclerosis/CREST
Where are anti-cardiolipin antibodies and lupus anti-coagulants found?
Anti-phospholipid syndrome
Where is an anti- neutrophil cytoplasmic antibody (ANCA) positive test found?
Small vessel vasculitis
Polymyositis and dermatomyositis is often positive for what antibody?
Anti-Jo 1
What benefit can be seen by the measurement of anti-dsDNA for SLE?
High titres occur when disease is severe so allows monitoring.
