Antivirals: Acyclovir Flashcards

1
Q

What is the mechanism of action of acyclovir?

A
  • Substrate for viral thymidine kinase.
  • Converted to acyclovir monophosphate > acyclovir triphosphate > > incorporated into viral DNA chain resulting in chain termination
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the activity of action of acyclovir?

A

Herpes simplex virus (HSV) types 1 and 2

Varicella zoster virus (VZV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are examples of of action of acyclovir?

A

Acyclovir (IV/PO); valacyclovir (PO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the adverse effects of acyclovir?

A

Acute renal failure

Neurotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly