Antivirals: Acyclovir Flashcards
1
Q
What is the mechanism of action of acyclovir?
A
- Substrate for viral thymidine kinase.
- Converted to acyclovir monophosphate > acyclovir triphosphate > > incorporated into viral DNA chain resulting in chain termination
2
Q
What is the activity of action of acyclovir?
A
Herpes simplex virus (HSV) types 1 and 2
Varicella zoster virus (VZV)
3
Q
What are examples of of action of acyclovir?
A
Acyclovir (IV/PO); valacyclovir (PO)
4
Q
What is the adverse effects of acyclovir?
A
Acute renal failure
Neurotoxicity